目錄:北京索萊寶科技有限公司>>抗體>>Polyclonal Antibody>> K107442PAnti-MYH11 Polyclonal Antibody
供貨周期 | 現(xiàn)貨 | 規(guī)格 | 50ul/100ul |
---|---|---|---|
貨號 | K107442P | 應(yīng)用領(lǐng)域 | 醫(yī)療衛(wèi)生,環(huán)保,化工,生物產(chǎn)業(yè),農(nóng)業(yè) |
主要用途 | WB |
Anti-MYH11 Polyclonal Antibody
宿主 | Rabbit |
---|---|
英文名稱 | Anti-MYH11 Polyclonal Antibody |
別名 | AAT4;FAA4;SMHC;SMMHC;myosin-11 |
應(yīng)用 | WB |
稀釋比例 | WB 1:5000-8000. |
蛋白分子量 | 223-228kDa |
保存 | Store at -20°C. Avoid freeze / thaw cycles. |
儲存液 | Buffer: PBS with 0.03% Proclin300, 50% glycerol, pH7.3. |
純化方法 | Affinity purification |
亞型 | IgG |
免疫原 | A synthetic peptide of human MYH11 |
Subcellular Locations | Cytoplasm |
Swiss Prot | P35749 |
克隆類型 | Polyclonal Antibody |
背景資料 | The protein encoded by this gene is a smooth muscle myosin belonging to the myosin heavy chain family. The gene product is a subunit of a hexameric protein that consists of two heavy chain subunits and two pairs of non-identical light chain subunits. It functions as a major contractile protein, converting chemical energy into mechanical energy through the hydrolysis of ATP. The gene encoding a human ortholog of rat NUDE1 is transcribed from the reverse strand of this gene, and its 3' end overlaps with that of the latter. The pericentric inversion of chromosome 16 [inv(16)(p13q22)] produces a chimeric transcript that encodes a protein consisting of the first 165 residues from the N terminus of core-binding factor beta in a fusion with the C-terminal portion of the smooth muscle myosin heavy chain. This chromosomal rearrangement is associated with acute myeloid leukemia of the M4Eo subtype. Alternative splicing generates isoforms that are differentially expressed, with ratios changing during muscle cell maturation. Alternatively spliced transcript variants encoding different isoforms have been identified. |
多克隆抗體
由于多克隆抗體通常包含抗某一抗原的不同表位的抗體,所以,在深固定的樣本中也會很好地發(fā)揮效應(yīng),在石蠟包埋組織切片的染色中,多克隆抗體常選用。根據(jù)實(shí)驗(yàn)的不同需要,多克隆抗體應(yīng)用于相應(yīng)抗原的標(biāo)記。此外,在農(nóng)業(yè)生產(chǎn)中,多克隆抗體被用于農(nóng)藥殘留現(xiàn)場監(jiān)測;在臨床應(yīng)用中,多克隆抗體主要用于病原物的檢測、疾病的診斷及治療,如作為蛋白類免疫抑制劑用于移植反應(yīng)和自身免疫病的治療。
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