ProOx-811 模擬高海拔實驗環(huán)境動物實驗低壓氧艙

模擬高海拔實驗環(huán)境動物實驗低壓氧艙人性化操作產(chǎn)品特點：

1、采用10英寸觸摸屏，人性化界面設計，操作簡便。

2、兩種控制方式：自動、手動，斷電可操控；具有傳感器組件及機械表雙重監(jiān)測功能。設備自動化程序設計，無須專人守候，可長期持續(xù)運轉(zhuǎn)。

3、實時顯示海拔和氧分壓動態(tài)變化曲線。

4、實驗過程數(shù)據(jù)可導出csv格式保存到U盤中，在電腦中讀取分析。

5、可根據(jù)客戶實驗需求，訂制實驗環(huán)境及配套其他相關(guān)實驗設備。

6、配備動物低壓專用水瓶，防止在負壓環(huán)境中，水滴漏速過快。

操作安全放心：

1、配備自動換氣功能，符合動物飼養(yǎng)規(guī)范。

2、提供多方位報警功能（溫度、濕度、壓力、氧濃度 上/下限），防止出現(xiàn)安全隱患。配備漸開手輪式艙門，降低因為誤操作造成的傷害。

3、艙體采用透明厚亞克力材質(zhì)，方便研究人員觀察實驗動物情況。

4、配備氣體緩沖器，減小、甚至消除了細股急流氣體對小動物的影響。

5、配備多級空氣過濾器，確保動物艙內(nèi)實驗環(huán)境空氣不會收到污染。

6、艙體模擬承受力分析，確保這種結(jié)構(gòu)足夠安全。

模擬高海拔實驗環(huán)境動物實驗低壓氧艙參數(shù)顯示/功能全：

拓展及特殊定制：

動物生理指標監(jiān)測；

可實現(xiàn)的監(jiān)測指標：心電圖、心率、體溫、血壓、呼吸、血氧飽和度；

呼吸代謝監(jiān)控功能；

采血給藥功能；

視頻監(jiān)測功能；

動物低氧跑臺裝置；

低氧強迫游泳裝置；

溫控功能；

恒溫功能，溫度可控制，室溫-40℃；

低溫功能，4℃，溫度可控制，室溫-4℃；

可定制其它功能；

應用領(lǐng)域：

高原醫(yī)學研究、肺水腫、腦水腫、肺動脈高壓等疾病研究；

型號說明：

使用客戶名單：

相關(guān)文獻：

[1]Ma Jinqiu,Wang Chenyun,Sun Yunbo,Pang Lulu,Zhu Siqing,Liu Yijing,Zhu Lin,Zhang Shouguo,Wang Lin,Du Lina. "Comparative study of oral and intranasal puerarin for prevention of brain injury induced by acute high-altitude hypoxia" . [J] International Journal of Pharmaceutics,2020,591.

?[2]Guijuan Chen,Kang Cheng,Yun Niu,Li Zhu,Xueting Wang."Epicatechin gallate prevents inflammatory response in hypoxia-activated microglia and cerebral edema by inhibiting NF-κB signaling" . [J]. Archives of Biochemistry and Biophysics ,Volume 729, 109393.

[3]Yapeng,LuPanpanChang,WangwangDing,JiangpeiBian,DanWang,XuetingWang,QianqianLuo,XiaomeiWu,LiZhu."Pharmacological inhibition of mitochondrial division attenuates simulated high-altitude exposure-induced cerebral edema in mice: Involvement of inhibition of the NF-κB signaling pathway in glial cells". [J]. European Journal of Pharmacology,Volume 929,2022,175137.

[4]Jun-Yu Wei, Miao-Yue Hu, Xiu-Qi Chen, Feng-Ying Lei, Jin-Shuang Wei, Jie Chen, Xuan-Kai Qin & Yuan-Han Qin ."Rosiglitazone attenuates hypoxia-induced renal cell apoptosis by inhibiting NF-κB signaling pathway in a PPARγ-dependent manner" . [J]. European Journal of Pharmacology,Renal Failure, 44:1, 2056-2065.

[5]Yilan Wang, Zherui Shen, Caixia Pei, Sijing Zhao, Nan Jia, Demei Huang, Xiaomin Wang, Yongcan Wu, Shihua Shi, Yacong He, Zhenxing Wang,"Eleutheroside B ameliorated high altitude pulmonary edema by attenuating ferroptosis and necroptosis through Nrf2-antioxidant response signaling" . [J]. Biomedicine & Pharmacotherapy, Volume 156, 2022,113982.

[6]Fang Zhao, Yan Meng, Yue Wang, Siqi Fan, Yu Liu,Xiangfeng Zhang, Chenyang Ran, Hongxin Wang and Meili Lu. "Protective effect of Astragaloside IV on chronic intermittent hypoxia-induced vascular endothelial dysfunction through the calpain-1/SIRT1/AMPK signaling pathway" .[J]. Frontiers in Pharmacology,10.3389/fphar.2022.920977.

[7]Xu Y, Kong X, Li J, Cui T, Wei Y, Xu J, Zhu Y , Zhu X. “Mild Hypoxia Enhances the Expression of HIF and VEGF and Triggers the Response to Injury in Rat Kidneys.” [J]. Front. Physiol. 12:690496. doi: 10.3389/fphys.2021.690496

[8]Liang Xie, Qinhan Wu, Weiping Hu, Xu Wu, Guiling Xiang, Shengyu Hao, Han Guo, Shanqun Li. “Impact of histaminergic H3 receptor antagonist on hypoglossal nucleus in chronic intermittent hypoxia conditions.” [J]. Psychopharmacology. 

[9]Li Huang, Tianyou Li, Min Zhou, Mengyan Deng, Lidong Zhang, Long Yi, Jundong Zhu, Xiaohui Zhu, Mantian Mi. “Hypoxia Improves Endurance Performance by Enhancing Short Chain Fatty Acids Production via Gut Microbiota Remodeling.” [J]. Front. Microbiol. 12:820691

[10]Yanhong Pei a b, Lifei Huang c, Tong Wang c, Qinhan Yao a, Yanrong Sun a, Yan Zhang a, Xiaomei Yang a, Jiliang Zhai d, Lihua Qin a, Jiajia Xue c, Xing Wang c, Hongquan Zhang a b, Junhao Yan."Bone marrow mesenchymal stem cells loaded into hydrogel/nanofiber composite scaffolds ameliorate ischemic brain injury. materialstoday ADVANCES, Volume 17, March 2023, 100349.

[11]Zhang, C., Sun, Y., Guo, Y. et al. “JMJD1C promotes smooth muscle cell proliferation by activating glycolysis in pulmonary arterial hypertension. “[J].Cell Death Discov. 9, 98 (2023).

[12]Chenyu Xu, Jun Xu, Chunfang Zou, Qian Li, Shan Mao, Ying Shi, Yan Tan, Wei Gu, Liang Ye. "Chronic Intermittent Hypoxia Regulates CaMKII-Dependent MAPK Signaling to Promote the Initiation of Abdominal Aortic Aneurysm."  [J]. Hindawi, Oxidative Medicine and Cellular Longevity Volume 2021, Article ID 2502324, 15 pages

[13]Jing Zhang, Jian-Zhong Jiang, Jun Xu, Chen-Yu Xu, Shan Mao, Ying Shi, Wei Gu, Chun-Fang Zou, Yue-Ming Zhao,  Liang Ye. "Identification of Novel Biomarkers for Abdominal Aortic Aneurysm Promoted by Obstructive Sleep Apnea." [J].  Elsevier Inc. This is an open access article under the CC BY-NC-ND license

[14]Zhang Q, Xu L, Bai Y, Chen P, Xing M, Cai F, Wu Y,  Song W. “Intermittent hypoxia-induced enhancement of sociability and working memory associates with CNTNAP2 upregulation.” [J]. Front. Mol. Neurosci. 16:1155047.

[15]Chen Zhang, Yue Sun, Yingying Guo, Jingjing Xu, Haiyan Zhao. “JMJD1C promotes smooth muscle cell proliferation by activating glycolysis in pulmonary arterial hypertension.” [J]. Cell Death Discovery (2023) 9:98.

MFN2-mediated mitochondrial fusion facilitates acute hypobaric hypoxia-induced cardiac dysfunction by increasing glucose catabolism and ROS production,Biochimica et Biophysica Acta (BBA) - General Subjects,Volume 1867, Issue 9,2023,130413,ISSN 0304-4165

[17]Eleutheroside E from pre-treatment of Acanthopanax senticosus (Rupr. etMaxim.) Harms ameliorates high-altitude-induced heart injury by regulating NLRP3 …N Jia, Z Shen, S Zhao, Y Wang, C Pei, D Huang… - International …, 2023 - Elsevier… The rats were placed in a hypobaric hypoxia chamber (ProOx-830, Tow-Int Tech, Shanghai,China) to mimic the environment of high-altitude hypobaric hypoxic. After the rats were …

[18]Nan Jia, Zherui Shen, Sijing Zhao, Yilan Wang, Caixia Pei, Demei Huang, Xiaomin Wang, Yongcan Wu, Shihua Shi, Yacong He, Zhenxing Wang,Eleutheroside E from pre-treatment of Acanthopanax senticosus (Rupr.etMaxim.) Harms ameliorates high-altitude-induced heart injury by regulating NLRP3 inflammasome-mediated pyroptosis via NLRP3/caspase-1 pathway,International Immunopharmacology,Volume 121,2023,110423,ISSN 1567-5769

[19]AUTHOR=Long Yanrong, Chen Hongbin, Deng Junchao, Ning Junjie, Yang Pengbo, Qiao Lina, Cao Zhongwei ，TITLE=Deficiency of endothelial FGFR1 alleviates hyperoxia-induced bronchopulmonary dysplasia in neonatal mice ，JOURNAL=Frontiers in Pharmacology VOLUME=13 YEAR=2022  DOI=10.3389/fphar.2022.1039103 ，The chamber contained a continuous oxygen monitoring system (ProOX-100HE, TOW-INTTECH) 

參考：

高原疾病介紹;

不同的海拔高度大氣壓和氧分壓的變化對比;

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