磷酸化c-fos抗體，Anti-Phospho-c-Fos （Thr325）

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英文名稱 Anti-Phospho-c-Fos （Thr325）
中文名稱 磷酸化c-fos抗體
磷酸化c-fos抗體 別 名 c-Fos （phospho T325）; c-Fos （phospho-Thr325）; c-Fos （phospho Thr325）; p-c-Fos （Thr325）; Cellular oncogene fos; FBJ murine osteosarcoma viral v fos oncogene homolog antibody FBJ Osteosarcoma Virus; FOS; FOS protein; G0 G1 switch regulatory protein 7; G0S7; Oncogene FOS; Proto oncogene protein c fos; v fos FBJ murine osteosarcoma viral oncogene homolog; FOS; AP-1; C-FOS; p55; FOS_HUMAN; Proto-oncogene c-Fos; G0/G1 switch regulatory protein 7.
濃 度 1mg/1ml
規(guī) 格 0.1ml/100μg
抗體來源 Rabbit
克隆類型 polyclonal
交叉反應(yīng) Human, Mouse, Rat, Chicken, Dog, Pig, Sheep
產(chǎn)品類型 一抗 磷酸化抗體
研究領(lǐng)域 腫瘤 細胞生物 免疫學(xué) 神經(jīng)生物學(xué) 信號轉(zhuǎn)導(dǎo) 轉(zhuǎn)錄調(diào)節(jié)因子 腫瘤細胞生物標志物 表觀遺傳學(xué)
320841,5-O-二咖啡酰奎寧酸Cynarin30964-13-7 C25H24O12516.4520mg
320851,3-O-二咖啡?？鼘幩酑ynarin1182-34-9C25H24O12516.4520mg
32086綠原酸Chlorogenic acid327-97-9C16H18O9354.3120mg
32087新綠原酸Neochlorogenic acid906-33-2C16H18O9354.3087220mg
32088隱綠原酸Cryptochlorogenic acid905-99-7C16H18O9354.30920mg
32089異綠原酸AIsochlorogenic acid A2450-53-5C25H24O12516.45320mg
32090異綠原酸BIsochlorogenic acid B14534-61-3C25H24O12516.4520mg
32091異綠原酸CIsochlorogenic acid C32451-88-0C25H24O12516.45320mg
32092冬綠苷Gaultherin490-67-5C19H26O12 446.420mg
32093甜葉懸鉤子苷Rubusoside64849-39-4 C32H50O13642.7310mg
32094乙氧基白屈菜紅堿Ethoxychelerythrine152743-19-6C23H23NO5393.4310mg
32095紫萁酮Osmundacetone"C10H10O3
"17820mg
32096二氫姜黃素Dihydrocurcumin20mg
32097姜黃素Curcumin 458-37-7C21H20O6368.3820mg
32098去甲氧基姜黃素Demethoxycurcumin22608-11-3C20H18O5338.3520mg
32099雙去氧基姜黃素Bisdemethoxycurcumin24939-16-0C19H16O4308.3320mg
32100二苯乙烯苷2,3,5,4-tetrahydroxyl diphenylethylene-2-o-glucoside82373-94-2C20H22O9406.3920mg
321013,29-二苯甲酰基栝樓仁三醇3,29-Dibenzoyl rarounitriol873001-54-8C44H58O5666.93720mg
32102β，β’-二甲基丙烯酰阿卡寧β, β-dimethyl-acry-lalkannin34539-65-6C21H22O6370.420mg
32103紫草素Shikonin517-89-5C16H16O5288.320mg
32104紫草氰苷Lithosprmoside63492-69-3C14H19NO8329.1120mg
32105二氫辣椒素Dihydrocapsaicin19408-84-5C18H29NO3307.4320mg
32106辣椒素Capsaicin 2444-46-4C17H27NO3293.420mg
32107天然辣椒素Capsaicinoids404-86-420mg
32108槲皮素Quercetin 117-39-5C15H14O9338.2720mg
32109二氫槲皮素Taxifolin480-18-2C15H12O7304.2520mg
32110槲皮苷Quercitrin522-12-3C21H20O11448.3820mg
32111異槲皮苷Isoquercitrin"482-35-9
"C21H20O12464.3820mg
32112槲皮素-7-O-葡萄糖苷Quercetin-7-O-β-D-glucopyranoside491-50-9C21H20O12464.3810mg
32113槲皮素-3-O-β-D-葡糖糖-7-O-β-D-龍膽雙糖苷Quercetin-3-O-β-D-glucopyranosyl-7-O-β-D-gentiobiosid20mg
32114楊梅素Myricetin529-44-2C15H10O8318.2420mg
32115二氫楊梅素Dihydromyricetin27200-12-0C15H12O8320.2520mg
磷酸化c-fos抗體32116楊梅苷Myricitrin17912-87-7C21H20O12464.3820mg
蛋白分子量 predicted molecular weight: 41kDa
性 狀 Lyophilized or Liquid
免 疫 原 KLH conjugated Synthesised phosphopeptide derived from human c-Fos around the phosphorylation site of Thr325
亞 型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.01M PBS, pH 7.4 with 10 mg/ml BSA and 0.1% Sodium azide
產(chǎn)品應(yīng)用 WB=1:100-500 ELISA=1:500-1000 IP=1:20-100 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500
（石蠟切片需做抗原修復(fù)）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
Important Note This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
磷酸化c-fos抗體產(chǎn)品介紹 The Fos gene family consists of 4 members: FOS, FOSB, FOSL1, and FOSL2. These genes encode leucine zipper proteins that can dimerize with proteins of the JUN family, thereby forming the transcription factor complex AP-1. As such, the FOS proteins have been implicated as regulators of cell proliferation, differentiation, and transformation. In some cases, expression of the FOS gene has also been associated with apoptotic cell death. [provided by RefSeq, Jul 2008].
Function : Nuclear phosphoprotein which forms a tight butnon-covalently linked complex with the JUN/AP-1 transcriptionfactor. In the heterodimer, FOS and JUN/AP-1 basic regions eachseems to interact with symmetrical DNA half sites. On TGF-betaactivation, forms a multimeric SMAD3/SMAD4/JUN/FOS complex at theAP1/SMAD-binding site to regulate TGF-beta-mediated signaling. Hasa critical function in regulating the Has a critical function inregulating the development of cells destined to form and maintainthe skeleton. It is thought to have an important role in signaltransduction, cell proliferation and differentiation.
Subunit : Heterodimer; with JUN （By similarity）. Interacts withMAFB. Component of the SMAD3/SMAD4/JUN/FOS complexrequired for syngernistic TGF-beta-mediated transcription at theAP1 promoter site. Interacts with SMAD3; the interaction is weakeven on TGF-beta activation. Interacts with MAFB. Interacts withDSIPI; this interaction inhibits the binding of active AP1 to itstarget DNA.
Subcellular Location : Nucleus.
Post-translational modifications : Phosphorylated in the C-terminal upon stimulation by nerve growth factor （NGF） and epidermal growth factor （EGF）. Phosphorylated, in vitro, by MAPK and RSK1. Phosphorylation on both Ser-362 and Ser-374 by MAPK1/2 and RSK1/2 leads to protein stabilization with phosphorylation on Ser-374 being the major site for protein stabilization on NGF stimulation. Phosphorylation on Ser-362 and Ser-374 primes further phosphorylations on Thr-325 and Thr-331 through promoting docking of MAPK to the DEF domain. Phosphorylation on Thr-232, induced by HA-RAS, activates the transcriptional activity and antagonizes sumoylation. Phosphorylation on Ser-362 by RSK2 in osteoblasts contributes to osteoblast transformation.
Constitutively sumoylated by SUMO1, SUMO2 and SUMO3. Desumoylated by SENP2. Sumoylation requires heterodimerization with JUN and is enhanced by mitogen stimulation. Sumoylation inhibits the AP-1 transcriptional activity and is, itself, inhibited by Ras-activated phosphorylation on Thr-232.
Similarity : Belongs to the bZIP family. Fos subfamily.
Contains 1 bZIP domain
Database links : UniProtKB/Swiss-Prot: P01100.1