谷氨酰-脯氨酰-tRNA合成酶抗體

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英文名稱(chēng) Anti-Glutamyl Prolyl tRNA synthetase/ProRS
中文名稱(chēng) 谷氨酰-脯氨酰-tRNA合成酶抗體
 別 名 Bifunctional aminoacyl tRNA synthetase; Bifunctional aminoacyl-tRNA synthetase; Bifunctional glutamate/proline tRNA ligase; Cell proliferation-inducing gene 32 protein; DKFZp313B047; EARS; Eprs; GLNS; Glu pro tRNA synthetase; GLUPRORS; GluRS; Glutamate tRNA ligase; Glutamatyl prolyl tRNA synthetase; Glutaminyl tRNA synthetase; Glutamyl prolyl tRNA synthetase; Glutamyl tRNA synthetase; Glutamyl-tRNA synthetase; PARS; PIG 32; PIG32; Proliferation inducing gene 32 protein; Proliferation inducing protein 32; Proline tRNA ligase; Proline--tRNA ligase; Prolyl tRNA synthetase; Prolyl-tRNA synthetase; QARS; QPRS; SYEP_HUMAN.
濃 度 1mg/1ml
規(guī) 格 0.2ml/200μg
抗體來(lái)源 Rabbit
克隆類(lèi)型 polyclonal
交叉反應(yīng) Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, Sheep
產(chǎn)品類(lèi)型 一抗
研究領(lǐng)域 細(xì)胞生物 信號(hào)轉(zhuǎn)導(dǎo) 轉(zhuǎn)運(yùn)蛋白 表觀遺傳學(xué)
46733phospho-FAK（pTyr577） 磷酸化粘著斑激酶抗原 0.5mg
46734phospho-FAK（pSer732）（phospho-Focal adhesion kinase） 磷酸化粘著斑激酶抗原 0.5mg
46735FAST kinase（Fas-activated serine/threonine kinase） Fas活化的絲/蘇氨酸激酶抗原 0.5mg
46736FBN1 （fibrillin 1） 原纖維蛋白1抗原 0.5mg
46737FGF4/HSTF1/HBGF-4（Fibroblast Growth Factor4） 纖維母細(xì)胞生長(zhǎng)因子4抗原 0.5mg
46738FGF5 peptide 纖維母細(xì)胞生長(zhǎng)因子5抗原 0.5mg
46739Fibulin 1 衰老關(guān)鍵蛋白抗原 0.5mg
46740FLG（filaggrin）peptide 絲聚蛋白/中間絲蛋白抗原 0.5mg
46741FOS B FosB抗原 0.5mg
46742FRA2/FOSL2（Fos related/like antigen 2） FOS樣抗原2 0.5mg
46743FOXF1（Forkhead box protein F1） 叉頭蛋白F1抗原 0.5mg
46744FOXJ1/HFH-4 peptide 插頭蛋白J1抗原 0.5mg
46745FoxP1（Forkhead box P1） FoxP1（T細(xì)胞轉(zhuǎn)錄因子）抗原 0.5mg
46746FOXM1/HFH 11 peptide 插頭蛋白M1抗原 0.5mg
46747Measles virus of fusion protein 麻疹病毒抗原（麻疹病毒融合蛋白） 0.5mg
蛋白分子量 predicted molecular weight: 171kDa
性 狀 Lyophilized or Liquid
免 疫 原 KLH conjugated synthetic peptide derived from human Glutamyl Prolyl tRNA synthetase/ProRS
亞 型 IgG
純化方法 affinity purified by Protein A
儲(chǔ) 存 液 Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4
產(chǎn)品應(yīng)用 WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500
（石蠟切片需做抗原修復(fù)）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
Important Note This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
產(chǎn)品介紹 The fidelity of protein synthesis requires efficient discrimination of amino acid substrates by aminoacyl-tRNA synthetases. Aminoacyl-tRNA synthetases function to catalyze the aminoacylation of tRNAs by their corresponding amino acids, thus linking amino acids with tRNA-contained nucleotide triplets. ProRS （Prolyl-tRNA synthetase）, also known as EPRS, EARS, PARS, QARS, QPRS, PIG32 or GLUPRORS, is a 1,512 amino acid protein that contains three WHEP-TRS domains and belongs to both the class-I and class-II aminoacyl-tRNA synthetase family. Functioning as a component of the multisynthase complex, ProRS uses ATP to catalyze the conversion of L-glutamate and tRNA（Glu） to L-glutamyl-tRNA（Glu）, as well as the conversion of L-proline and tRNA（Pro） to L-prolyl-tRNA（Pro）.
Function : Catalyzes the attachment of the cognate amino acid to the corresponding tRNA in a two-step reaction: the amino acid is first activated by ATP to form a covalent intermediate with AMP and is then transferred to the acceptor end of the cognate tRNA.
Subunit : Component of the multisynthetase complex which iscomprised of a bifunctional glutamyl-prolyl-tRNA synthetase, themonospecific isoleucyl, leucyl, glutaminyl, methionyl, lysyl,arginyl, and aspartyl-tRNA synthetases as well as three auxiliaryproteins, p18, p48 and p43. Interacts with DUS2L. Component of theGAIT complex; in humans the complex assembly seems to be a two-stepprocess in which EPRS first associates with SYNCRIP to form apre-GAIT complex which is deficient in GAIT element binding.
Post-translational modifications : Phosphorylated at Ser-886 by CDK5 in a IFN-gamma-dependent manner; this phosphorylation activates assembly of the GAIT （IFN-gamma-activated inhibitor of translation） complex, which suppresses expression of a post-transcriptional regulon of proinflammatory genes in myeloid cells.
Similarity : In the N-terminal section; belongs to the class-I aminoacyl-tRNA synthetase family.
In the C-terminal section; belongs to the class-II aminoacyl-tRNA synthetase family.
Contains 3 WHEP-TRS domains.
Database links : UniProtKB/Swiss-Prot: P07814.5