南京科佰生物科技有限公司
主營產(chǎn)品: atcc代理,ATCC細(xì)胞系,ATCC細(xì)胞株,ATCC細(xì)胞庫購買 |
聯(lián)系電話
南京科佰生物科技有限公司
主營產(chǎn)品: atcc代理,ATCC細(xì)胞系,ATCC細(xì)胞株,ATCC細(xì)胞庫購買 |
聯(lián)系電話
參考價(jià) | 面議 |
更新時(shí)間:2022-09-19 09:33:49瀏覽次數(shù):1241
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供貨周期 | 現(xiàn)貨 | 規(guī)格 | 1ug |
---|---|---|---|
貨號 | CBP10305 | 應(yīng)用領(lǐng)域 | 生物產(chǎn)業(yè) |
CBP10305 | |
Format | Genomic DNA |
Description | MAP2K1 P124S lies within the protein kinase domain of the Map2k1 protein (UniProt.org). The functional effect of P124S is conflicting, as P124S has been reported to confer a gain of function on the Map2k1 protein as demonstrated by increased ERK1/2 phosphorylation, but has similar induction of cell proliferation and viability levels as wild-type Map2k1 (PMID: 29533785), and also confers resistance to Mek and Braf inhibitors in melanoma cells (PMID: 19915144, PMID: 22197931), |
Technical Data | |
DNA Change | c.370C>T |
AA Change | p.P124S |
Mutation type | Substitution - Missense |
Zygosity | Heterozygous |
Allelic Frequency | 50.00% |
Transcript | ENST00000307102 |
Cosmic ID | COSM235614 |
Chr position(GRCh37) | chr15:66729162 |
Buffer | Tris-EDTA |
Product Information | |
Intended Use | Research Use Only |
Unit Size | 1ug |
Concentration | Download for COA |
Purofication | Download for COA |
DNA electrophoresis | Download for COA |
Sanger sequencing | |
Storage | 4℃ |
Expiry | 36 months from the date of manufacture |