Amyloid beta （A4） Precursor Protein （APP） （AA 666- 返回列表頁

Amyloid beta (A4) Precursor Protein (APP) (AA 666-670) 抗體

抗原
Amyloid beta (A4) Precursor Protein (APP)
別名
APP, APP-like, APPL, Abeta, BcDNA:GH04413, CG7727, DmelCG7727, EG:65F1.5, appl, aaa, abeta, abpp, ad1, appi, ctfgamma, cvap, pn2, AAA, ABETA, ABPP, AD1, APPI, CTFgamma, CVAP, PN-II, PN2, Abpp, Adap, ... show more
抗原表位
 其他選擇AA 666-670
適用
 其他選擇Human, Murine, Rat (Rattus)
宿主
 其他選擇Rabbit
克隆類型
多克隆抗體
標記
 其他選擇非結(jié)合性
應用范圍
 其他選擇Immunocytochemistry (ICC), Immunofluorescence (IF), Western Blotting (WB)
[Pubmed] 4 references available
規(guī)格 50 μg
發(fā)貨至 中國 (Change)
發(fā)貨時間 29至35個工作日

產(chǎn)品編號 ABIN197433

Amyloid beta (A4) Precursor Protein (APP) (AA 666-670) 抗體

產(chǎn)品細節(jié)

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免疫原 peptide Sequence around amino acids 666~670 (A-V-T-P-E) derived from Human APP protein.
特異性 This antibody detects endogenous levels of total APP protein.
純化方法 Affinity Chromatography using epitope-specific immunogen.

Amyloid beta (A4) Precursor Protein (APP) (AA 666-670) 抗體目標詳細情況

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別名 Amyloid beta A4 protein / APP
背景 Amyloid beta precursor protein gene (ABPP) encodes a cell surface receptor and transmembrane precursor protein that is cleaved by secretases to form a number of peptides. Multiple transcript variants encoding several different isoforms have been found for this gene. Isoform APP695 is the predominant form in neuronal tissue, isoform APP751 and isoform APP770 are widely expressed in nonneuronal cells. Isoform APP751 is the most abundant form in T lymphocytes. ABPP is expressed in all fetal tissues examined with the highest levels in brain, kidney, heart and spleen with weak expression observed in liver, ABPP is induced during neuronal differentiation. In the adult brain, highest expression of ABPP gene is found in the frontal lobe of the cortex and in the anterior perisylvian cortex opercular gyri, moderate expression in the cerebellar cortex, the posterior perisylvian cortex opercular gyri and the temporal associated cortex. Weak expression is found in the striate, extra striate and motor cortices. Mutations in ABPP have been implicated in autosomal dominant Alzheimer disease and cerebroarterial amyloidosis (cerebral amyloid angiopathy).
Alternate names: ABPP, APPI, Alzheimer disease amyloid protein, Amyloid Precursor Protein, CVAP, Cerebral vascular amyloid peptide, PreA4, Protease nexin-II
基因ID 351
NCBI Accession NP_000475
UniProt P05067
研究領(lǐng)域 Neurology, Alzheimer's Disease

使用細節(jié)

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應用備注 Western Blot: 1/500-1/1000. Immunofluorescence: 1/100-1/200. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
限制 For Research Use only

Amyloid beta (A4) Precursor Protein (APP) (AA 666-670) 抗體貯存及處理

引用圖像使用細節(jié)目標詳細情況回頁首
狀態(tài) Liquid
濃度 1.0 mg/mL
緩沖液 PBS (without Mg2+ and Ca2+), pH 7.4 containing 150mM NaCl, 0.02% Sodium Azide and 50% Glycerol.
儲存液 Sodium azide
注意事項 This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
注意事項 Avoid repeated freezing and thawing.
儲存條件 -20 °C
儲存方法 Store the antibody (in aliquots) at -20°C.
有效期 12 months

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