含錨蛋白重復序列-細胞因子信號抑制物盒蛋白家族4抗體 返回列表頁

英文名稱 ASB4
中文名稱 含錨蛋白重復序列-細胞因子信號抑制物盒蛋白家族4抗體
別    名 Ankyrin repeat and SOCS box containing 4; Ankyrin repeat and SOCS box containing protein 4; Ankyrin repeat and SOCS box protein 4; ASB 4; ASB-4; ASB4; ASB4_HUMAN.
含錨蛋白重復序列-細胞因子信號抑制物盒蛋白家族4抗體說 明 書 0.2ml  
研究領域 細胞生物  免疫學  細胞周期蛋白  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應 Human, Mouse, Rat, Dog, Pig, Cow, Horse, Sheep, 
產品應用 WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:50-200 （石蠟切片需做抗原修復）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 48kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/1ml
免 疫 原 KLH conjugated synthetic peptide derived from human ASB4
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產品介紹 background:
Probable substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.

Function:
Probable substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Promotes differentiation and maturation of the vascular lineage by an oxygen-dependent mechanism (By similarity).

Subunit:
Interacts with HIF1AN. Component of an ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex formed of CUL2 or CUL5, Elongin BC (TCEB1 and TCEB2), RBX1 and ASB4.

Post-translational modifications:
Hydroxylation at Asn-246 by HIF1AN may provide an oxygen-dependent regulation mechanism for the function of ASB4 in promoting vascular differentiation (By similarity).

Similarity:
Contains 6 ANK repeats.
Contains 1 SOCS box domain.

Database links:
UniProtKB/Swiss-Prot: Q9Y574.1

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.xy-7980R beta glucuronidaseβ葡萄糖醛酸苷酶抗體
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