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公司信息

聯(lián)人:
蔣經(jīng)理
話:
4008750250
機(jī):
18066071954
真:
址:
南京市棲霞區(qū)緯地路9號(hào)
編:
210000
個(gè)化:
www.co-bioer.com
網(wǎng)址:
www.cobioer.com/
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http://true-witness.com/st281842/
給他留言
CBP73296c-Kit A502_Y503dup/BaF3
c-Kit A502_Y503dup/BaF3
參考價(jià) 面議
具體成交價(jià)以合同協(xié)議為準(zhǔn)
  • 型號(hào) CBP73296
  • 品牌 cobioer/科佰生物
  • 廠商性質(zhì) 代理商
  • 所在地 南京市

更新時(shí)間:2022-08-01 14:51:43瀏覽次數(shù):630

聯(lián)系我們時(shí)請(qǐng)說(shuō)明是化工儀器網(wǎng)上看到的信息,謝謝!

【簡(jiǎn)單介紹】
供貨周期 現(xiàn)貨 規(guī)格 T-25 Flask
貨號(hào) CBP73296 應(yīng)用領(lǐng)域 生物產(chǎn)業(yè)
主要用途 僅限科研使用
c-Kit A502_Y503dup/BaF3,母細(xì)胞:BaF3,凍存條件:90% FBS+10% DMSO;ABL1,ABL 原癌基因 1,非受體酪氨酸激酶,通過(guò) ERK5、Rac/JNK 和 Stat1/3 通路在細(xì)胞生長(zhǎng)調(diào)節(jié)中發(fā)揮作用。已經(jīng)在各種癌癥中報(bào)道了 BCR-ABL1 融合蛋白導(dǎo)致組成型激酶活性,并且已經(jīng)證明 BCR-ABL1 背景下的許多 Abl1 突變會(huì)產(chǎn)生耐藥性。
【詳細(xì)說(shuō)明】
CBP73296
I. Introduction

Cell Line Name:

c-Kit A502_Y503dup/BaF3

Host Cell:

Ba/F3

Stability:16 passages (in-house test, that not means the cell line will be instable beyond the passages we tested.)

Freeze Medium:

90% FBS+10% DMSO

Complete Culture Medium:

RPMI-1640+10%FBS

Mycoplasma Status:

Negative


II. Background


KIT A502_Y503dup (also referred to as Y503_F504insAY) indicates the insertion of 2 duplicate amino acids, alanine (A)-502 through tyrosine (Y)-503, in the Ig-like C2-type domain 5 (exon 9) of the Kit protein . A502_Y503dup results in constitutive phosphorylation of Kit and is transforming in cell culture.


III. Representative Data

1. WB of c-Kit A502_Y503dup/BaF3


2. Sanger of c-Kit A502_Y503dup/BaF3

3. Anti-proliferation assay

Figure 4. CTG Proliferation Assay of BaF3 C-KIT A502_Y503dup Cells (C5).





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