AKIRIN1蛋白抗體 返回列表頁

英文名稱 AKIRIN1
中文名稱 AKIRIN1蛋白抗體
別    名 AKIRIN 1; C1orf108; FLJ12666; OTTHUMP00000008669; RP11-781D11.2; STRF2; AKIR1_HUMAN.
AKIRIN1蛋白抗體
說 明 書 0.1ml  0.2ml  
研究領(lǐng)域 細(xì)胞生物  免疫學(xué)  表觀遺傳學(xué)  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應(yīng) Human, Mouse, Rat, Dog, Horse, Sheep, 
產(chǎn)品應(yīng)用 WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:50-200 （石蠟切片需做抗原修復(fù)）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 22kDa
細(xì)胞定位 細(xì)胞核 
性    狀 Lyophilized or Liquid
濃    度 1mg/1ml
免 疫 原 KLH conjugated synthetic peptide derived from human AKIRIN1
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產(chǎn)品介紹 background:
AKIRIN1 is dispensable in the mouse, and neither knockout mice nor cells derived from them have obvious distinctive phenotypes. In contrast, Akirin2 is required for development in the mouse and knockout of both Akirin homologs in mice show that Akirin2 is required downstream of toll-like receptor (TLR), TNF-alpha and IL-1beta signaling, and for the production of IL-6. Akirin2 is functionally closer to the single gene in Drosophila, as the homozygous null D. melanogaster Akirin mutants show a similar, mid-to-early embryonic death.The highly conserved, nuclear-localized AKIRIN1 and Akirin2 proteins critically regulate the transcription of NF-kB dependent genes and are required for defense against Gram-negative bacteria in the immune deficiency and NF-kB pathways.

Subcellular Location:
Nuclear

Tissue Specificity:
Widely expressed with the highest expression in heart, liver, placenta and peripheral blood leukocytes.

Similarity:
Belongs to the akirin family.

Database links:
UniProtKB/Swiss-Prot: Q9H9L7.1

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.xy-1015R BRMS-1乳腺癌轉(zhuǎn)移抑制基因1抗體
xy-0292R BSA牛血清白蛋白抗體
xy-0466R Beta-caseinβ-酪蛋白抗體
xy-2455R beta Glucan Receptorβ葡聚糖受體抗體
xy-2143R Batroxobin蛇毒蛋白巴曲酶抗體
xy-2765R BMX非受體性蛋白酪氨酸激酶ETK抗體
xy-3132R Phospho-BMX (Tyr40)磷酸化非受體性蛋白酪氨酸激酶ETK抗體
xy-0893R phospho-BAD (Ser128)磷酸化相關(guān)死亡促進(jìn)因子抗體
xy-8521R BarX1BarX1蛋白抗體
xy-7622R B3GALNT1β1，3半乳糖轉(zhuǎn)移酶3抗體
xy-7620R Band3紅細(xì)胞陰離子交換蛋白1抗體
xy-6985R BRN3B腦特定蛋白Brn3B抗體
xy-1353R Beclin 1Bcl-2同源結(jié)構(gòu)域蛋白抗體
xy-1374R BMP4骨形態(tài)發(fā)生蛋白4抗體
xy-9849R BAALC腦和急性白血病胞漿蛋白抗體
xy-9850R BST2骨髓基質(zhì)干細(xì)胞抗原2抗體
xy-2999R BMI1組蛋白相關(guān)Bmi1抗體
xy-8686R BRMS1乳腺癌轉(zhuǎn)移抑制基因1抗體
xy-11335R BEGAIN大腦富含鳥苷酸激酶相關(guān)蛋白抗體
xy-8662R BASP1腦富含膜附著信號蛋白1抗體
xy-11042R Bestrophin 3卵黃狀黃斑病蛋白3抗體
xy-11040R Bestrophin卵黃狀黃斑病蛋白抗體
xy-11043R Bestrophin 4卵黃狀黃斑病蛋白4抗體
xy-4948R Bacillus anthraci protein炭疽桿菌菌體蛋白抗體
xy-4500R BRLF1EBV立即早期基因BRLF1抗體
xy-7978R BEX4腦表達(dá)X連鎖蛋白4抗體