3號(hào)染色體開(kāi)放閱讀框15抗體 返回列表頁(yè)

英文名稱 C3orf15
中文名稱 3號(hào)染色體開(kāi)放閱讀框15抗體
別    名 AAT 1; AAT-1; AAT1; AAT1 alpha; AAT1_HUMAN; AAT1alpha; AMY 1 associating protein expressed in testis 1; AMY-1-associating protein expressed in testis 1; Chromosome 3 open reading frame 15; MYCBP binding protein.
 3號(hào)染色體開(kāi)放閱讀框15抗體  
說(shuō) 明 書(shū) 0.2ml  
研究領(lǐng)域 細(xì)胞生物  免疫學(xué)  細(xì)胞分化  
抗體來(lái)源 Rabbit
克隆類型 Polyclonal
交叉反應(yīng) Human, Mouse, Rat, 
產(chǎn)品應(yīng)用 WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:50-200 IEM=1:20-200 IGS=1:20-200 GICA=1:20-200 （石蠟切片需做抗原修復(fù)）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 71kDa
細(xì)胞定位 細(xì)胞漿 
性    狀 Lyophilized or Liquid
濃    度 1mg/1ml
免 疫 原 KLH conjugated synthetic peptide derived from human AAT1/C3orf15
亞    型 IgG
純化方法 affinity purified by Protein A
儲(chǔ) 存 液 Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
 產(chǎn)品介紹 background:
The c-Myc proto-oncogene plays a significant role in cell proliferation, differentiation, transformation and apoptosis. A novel c-Myc binding protein, MYCBP (also designated AMY-1), binds to the transactivation domain of c-Myc and stimulates the activation of E-box-dependent transcription. MYCBP translocates from the cytoplasm to the nucleus during S phase when increased expression of c-Myc occurs. MYCBP and AAT-1 (AMY-1-associating protein expressed in testis 1) have been shown to associate with AKAP 149 and AKAP 84 in mitochondria of somatic cells and sperm, which suggests a role for MYCBP and AAT-1 in spermatogenesis. Expression of the AAT-1 gene is regulated by two different promoters, which result in various isoforms. One promoter generates expression of the AAT-1, AAT-1å, AAT-1∫ and AAT-1© isoforms, which are specifically expressed in testis, while the other promoter generates AAT-1L, AAT-1M and AAT-1S, which are differentially expressed.

Function:
Isoform 4 may play a role in spermatogenesis.

Subunit:
Interacts with MYCBP and AKAP1. Isoform 4 is part of a complex containing MYCBP, AKAP1 and PRKAR2B. Isoform 3 does not interact with MYCBP.

Subcellular Location:
Cytoplasm. Mitochondrion. Isoform 4 is found in the mitochondria and localized in the neck of the sperm.

Tissue Specificity:
Isoform 1 is strongly expressed in the liver. Isoform 4 is widely expressed, but strongly expressed in all spermatogenesis-related tissues, including the testis, the epithelium of cauda and the corpus epididymis. Isoform 4 is present in the spermatid and mature sperm. Isoform 4 is also expressed in Leydig cells. Isoform 3 is expressed in the testis.

Similarity:
Isoform 4 is phosphorylated by PKA.

Database links:

Entrez Gene: 89876 Human

Omim: 609910 Human

SwissProt: Q7Z4T9 Human

Unigene: 341906 Human

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. xy-E10281 【中文名稱】：人鱗狀細(xì)胞癌相關(guān)抗原(SCCAg)ELISA試劑盒 【英文名稱】：Human squamous cell carcinoma associated antigen (SCCAg) ELISA kit 【靈敏度】：9.375pg/mL
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xy-E10283 【中文名稱】：人黑色素瘤轉(zhuǎn)移表面黏附分子(MMSAM)ELISA試劑盒 【英文名稱】：Human melanoma metastasis surface adhesion molecules (MMSAM) ELISA kit 【靈敏度】：9.375pg/mL
xy-E10284 【中文名稱】：人乳腺癌易感蛋白2(BRCA-2)ELISA試劑盒 【英文名稱】：Human breast cancer susceptibility protein 2 (BRCA-2) ELISA Kit 【靈敏度】：9.375pg/mL
xy-E10285 【中文名稱】：人凋亡信號(hào)調(diào)節(jié)激酶I(ASK-1)ELISA試劑盒 【英文名稱】：Apoptosis signal-regulated kinase I (ASK-1) ELISA Kit 【靈敏度】：9.375pg/mL
xy-E10286 【中文名稱】：人Bcl-2相關(guān)X蛋白(BAX)ELISA試劑盒 【英文名稱】：Human Bcl-2 -related X protein (BAX) ELISA kit 【靈敏度】：9.375pg/mL
xy-E10287 【中文名稱】：人轉(zhuǎn)移因子(TF)ELISA試劑盒 【英文名稱】：Who transfer factor (TF) ELISA kit 【靈敏度】：9.375pg/mL
xy-E10288 【中文名稱】：人結(jié)腸癌抗原(CCA)ELISA試劑盒 【英文名稱】：Human colon carcinoma antigen (CCA) ELISA Kit 【靈敏度】：9.375pg/mL
xy-E10289 【中文名稱】：人H-ras ELISA試劑盒 【英文名稱】：Human H-ras ELISA kit 【靈敏度】：9.375pg/mL
xy-E10290 【中文名稱】：人c-sis ELISA試劑盒 【英文名稱】：Human c-sis ELISA kit 【靈敏度】：9.375pg/mL
xy-E10291 【中文名稱】：人c-jun ELISA試劑盒 【英文名稱】：Human c-jun ELISA kit 【靈敏度】：9.375pg/mL
xy-E10292 【中文名稱】：人c-fos ELISA試劑盒 【英文名稱】：Human c-fos ELISA kit 【靈敏度】：9.375pg/mL
xy-E10293 【中文名稱】：人c-myc癌基因產(chǎn)物(c-myc)ELISA試劑盒 【英文名稱】：Human c-myc oncogene products (c-myc) ELISA Kit 【靈敏度】：9.375pg/mL
xy-E10294 【中文名稱】：人Smad1 ELISA試劑盒 【英文名稱】：People Smad1 ELISA kit 【靈敏度】：9.375pg/mL
xy-E10295 【中文名稱】：人Smad7 ELISA試劑盒 【英文名稱】：Human Smad7 ELISA Kit 【靈敏度】：9.375pg/mL
xy-E10296 【中文名稱】：人腫瘤相關(guān)抗原(TAA)ELISA試劑盒 【英文名稱】：Human tumor -associated antigens (TAA) ELISA Kit 【靈敏度】：9.375pg/mL
xy-E10297 【中文名稱】：人TGF-β誘導(dǎo)早期基因1(TIEG1)ELISA試劑盒 【英文名稱】：Human TGF-β -induced early gene 1 (TIEG1) ELISA kit 【靈敏度】：9.375pg/mL