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12JZH003-Jingzhaotoxin III（JZTx-III，敬釗纓毛蛛毒素-III）
- 發(fā)布日期：
- 有效日期：
- 所 在 地：
- 產(chǎn) 地：
- 已獲點(diǎn)擊：
- 2024年10月13日
- 2025年4月13日
- 北京北京市
- 法國(guó)
- 108次
【產(chǎn)品簡(jiǎn)介】
【詳細(xì)說明】
Jingzhaotoxin III（JZTx-III，敬釗纓毛蛛毒素-III）
Selective blocker of Nav1.5 channel(鈉離子通道Nav1.5選擇性阻斷劑)
Jingzhaotoxin-III (ß-TRTX-Cj1α) has been isolated initially from the Chinese Tarantula spider Chilobrachys Jingzhaovenom. Jingzhaotoxin-III selectively inhibits the activation of the voltage-dependent sodium channel Nav1.5 with an IC50value close to 350 nM. It is inactive on Nav1.2, Nav1.4, Nav1.6 and Nav1.7 and should therefore be considered as an interesting research tool to discriminate between sodium channel subtypes. Jingzhaotoxin-III binds onto receptor site 4 presumably located on DIIS3-S4 linker of Nav1.5 and supposedly blocks Nav1.5 through a different mechanism than ProTx-II and Huwentoxin IV. ß-TRTX-Cj1α is composed of 36 amino acid residues including 6 cysteines cross-linked according to a C1-C4, C2-C5 and C3-C6 pattern. Jingzhaotoxin-III also inhibits Kv2.1 channel with an IC50 of around 700 nM.
Jingzhaotoxin-III（敬釗纓毛蛛毒素-III）技術(shù)資料
氨基酸序列：Asp-Gly-Glu-Cys4-Gly-Gly-Phe-Trp-Trp-Lys-Cys11-Gly-Arg-Gly-Lys-Pro-Pro-Cys18-Cys19-Lys-Gly-Tyr-Ala-Cys24-Ser-Lys-Thr-Trp-Gly-Trp-Cys31-Ala-Val-Glu-Ala-Pro-OH
二硫鍵： Cys4-Cys19, Cys11-Cys24, and Cys18-Cys31
長(zhǎng)度（aa）：36
分子式：C174H241N47O46S6
分子量： 3919.53 Da
外觀：White lyophilized solid
可溶性：aqueous buffer
CAS號(hào)：not available
來源：Synthetic
純度：> 98%
產(chǎn)品信息
12JZH003-00100 | JZTx-III | 0.1mg |
12JZH003-00500 | JZTx-III | 0.5mg |
12JZH003-01000 | JZTx-III | 1mg |