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上海源葉生物科技有限公司
主營(yíng)產(chǎn)品: S30260異硫氰酸胍,30259鹽酸胍,嗜熱菌蛋白酶 |
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15
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15921386130
公司信息
- 聯(lián)系人:
- 何小姐
- 電話:
- 86-021-61559134
- 手機(jī):
- 15921386130
- 傳真:
- 86-021-55068248
- 地址:
- 上海市松江區(qū)長(zhǎng)塔路465號(hào)6幢
- 郵編:
- 200433
- 網(wǎng)址:
- www.shyuanye.com
S80075
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更新時(shí)間:2024-07-03 20:23:53瀏覽次數(shù):92
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- 產(chǎn)品描述: CP-466722 is a rapidly reversible inhibitor of ATM, with an IC50 of 4.1 μM, and has no effects on PI3K or closely related PI3K-like protein kinase (PIKK) family members.
- 靶點(diǎn): ATM:4.1 μM (IC50)
- 參考文獻(xiàn):
1. Rainey MD, et al. Transient inhibition of ATM kinase is sufficient to enhance cellular sensitivity to ionizing radiation. Cancer Res. 2008 Sep 15;68(18):7466-74. 2. Guo K, et al. Development of a cell-based, high-throughput screening assay for ATM kinase inhibitors. J Biomol Screen. 2014 Apr;19(4):538-46. 3. W?sierska-G?dek J, et al. Interactions Between Ataxia Telangiectasia Mutated Kinase Inhibition, Poly(ADP-ribose) Polymerase-1 Inhibition and BRCA1 Status in Breast Cancer Cells. J Cancer Prev. 2014 Jun;19(2):125-36.
- 溶解度: DMSO : 1 mg/mL (2.86 mM; Need ultrasonic)
- 保存條件: 2-8℃
- 配置溶液濃度參考:
1mg 5mg 10mg 1 mM 2.862 ml 14.312 ml 28.625 ml 5 mM 0.572 ml 2.862 ml 5.725 ml 10 mM 0.286 ml 1.431 ml 2.862 ml 50 mM 0.057 ml 0.286 ml 0.572 ml
- 注意:部分產(chǎn)品我司僅能提供部分信息,我司不保證所提供信息的性,僅供客戶參考交流研究之用。