1219168-18-9|Dorsomorphin 2HCl

本頁描述的產(chǎn)品僅供科學(xué)實(shí)驗(yàn)研究使用，不用于臨床，非醫(yī)療器械，不做其他用途。

CAS號(hào):1219168-18-9
分子式:C24H25N5O·2HCl
分子量:472.41

純度：≥98%

介紹:Dorsomorphin 2HCl是一種有效的，可逆的AMPK選擇性抑制劑，Ki為109 nM，對(duì)一些結(jié)構(gòu)相關(guān)的激酶，包括ZAPK， SYK， PKCθ， PKA和JAK3沒有顯著的抑制作用。同時(shí)抑制了BMP一型受體作用。

用途:A potent and selective AMPK inhibitor.
貯存:儲(chǔ)存溫度-20°C
可溶性:Soluble in water (100 mM), and DMSO (20 mM).
生化和生理學(xué)機(jī)理:Dorsomorphin dihydrochloride has been shown to act as a potent and selective inhibitor of AMP-activated protein kinase (AMPK; Ki = 109 nM), induced by AICAR and metformin. Dorsomorphin dihydrochloride also inhibits the bone morphogenetic protein type 1 receptors ACTR-I (ALK2), BMPR-IA (ALK3), and BMPR-IB (ALK 6). This compound is not thought to show significant activity on structurally related kinases. Dorsomorphin, Free Base, is also available .z