目錄:北京索萊寶科技有限公司>>抗體>>Polyclonal Antibody>> K101310PAnti-PCNA Polyclonal Antibody
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供貨周期:現(xiàn)貨 規(guī)格:50ul/100ul 貨號:K101310P 應(yīng)用領(lǐng)域:醫(yī)療衛(wèi)生,環(huán)保,化工,生物產(chǎn)業(yè),農(nóng)業(yè) 主要用途:WB
>更新時間:2022-08-15 09:06:40瀏覽次數(shù):743評價
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供貨周期 | 現(xiàn)貨 | 規(guī)格 | 50ul/100ul |
---|---|---|---|
貨號 | K101310P | 應(yīng)用領(lǐng)域 | 醫(yī)療衛(wèi)生,環(huán)保,化工,生物產(chǎn)業(yè),農(nóng)業(yè) |
主要用途 | WB |
Anti-PCNA Polyclonal Antibody
英文名稱 | Anti-PCNA Polyclonal Antibody |
---|---|
宿主 | Rabbit |
別名 | ATLD2;cb16;Cyclin;HGCN872;MGC8367 |
應(yīng)用 | WB |
稀釋比例 | WB 1:500-2000. |
交叉反應(yīng) | Human Mouse Rat |
蛋白分子量 | 29kDa |
Gene ID | 5111 |
保存 | Store at -20°C. Avoid freeze / thaw cycles. |
儲存液 | Buffer: PBS with 0.03% Proclin300, 50% glycerol, pH7.3. |
純化方法 | Affinity purification |
亞型 | IgG |
免疫原 | A synthetic peptide of human PCNA |
性狀 | 液體 |
Public Immunogen Range | A synthetic peptide of human PCNA |
Subcellular Locations | Nucleus |
Swiss Prot | P12004 |
克隆類型 | Polyclonal Antibody |
背景資料 | Auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand. Induces a robust stimulatory effect on the 3'-5' exonuclease and 3'-phosphodiesterase, but not apurinic-apyrimidinic (AP) endonuclease, APEX2 activities. Has to be loaded onto DNA in order to be able to stimulate APEX2. Plays a key role in DNA damage response (DDR) by being conveniently positioned at the replication fork to coordinate DNA replication with DNA repair and DNA damage tolerance pathways. Acts as a loading platform to recruit DDR proteins that allow completion of DNA replication after DNA damage and promote postreplication repair: Monoubiquitinated PCNA leads to recruitment of translesion (TLS) polymerases, while 'Lys-63'-linked polyubiquitination of PCNA is involved in error-free pathway and employs recombination mechanisms to synthesize across the lesion. |