NLG-919 1402836-58-1 返回列表頁

NLG-919  1402836-58-1

NLG-919
分子式：C18H22N2O   分子量：282.38
 
產(chǎn)品描述
NLG919是新型有效的indoleamine-2,3-dioxygenase (IDO)抑制劑，EC50為75 nM。
靶點(diǎn)
IDO
IDO
       
IC50
7 nM (Ki)
75 nM (EC50)
       
體外研究
NLG919 potently blocks IDO-induced T-cell suppression and restored robust T-cell responses with ED50 of 80 nM. Similarly, using IDO-expressing mouse DCs from tumor-draining lymph nodes, NLG919 abrogated IDO-induced suppression of antigen-specific T cells (OT-I) in vitro, with ED50 of 120 nM.
體內(nèi)研究
In mice, a single oral administration of NLG919 reduces the concentration of plasma and tissue Kyn by ~ 50%. In mice bearing B16F10 tumors, NLG919 markedly enhances the antitumor responses of naive, resting pmel-1 cells to vaccination with cognate hgp100 peptide plus CpG-1826 in IFA.
溶解性
DMSO 56 mg/mL，水 <1 mg/mL，乙醇 56 mg/mL
穩(wěn)定性
2年 -20°C粉狀，6月-80°C溶于DMSO