含錨蛋白重復序列-細胞因子信號抑制物盒蛋白家族12抗體 返回列表頁

英文名稱 ASB12
中文名稱 含錨蛋白重復序列-細胞因子信號抑制物盒蛋白家族12抗體
別    名 ankyrin repeat and SOCS box-containing 12; ankyrin repeat and SOCS box-containing protein 12; ankyrin repeat domain-containing SOCS box protein Asb-12; ASB12; FLJ39577; ASB12_HUMAN.
含錨蛋白重復序列-細胞因子信號抑制物盒蛋白家族12抗體  
說 明 書 0.2ml  
研究領域 細胞生物  免疫學  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應 Human, Mouse, Rat, Dog, Cow, Rabbit, Sheep, 
產(chǎn)品應用 WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:50-200 （石蠟切片需做抗原修復）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 34kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/1ml
免 疫 原 KLH conjugated synthetic peptide derived from human ASB12
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產(chǎn)品介紹 background:
Members of the suppressor of cytokine signaling (SOCS) family of proteins contain C-terminal regions of homology called the SOCS box, which serves to couple SOCS proteins and their binding partners with the Elongin B/C complex. Several other families of proteins also contain SOCS boxes, but differ from the SOCS proteins in the type of domain they contain upstream of the SOCS box. The largest family of SOCS box-containing proteins is the ankyrin repeat and SOCS box-containing (ASB) protein family. ASB-12 (ankyrin repeat and SOCS box-containing 12) is ag 309 amino acid member of the ASB family that contains one SOCS box domain and five ANK repeats. ASB-12 functions as a substrate-recognition component of an E3 ubiquitin-protein ligase complex and, working in conjunction with other proteins, plays a role in the ubiquitination and subsequent proteasomal degradation of target proteins.

Function:
Probable substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (By similarity).

Subunit:
Interacts with CUL5 and RNF7.

Similarity:
Contains 5 ANK repeats.
Contains 1 SOCS box domain.

Database links:
UniProtKB/Swiss-Prot: Q8K4.2

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.xy-1489R BIRC6Apollon凋亡抑制蛋白抗體
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