感染性蛋白*蛋白1抗體 返回列表頁(yè)

英文名稱 POP1
中文名稱 感染性蛋白*蛋白1抗體
別    名 PAAD domain only protein; POP1; PYDC1; Pyrin domain containing 1; Pyrin only protein 1; PYDC1_HUMAN.
感染性蛋白*蛋白1抗體  
說(shuō) 明 書(shū) 0.1ml  0.2ml  
研究領(lǐng)域 細(xì)胞生物  免疫學(xué)  
抗體來(lái)源 Rabbit
克隆類型 Polyclonal
交叉反應(yīng) Human, Mouse, Rat, Pig, Cow, Horse, 
產(chǎn)品應(yīng)用 WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:50-200 （石蠟切片需做抗原修復(fù)）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 10kDa
細(xì)胞定位 細(xì)胞漿 
性    狀 Lyophilized or Liquid
濃    度 1mg/1ml
免 疫 原 KLH conjugated synthetic peptide derived from human ASC2/POP1
亞    型 IgG
純化方法 affinity purified by Protein A
儲(chǔ) 存 液 Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產(chǎn)品介紹 background:
The death domain (DD) superfamily of proteins share one or more of the following domains: the DD, DED (death-effector domain), CARD (caspase-recruitment domain) and PYD (Pyrin domain). Each of these domains is characterized by a canonical death domain fold, which consists of a bundle of five or six antiparallel α-helices. As their names suggest, these domains play prominent roles in programmed cell death. ASC2 (apoptosis-associated speck-like protein containing a CARD 2), also known as Pyrin-only protein 1 or PADD-only protein 1, is an 89 amino acid member of the DD superfamily that contains one Pyrin domain. Localized to the cytoplasm, ASC2 interacts with ASC to modulate NF-κB and pro-caspase-1 regulation. ASC2 is predominantly expressed in monocytes, macrophages and granulocytes.

Function:
Associates with apoptosis-associated specklike proteincontaining a CARD domain (ASC) and modulates its ability tocollaborate with pyrin and cryopyrin in NF-kappa-B andpro-caspase-1 activation. Suppresses kinase activity of NF-kappa-Binhibitor kinase (IKK) complex, expression of NF-kappa-B induciblegenes and inhibits NF-kappa-B activation by cytokines and LPS.

Subunit:
Interacts with PYCARD/ASC.

Subcellular Location:
Cytoplasm.

Tissue Specificity:
Predominantly expressed in monocytes,macrophages and granulocytes.

Post-translational modifications:
Phosphorylated.

Similarity:
Contains 1 DAPIN domain.

Database links:
UniProtKB/Swiss-Prot: Q8C3.1

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.xy-9551R BEND2BEND2蛋白抗體
xy-4729R Bone Sialoprotein骨涎蛋白
xy-8876R Vibrio Parahemolyticus Polar flagellin B/D副溶血性弧菌菌體鞭毛蛋白抗體
xy-8159R BTBD6BTBD6蛋白抗體
xy-6910R BMPERBMP內(nèi)皮細(xì)胞調(diào)節(jié)蛋白抗體
xy-8158R HCV NS5A transactivated protein 8丙肝病毒NS5A反轉(zhuǎn)錄蛋白8抗體
xy-6401R BMP1骨形態(tài)發(fā)生蛋白1/膠原C蛋白肽鏈內(nèi)切酶抗體
xy-6909R BMP9骨形態(tài)發(fā)生蛋白9抗體
xy-7849R Beta tubulin cofactor D微管蛋白β輔助因子D抗體
xy-13714R BTR1鈣粘蛋白相關(guān)蛋白受體BTR1抗體
xy-7835R Bub3有絲分裂蛋白BUB3抗體
xy-11653R BHLHB9/p60TRPp60TRP蛋白抗體
xy-11654R BLMH博萊霉素水解酶抗體
xy-11655R Aggrecan短蛋白聚糖抗體
xy-8397R BTBD3BTB/POZ結(jié)構(gòu)域蛋白3抗體
xy-11505R BBS12巴爾得-別德?tīng)柧C合征相關(guān)蛋白12抗體
xy-12903R BZW1堿性亮氨酸拉鏈蛋白BZW1抗體
xy-6639R BMPR1B骨形態(tài)發(fā)生蛋白受體1B抗體
xy-6681R BNIP1Bcl2相互作用蛋白1抗體（轉(zhuǎn)化相關(guān)基因8蛋白）
xy-6614R BMP5骨形態(tài)發(fā)生蛋白5抗體
xy-6612R BMP15骨形態(tài)發(fā)生蛋白15抗體
xy-5903R Bcl2L2Bcl-2樣蛋白2抗體
xy-4292R BPI殺菌/通透性增強(qiáng)蛋白抗體