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jena bioscience抗病毒核苷/核苷酸類似物
2020-3-4 閱讀(865)
西美杰代理jena bioscience抗病毒核苷/核苷酸類似物--助力新型冠狀病毒相關(guān)藥物研發(fā)
持續(xù)近兩個(gè)多月的新型冠狀病毒感染的肺炎疫情牽動(dòng)著每一個(gè)人的心，為了打贏這場(chǎng)疫情防控狙戰(zhàn)，搞清致病機(jī)理，研發(fā)抗病毒相關(guān)藥物和疫苗刻不容緩。Jena bioscience品牌有豐富的抗病毒核苷酸/核苷酸類似物，助力抗病毒的藥物研發(fā)。
抗病毒核苷及核苷酸類似物主要有:
抗病毒核苷/核苷酸類似物可以通過(guò)抑制病毒復(fù)制的幾個(gè)關(guān)鍵過(guò)程來(lái)抑制病毒繁殖，它們通過(guò)與天然的dNTP/NTP競(jìng)爭(zhēng)結(jié)合到新的病毒核酸中，從而導(dǎo)致鏈終止或者誘變。在細(xì)胞培養(yǎng)實(shí)驗(yàn)中，可以用抗病毒核苷酸的非磷酸化核苷變體，這種核苷酸在細(xì)胞內(nèi)被多種病毒和/或宿主激酶激活，從而發(fā)揮(tri)磷酸化形式的抗病毒作用。
西美杰代理jena bioscience抗病毒核苷/核苷酸類似物--助力新型冠狀病毒相關(guān)藥物研發(fā)
熱銷抗病毒核苷/核苷酸類似物：
貨號(hào) | 品名 | 規(guī)格 |
NU-1605S | 3TCMP | 10 μl (10 mM) |
NU-1605L | 3TCMP | 5 x 10 μl (10 mM) |
NU-1606S | 3TCTP | 5 μl (10 mM) |
NU-1606L | 3TCTP | 5 x 5 μl (10 mM) |
NU-1603S | d4TMP | 20 μl (10 mM) |
NU-1603L | d4TMP | 5 x 20 μl (10 mM) |
NU-1601S | AzTMP | 20 μl (10 mM) |
NU-1601L | AzTMP | 5 x 20 μl (10 mM) |
NU-989S | AzTTP | 10 μl (100 mM) |
NU-989L | AzTTP | 5 x 10 μl (100 mM) |
NU-875 | ara-Adenosine-5'-monophosphate (ara-AMP) | 2 mg |
NU-1111S | 50 μl (10 mM) | |
NU-1111L | ara-Adenosine-5'-triphosphate (ara-ATP) | 5 x 50 μl (10 mM) |
NU-876 | Acyclovir-5'-monophosphate | 2 mg |
NU-877 | Acyclovir-5'-triphosphate | 2 mg |
NU-021-2 | Ribavirin-5'-monophosphate | 2 mg |
NU-1105S | 20 μl (10 mM) | |
NU-1105L | Ribavirin-triphosphate | 5 x 20 μl (10 mM) |
N-DN-8234-100 | β-L-2'-Deoxythymidine | 100 mg |
NU-896S | 10 μl (100 mM) | |
NU-896L | 6-Aza-UTP | 5 x 10 μl (100 mM) |
NU-974 | Tenofovir | 100 mg |
NU-975 | Tenofovir-diphosphate | 1 mg |
NU-989S | 10 μl (100 mM) | |
NU-989L | AzTTP | 5 x 10 μl (100 mM) |
NU-275S | 10 μl | |
NU-275L | Ganciclovir-triphosphate | 5 x 10 μl |
西美杰是Jena bioscience中國(guó)總代理\德國(guó)耶拿總代理，為用戶提供完善的技術(shù)與售后服務(wù)。西美杰會(huì)更好的協(xié)助科研工作者的實(shí)驗(yàn)工作，支持全國(guó)戰(zhàn)“疫”，早日戰(zhàn)勝病毒。武漢加油！中國(guó)加油！
參考文獻(xiàn)：
1] Huang at al. (2011) Effect of reverse transcriptase inhibitors on Line-1 and Ty1 reverse transcriptase activities and on LINE-1 retrotransposition. BMC Biochemistry 12:18.
[2] Vaccaro at al. (1999) Mechanism of Inhibition of the Human Immunodeficiency Virus Type 1 Reverse Transcriptase by d4TTP: an Equivalent Incorporation Efficiency Relative to the Natural Substrate dTTP. Antimicrob. Agents Chemother. 44 (1):217.
[3] Jaju at al. (1995) Human immunodeficiency virus type 1 reverse transcriptase. 3'-Azidodeoxythymidine 5'-triphosphate inhibition indicates two-step binding for template-primer. J. Biol. Chem. 270 (17):9740.
[4] Furmann at al. (1979) Inhibition of Herpes Simplex Virus-Induced DNA Polymerase Activity and Viral DNA Replication by 9-(2-Hydroxyethoxymethyl)guanine and Its Triphosphate. J. Virol. 29 (2):154.
[5] Muller at al. (1977) Inhibition of Herpesvirus DNA synthesis by 9-O-D-Arabinofuranosyladenine in cellular and cell-free systems. Ann. N.Y. Acad. Sci. 284:34.
[6] Crotty at al. (2000) The broad-spectrum antiviral ribonucleoside ribavirin is an RNA virus mutagen. Nature Medicine 6 (12):1375.
[7] Ray at al. (2009) Metabolism of antiviral nucleosides and nucleotides. In: Antiviral Research: Strategies in antiviral drug discovery (LaFemina). ASM Press.
[8] Simons at al. (2005) Recent Advances in Antiviral Nucleoside and Nucleotide Therapeutics. Current Topics in Medicinal Chemistry 5:1191.
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