78611 Anti-CD20 CAR-T Cells
- 公司名稱 BPS Bioscience Inc.
- 品牌 BPS Bioscience
- 型號 78611
- 產地
- 廠商性質 生產廠家
- 更新時間 2024/11/26 17:40:13
- 訪問次數(shù) 224
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BPS Bioscience專注于開發(fā)高質量的產品，提供優(yōu)質的客戶服務，并維護穩(wěn)健的質量管理體系。BPS Bioscience現(xiàn)已通過ISO 9001:2015認證，確保質量的持續(xù)監(jiān)控和持續(xù)改進，從而滿足客戶需求。
BPS Bioscience產品涉及臨床前藥物開發(fā)過程的每個階段。其中部分產品可以用于許多研究階段。BPS Bioscience將繼續(xù)豐富我們的產品線，希望以此推動了整個早期藥物研發(fā)過程。
生物試劑
The anti-CD20 CAR-T cells are produced by high-titer lentiviral transduction of human primary CD4+CD8+ T cells using the anti-CD20 CAR Lentivirus (CD20 ScFv-CD8-4-1BB-CD3ζ; BPS Bioscience #78606). These ready-to use CAR-T cells express an anti-CD20 CAR consisting of the ScFv (Single chain fragment variable) of anti-CD20 (clone Leu-16) linked to a 2nd generation CAR (Chimeric Antigen Receptor) containing CD8 hinge and transmembrane domains, and the 4-1BB and CD3ζ signaling domains (Figure 1).
These CAR-T cells have been validated using flow cytometry (to determine the CAR expression) and co-culture cytotoxicity assays.
Figure 1: Construct diagram showing components of the anti-CD20 CAR expressed in anti-CD20 CAR-T cells.
相關分類
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