WNT-5a,Mouse W5A-M-005 小鼠 WNT-5a 蛋白因子

產(chǎn)品英文名稱：WNT-5a,Mouse W5A-H-005,5ug
產(chǎn)品中文名稱：小鼠 WNT-3a 蛋白因子，5ug

WNT-5a,Mouse W5A-H-005,5ug 產(chǎn)品簡介
wnt通路是細(xì)胞增殖分化的關(guān)鍵調(diào)控環(huán)節(jié)， 在胚胎發(fā)育和腫瘤發(fā)生中起著重要作用。wnt途徑參與了基因表達(dá)調(diào)節(jié)、 細(xì)胞遷移粘附、細(xì)胞極化等過程，同時還與其它信號通路存在交叉協(xié)同。Wnt/β-catenin通路在進(jìn)化過程中高度保守，此通路的主要分子構(gòu)成及相關(guān)調(diào) 控機制已得到基本闡明。對神經(jīng)系統(tǒng)而言已有足夠證據(jù)顯示此通路參與了對神經(jīng)前體細(xì)胞增殖， 分化以及決定細(xì)胞命運的調(diào)控。
Wnt-3a干細(xì)胞生長分化因子是Wnt基因家族中重要成員，zui近的一些研究發(fā)現(xiàn)， Wnt-3a信號蛋白對神經(jīng)干細(xì)胞的定向分化的調(diào)控作用表現(xiàn)的十分明顯。小鼠WNT-3a 干細(xì)胞生長分化因子蛋白包含328個氨基酸。

小鼠 WNT-3a 蛋白因子，5ug 產(chǎn)品特性
? 小鼠 WNT-3a 蛋白因子，5ug 干細(xì)胞生長分化因子活性經(jīng)過NIH 3T3 細(xì)胞鑒定，純度高
? 小鼠 WNT-3a 蛋白因子，5ug 干細(xì)胞生長分化因子生物活性在NIH 3T3 細(xì)胞經(jīng)過TCF報告基因?qū)嶒炶b定The EC50為 50–150 ng/ml
? 小鼠 WNT-3a 蛋白因子，5ug 干細(xì)胞生長分化因子產(chǎn)品經(jīng)過SDS-PAGE 和HPLC雙層鑒定純度大于90%

WNT-5a,Mouse W5A-H-005,5ug 保存方法
The lyophilized protein is stable for at least 6 months if stored at -80 degreeC. Reconstituted protein is stable for at least two weeks at 4 degree C, but should be stored in aliquots at -80 degree C for longer term. Avoid repeated freeze and thaw.

WNT-5a,Mouse W5A-H-005,5ug 產(chǎn)品英文描述
WNT-3a is a member of the WNT family of signaling proteins that play a key role in embryonic development and the integrity of adult tissues. WNT-5a,Mouse W5A-H-005,5ug is a prototypic canonical WNT that signals through the β-catenin pathway. The predicted size of mouse WNT-5a,Mouse W5A-H-005,5ug is a monomeric protein containing 333 amino acid residues. Due to glycosylation, it migrates at an apparent molecular weight of 40 kDa by SDS-PAGE analysis under nonreducing conditions. StemRD’s product WNT-5a,Mouse W5A-H-005,5ug is expressed from a mouse cell line overexpressing mouse WNT-3a. Purification is performed with a proprietary process that is distinct from the published method.
?WNT-5a,Mouse W5A-H-005,5ug Purity: Greater than 90% as determined by SDS-PAGE analysis
?WNT-5a,Mouse W5A-H-005,5ug Biological Activity: The activity was determined by using a TCF reporter gene assay in NIH3T3 cells. The EC50 ranges from 50 - 150 ng/ml. Country of Origin USA
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