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上海源葉生物科技有限公司
主營產(chǎn)品： S30260異硫氰酸胍,30259鹽酸胍,嗜熱菌蛋白酶 |
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更新時間：2024-07-03 21:41:15瀏覽次數(shù)：131
聯(lián)系我們時請說明是化工儀器網(wǎng)上看到的信息，謝謝!
- 提示：詳情請下載說明書。
- 產(chǎn)品描述： Hydroxy Itraconazole (Itraconazole metabolite Hydroxy Itraconazole; R-63373) is an active metabolite of Itraconazole (ITZ), which is a triazole antifungal agent.
- 靶點： Antifungal
- 體內(nèi)研究： The plasma concentration of Hydroxy Itraconazole is weakly dependent on the dose of ITZ, most likely because the process that forms Hydroxy Itraconazole is saturated. Serum albumin and GFR may alter the pharmacokinetics of ITZ and Hydroxy Itraconazole. Antifungal activity should be discussed while taking into account not only the plasma concentration of ITZ but also that of Hydroxy Itraconazole. However, the pharmacokinetics of Hydroxy Itraconazole is similar to that of ITZ in immunocompromised patients taking an oral solution of ITZ. Since the plasma concentrations of ITZ and Hydroxy Itraconazole are closely correlated, determining the plasma concentration of either should be sufficient from a clinical point of view
- 參考文獻：
1. Mino Y, et al. Hydroxy-itraconazole pharmacokinetics is similar to that of itraconazole in immunocompromised patients receiving oral solution of itraconazole. Clin Chim Acta. 2013 Jan 16;415:128-32.
- 溶解度： DMSO : 100 mg/mL (138.58 mM; Need ultrasonic) H2O : 1 mg/mL (1.39 mM; ultrasonic and warming and heat to 80°C)
- 保存條件： 2-8℃
- 配置溶液濃度參考：
1mg 5mg 10mg 1 mM 1.413 ml 7.066 ml 14.131 ml 5 mM 0.283 ml 1.413 ml 2.826 ml 10 mM 0.141 ml 0.707 ml 1.413 ml 50 mM 0.028 ml 0.141 ml 0.283 ml
- 注意：部分產(chǎn)品我司僅能提供部分信息，我司不保證所提供信息的性，僅供客戶參考交流研究之用。
