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07HWT001-Huwentoxin-I（虎紋捕鳥蛛神經(jīng)毒素-I）
- 發(fā)布日期：
- 有效日期：
- 所 在 地：
- 產(chǎn) 地：
- 已獲點擊：
- 2024年10月13日
- 2025年4月13日
- 北京北京市
- 法國
- 81次
【產(chǎn)品簡介】
【詳細(xì)說明】
Huwentoxin-I（虎紋捕鳥蛛神經(jīng)毒素-I）
Blocker of N-type Ca2+ channel and TTX-S channels
N型鈣通道和TTX敏感型(TTX-S)通道阻斷劑
TTX- S: 細(xì)胞河豚毒素敏感型鈉電流
Huwentoxin-I (HwTx-I) is a neurotoxin that was originally isolated from the venom of the Chinese bird spider Ornithoctonus huwena. Huwentoxin-I is known to be an inhibitor of tetrodotoxin-sensitive voltage-gated sodium channels (TTX-S) (IC50 ~ 50 nM) and N-type voltage-sensitive calcium channels (IC50 ~ 100 nM) in mammalian DRG, hippocampus and insect's DUM neurons. It has only a very weak effect on L-type calcium channels, no effect on TTX-R channels and has virtually no effect on muscle sodium channels. The selectivity of Huwentoxin-I for calcium channels appears to be higher than ω-conotoxin MVIIA and equivalent to ω-conotoxin GVIA. Huwentoxin-I demonstrated an antinociceptive effect in the rat model of the formalin test when administrated intrathecally (ED50 ~ 0.28 µg/kg), without side effects of the ones led by ω-conotoxin MVIIA.
Huwentoxin-I 技術(shù)資料
氨基酸序列：
Ala-Cys2-Lys-Gly-Val-Phe-Asp-Ala-Cys9-Thr-Pro-Gly-Lys-Asn-Glu-Cys16-Cys17-Pro-Asn-Arg-Val-Cys22-Ser-Asp-Lys-His-Lys-Trp-Cys26-Lys-Trp-Lys-Leu-OH
二硫鍵： Cys2-Cys17, Cys9-Cys22 and Cys16-Cys29
長度 (aa)：33
分子式：C168H250N46O41S6
分子量： 3751.77 Da
外觀：White lyophilized solid
可溶性：water and saline buffer
CAS 號：not available
來源： Synthetic
純度： > 97 %
產(chǎn)品信息
07HWT001-00100 | Huwentoxin-I | 0.1mg |
07HWT001-00500 | Huwentoxin-I | 0.5mg |
07HWT001-01000 | Huwentoxin-I | 1mg |