A激酶錨定蛋白5抗體 返回列表頁

英文名稱 AKAP5
中文名稱 A激酶錨定蛋白5抗體
別    名 A kinase (PRKA) anchor protein 5; A kinase anchor protein 5; A kinase anchor protein 79kDa; A kinase anchoring protein 75/79; A-kinase anchor protein 5; A-kinase anchor protein 79 kDa; AKAP 5; AKAP 75; AKAP 79; AKAP-5; Akap5; AKAP5_HUMAN; AKAP75; AKAP79; cAMP dependent protein kinase regulatory subunit II high affinity binding protein; cAMP-dependent protein kinase regulatory subunit II high affinity-binding protein; H21.
A激酶錨定蛋白5抗體
  
說 明 書 0.2ml  
研究領(lǐng)域 細(xì)胞生物  免疫學(xué)  神經(jīng)生物學(xué)  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應(yīng) Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit, 
產(chǎn)品應(yīng)用 WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:50-200 （石蠟切片需做抗原修復(fù)）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 47/79(human/rat, mo)kDa
細(xì)胞定位 細(xì)胞膜 
性    狀 Lyophilized or Liquid
濃    度 1mg/1ml
免 疫 原 KLH conjugated synthetic peptide derived from human AKAP5
亞    型 IgG
純化方法 affinity purified by Protein A
儲(chǔ) 存 液 Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.


產(chǎn)品介紹 background:
The type II cAMP-protein kinase (PKA) is a multifunctional kinase with a broad range of substrates (1). Specificity of PKA signaling is thought to be mediated by the compartmentalization of the kinase to specific sites within the cell. To maintain this specific localization, the R subunit (RII) of PKA interacts with specific RII-anchoring proteins. This family of proteins has been designated A-kinase anchoring proteins (AKAP) (1-3). Members of this family, including MAP2 (microtubule-associated protein 2), neuronally expressed AKAP 79 and AKAP 150, and the DNA binding AKAP 95, display differential tissue specificity and localization (4-6). Evidence suggests that AKAP 79 and AKAP 150 are both capable of anchoring PKA to postsynaptic densities (PSD), which are a network of proteins located on the internal surfaces of excitatory synapses。

Function:
May anchor the PKA protein to cytoskeletal and/or organelle-associated proteins, targeting the signal carried by cAMP to specific intracellular effectors. Association with to the beta2-adrenergic receptor (beta2-AR) not only regulates beta2-AR signaling pathway, but also the activation by PKA by switching off the beta2-AR signaling cascade.

Subunit:
Binding protein for dimer of the RII-beta regulatory subunit of cAMP-dependent protein kinase (PKA) and also for the protein kinase C (PKC) and the phosphatase calcineurin (PP2B). Each enzyme is inhibited when bound to the anchoring protein. Also binds the beta2-adrenergic receptor. Part of a complex containing AKAP5, ADCY5, ADCY6 AND PDE4C (By similarity). Interacts with ADCY8, and enhances its phosphorylation at lipid rafts.

Subcellular Location:
Membrane; Lipid-anchor.

Tissue Specificity:
Predominantly in the cerebral cortex and the postsynaptic densities of the forebrain, and to a lesser extent in adrenal medulla, lung and anterior pituitary.

Post-translational modifications:
Palmitoylation at Cys-36 and Cys-129 plays a key role in targeting to lipid rafts.

Similarity:
Contains 1 AKAP domain.

Database links:
UniProtKB/Swiss-Prot: P24588.3

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
xy-4011R ATG9B自噬相關(guān)蛋白9B抗體
xy-4012R Apg12自噬相關(guān)蛋白12抗體
xy-3864R ATG13自噬相關(guān)蛋白13抗體
xy-4013R ATG3自噬相關(guān)蛋白3抗體
xy-4191R ADAMTS4整合素樣金屬蛋白酶與凝血酶4型抗體
xy-1648R phospho-ATF2 (Ser490/498)磷酸化活化復(fù)制因子2抗體
xy-1649R phospho-Amyloid Precursor Protein (Tyr757)磷酸化APP(Tyr757)淀粉樣肽前體蛋白抗體
xy-2919R ACTR絲氨酸/蘇氨酸蛋白激酶ATR抗體
xy-5849R ADAM18去整合素樣金屬蛋白酶18抗體
xy-1634R ATF6活化轉(zhuǎn)錄因子6抗體
xy-1546R AP2 beta銜接蛋白β抗體
xy-1600R Gamma-Adaptin銜接蛋白γ/γ-Adaptin抗體
xy-2060R AQP9水通道蛋白-9抗體
xy-1631R Annexin A3膜粘連蛋白A3抗體
xy-1564R Annexin IV膜粘連蛋白 A4抗體
xy-12487R APG8A自噬相關(guān)蛋白8A抗體
xy-3043R phospho-Akt (Thr450)磷酸化蛋白激酶B抗體
xy-5551R phospho-AMPK alpha-1 (Thr198)磷酸化腺苷單磷酸活化蛋白激酶α1抗體
xy-2720R phospho-Akt(Thr308)磷酸化蛋白激酶B抗體
xy-15407R APOBEC3G脫氧胞苷脫氨酶蛋白抗體
xy-13637R AKAP13蛋白激酶錨定蛋白13抗體
xy-13638R AP1M2AP-1μ2抗體
xy-7348R Allergin-1肥大細(xì)胞膜抑制性受體Allergin1抗體
xy-4915R ACCN1腦鈉通道蛋白1抗體
xy-10563R ARP2/3 subunit 1B肌動(dòng)蛋白相關(guān)蛋白2/3復(fù)合亞單位B1抗體
xy-4780R ABCG2三磷酸腺苷結(jié)合轉(zhuǎn)運(yùn)蛋白G超家族成員2抗體