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13HTX003-Hainantoxin-III（海南捕鳥(niǎo)蛛毒素-Ⅲ）
- 發(fā)布日期：
- 有效日期：
- 所 在 地：
- 產(chǎn) 地：
- 已獲點(diǎn)擊：
- 2024年10月13日
- 2025年4月13日
- 北京北京市
- 法國(guó)
- 122次
【產(chǎn)品簡(jiǎn)介】
【詳細(xì)說(shuō)明】
Hainantoxin-III（海南捕鳥(niǎo)蛛毒素 III）
Selective blocker of TTX-S VGSC(電壓門(mén)控鈉離子通道TTX-S選擇性阻斷劑)
Hainantoxin-III (HNTX-III) is a peptide that has been isolated from the venom of the Chinese bird spider Seleconosmia hainana. Hainantoxin-III specifically blocks mammalian neuronal tetrodotoxin-sensitive voltage-gated sodium channels (VGSCs). Hainantoxin III was found inactive on tetrodotoxin-resistant VGSCs and voltage-gated Ca2+channels (both high and low voltage-activated).
Hainantoxin-III strongly depressed the amplitude of rat DRG tetrodotoxin-sensitive Na+ currents with an IC50 value of 1.1 nM. Like Hainantoxin-IV, Hainantoxin-III causes a hyperpolarizing shift of about 10 mV in the voltage midpoint of steady-state Na+ channel inactivation. Similar to Huwentoxin-IV, Hainantoxin-III and Hainantoxin-IV do not affect the activation and inactivation kinetics of Na+ currents.
Hainantoxin-III inhibits Nav1.7 current amplitude without significantly altering the activation and inactivation kinetics.Hainantoxin-III increases the deactivation of the Nav1.7 current after extreme depolarizations. Hainantoxin-III seems to interact with site 4 and to trap the domain II voltage sensor in the closed state. The inhibition of Nav1.7 by hainantoxin-III is reversible upon washing, but no reversibility was observed for Hainantoxin-IV and Huwentoxin-IV.
Hainantoxin-III was shown to block Nav1.1, Nav1.2, Nav1.3 and Nav1.7 expressed in HEK293 cells with IC50 values of 1.27 µM, 275 nM, 491 nM and 232 nM, respectively.
Hainantoxin-III 技術(shù)資料
氨基酸序列：
Gly-Cys2-Lys-Gly-Phe-Gly-Asp-Ser-Cys9-Thr-Pro-Gly-Lys-Asn-Glu-Cys16-Cys17-Pro-Asn-Tyr-Ala-Cys22-Ser-Ser-Lys-His-Lys-Trp-Cys29-Lys-Val-Tyr-Leu-NH2
二硫鍵：Cys2-Cys17, Cys9-Cys22, and Cys16-Cys29
長(zhǎng)度 (aa)： 33
分子式： C154H228N44O45S6
分子量：3608.20 Da
外觀(guān)： White lyophilized solid
可溶性：water and saline buffer
CAS 號(hào)：Not available
來(lái)源：Synthetic
純度： > 97%
產(chǎn)品信息
13HTX003-00100 | Hainantoxin III | 0.1mg |
13HTX003-00500 | Hainantoxin III | 0.5mg |
13HTX003-01000 | Hainantoxin III | 1mg |