粘附相關(guān)激酶抗體 返回列表頁(yè)

英文名稱 AXL
中文名稱 粘附相關(guān)激酶抗體
別    名 Adhesion related kinase; AI323647; Ark; Axl; AXL oncogene; AXL receptor tyrosine kinase; AXL transforming gene; AXL transforming sequence/gene; EC 2.7.10.1; JTK11; Oncogene AXL; Tyro7; Tyrosine protein kinase receptor UFO; Tyrosine-protein kinase receptor UFO; UFO; UFO_HUMAN.
粘附相關(guān)激酶抗體
 
說 明 書 0.1ml  0.2ml  
研究領(lǐng)域 腫瘤  細(xì)胞生物  免疫學(xué)  信號(hào)轉(zhuǎn)導(dǎo)  細(xì)胞周期蛋白  激酶和磷酸酶  細(xì)胞膜受體  細(xì)胞類型標(biāo)志物  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應(yīng) Human, Mouse, Rat, Dog, Horse, Rabbit, 
產(chǎn)品應(yīng)用 WB=1:100-500 ELISA=1:500-1000 IP=1:20-100 IHC-P=1:100-500 IHC-F=1:100-500 Flow-Cyt=1:100-500 IF=1:100-500 （石蠟切片需做抗原修復(fù)）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 95kDa
細(xì)胞定位 細(xì)胞膜 
性    狀 Lyophilized or Liquid
濃    度 1mg/1ml
免 疫 原 KLH conjugated synthetic peptide derived from human AXL
亞    型 IgG
純化方法 affinity purified by Protein A
儲(chǔ) 存 液 0.01M PBS, pH 7.4 with 10 mg/ml BSA and 0.1% Sodium azide
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.

產(chǎn)品介紹 background:
The protein encoded by this gene is a member of the receptor tyrosine kinase subfamily. Although it is similar to other receptor tyrosine kinases, the Axl protein represents a unique structure of the extracellular region that juxtaposes IgL and FNIII repeats. It transduces signals from the extracellular matrix into the cytoplasm by binding growth factors such as vitamin K dependent protein growth arrest specific gene 6. It is involved in the stimulation of cell proliferation. This receptor can also mediate cell aggregation by homophilic binding. Axl is a chronic myelogenous leukemia associated oncogene and also associated with colon cancer and melanoma.The Axl gene is evolutionarily conserved between vertebrate species. This gene has two different alternatively spliced transcript variants (AXL1 and AXL2).

Function:
Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding growth factor GAS6 and which is thus regulating many physiological processes including cell survival, cell proliferation, migration and differentiation. Ligand binding at the cell surface induces dimerization and autophosphorylation of AXL. Following activation by ligand, ALX binds and induces tyrosine phosphorylation of PI3-kinase subunits PIK3R1, PIK3R2 and PIK3R3; but also GRB2, PLCG1, LCK and PTPN11. Other downstream substrate candidates for AXL are CBL, NCK2, SOCS1 and TENC1. Recruitment of GRB2 and phosphatidylinositol-3 kinase regulatory subunits by AXL leads to the downstream activation of the AKT kinase. GAS6/AXL signaling plays a role in various processes such as endothelial cell survival during acidification by preventing apoptosis, optimal cytokine signaling during human natural killer cell development, hepatic regeneration, gonadotropin-releasing hormone neuron survival and migration, plaet activation, or regulation of thrombotic responses. Plays also an important role in inhibition of Toll-like receptors (TLRs)-mediated innate immune response. In case of filovirus infection, seems to function as a cell entry factor.

Subunit:
Heterodimer and heterotetramer with ligand GAS6. Interacts with CBL, GRB2, LCK, NCK2, PIK3R1, PIK3R2, PIK3R3, PLCG1, SOCS1 and TENC1. Part a complex including AXL, TNK2 and GRB2, in which GRB2 promotes AXL recruitment by TNK2.

Subcellular Location:
Cell membrane; Single-pass type I membrane protein.

Tissue Specificity:
Highly expressed in metastatic colon tumors. Expressed in primary colon tumors. Weakly expressed in normal colon tissue.

Post-translational modifications:
Phosphorylated at tyrosine residues by autocatalysis, which activates kinase activity.

DISEASE:
Note=AXL and its ligand GAS6 are highly expressed in thyroid carcinoma tissues, and might thus be involved in thiroid tumorigenesis. Overexpression of AXL and its ligand was also detected in many other cancers such as myeloptoliferative disorders, prostatic carcinoma cells, or breast cancer.

Similarity:
Belongs to the protein kinase superfamily. Tyr protein kinase family. AXL/UFO subfamily.
Contains 2 fibronectin type-III domains.
Contains 2 Ig-like C2-type (immunoglobulin-like) domains.
Contains 1 protein kinase domain

Database links:

Entrez Gene: 558 Human

Omim: 109135 Human

SwissProt: P30530 Human
xy-0569R CDK7周期素依賴性激酶7抗體
xy-0570R CDK8周期素依賴性激酶8抗體
xy-0538R CDKN1C周期蛋白依賴激酶抑制因子1C抗體
xy-4850R ChondrocalcinⅡ型膠原α1蛋白/軟骨鈣素抗體
xy-0469R c-fosc-fos抗體
xy-0539R Chromogranin A嗜鉻粒素A抗體
xy-0791R CGRPCGRP降鈣素基因相關(guān)肽抗體
xy-0042R ChATChAT膽堿乙酰轉(zhuǎn)移酶抗體
xy-9740R CNTD2細(xì)胞周期蛋白N端結(jié)構(gòu)域蛋白2抗體
xy-8550R Coronin 1a肌動(dòng)蛋白結(jié)合蛋白CORO1A抗體
xy-2080R Cecropin抗菌肽/天蠶素抗體
xy-1809R Camk1g鈣/鈣調(diào)蛋白依賴蛋白激酶IG抗體
xy-1679R CCR8細(xì)胞表面趨化因子受體8抗體
xy-0262R CMTM2趨化素樣因子超家族成員2抗體
xy-9515R CTH胱硫醚γ裂解酶抗體
xy-1277R CFTR囊性纖維化跨膜轉(zhuǎn)運(yùn)調(diào)節(jié)因子抗體
xy-1330R CKIP-1酪蛋白激酶2相互作用蛋白1抗體
xy-1286R CD40LCD40L抗體
xy-10033R Alpha s1 Caseinα-s1酪蛋白抗體
xy-0716R CIDEBCIDEB抗體
xy-1186R Scavenging Receptor SR-BI高密度脂蛋白受體/清道夫受體抗體
xy-9124R COPS7A信號(hào)轉(zhuǎn)導(dǎo)蛋白亞基7A抗體

Unigene: 590970 Human