激活素受體1A抗體 返回列表頁(yè)

英文名稱 ACTR1
中文名稱 激活素受體1A抗體
別    名 Activin Receptor Type IA; Activin A receptor type I; Activin A receptor type II like kinase 2; Activin receptor type I; Activin receptor type-1; Activin receptor-like kinase 2; ACTR1; ACTR 1; ACTR-1; ACTR-I; ACTRI; ACVR 1; ACVR1; ACVR1_HUMAN; ACVR1A; ACVRLK 2; ACVRLK2; ALK 2; ALK-2; ALK2; FOP; Hydroxyalkyl protein kinase; Serine/threonine protein kinase receptor R1; Serine/threonine-protein kinase receptor R1; SKR 1; SKR1; TGF-B superfamily receptor type I; TGFB superfamily receptor type I; TSR-I; TSRI; TSRI.
激活素受體1A抗體    
說(shuō) 明 書 0.1ml  0.2ml  
研究領(lǐng)域 細(xì)胞生物  信號(hào)轉(zhuǎn)導(dǎo)  生長(zhǎng)因子和激素  轉(zhuǎn)錄調(diào)節(jié)因子  激酶和磷酸酶  細(xì)胞膜受體  跨膜蛋白  細(xì)胞膜蛋白  
抗體來(lái)源 Rabbit
克隆類型 Polyclonal
交叉反應(yīng) Human, Mouse, Rat, Dog, Pig, Cow, Horse, Sheep, 
產(chǎn)品應(yīng)用 WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 Flow-Cyt=1:100-500 ICC=1:100-500 IF=1:100-500 （石蠟切片需做抗原修復(fù)）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 55kDa
細(xì)胞定位 細(xì)胞膜 
性    狀 Lyophilized or Liquid
濃    度 1mg/1ml
免 疫 原 KLH conjugated synthetic peptide derived from human SKR1/ACTR1
亞    型 IgG
純化方法 affinity purified by Protein A
儲(chǔ) 存 液 Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產(chǎn)品介紹 background:
Members of the transforming growth factor b superfamily bind to a pair of transmembrane proteins, known as receptor types I and II, which contain serine/threonine kinases and associate to form a signaling complex (1). Activin has been shown to bind a heteromeric noncovalent complex, which consists of a type I receptor, ACTR-IA (also designated ACVRI and ALK-2) or ACTR-IB (also designated ALK-4 and SKR2), and a type II receptor, ACTR-IIA (also designated ACVR2A) or ACTR-IIB (also designated ACVR2B) (1–6). Both receptor types are highly expressed in brain (5). The activin receptor family members are thought to mediate distinct effects on gene expression, cell differentiation, and morpho- genesis in a dose dependent fashion (5,6).

Function:
On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for activin. May be involved for left-right pattern formation during embryogenesis.

Subunit:
Interacts with FKBP1A. Interacts with FCHO1.

Subcellular Location:
Membrane; Single-pass type I membrane protein.

Tissue Specificity:
Expressed in normal parenchymal cells, endothelial cells, fibroblasts and tumor-derived epithelial cells.

DISEASE:
Defects in ACVR1 are a cause of fibrodysplasia ossificans progressiva (FOP) [MIM:135100]. FOP is a rare autosomal dominant disorder of skeletal malformations and progressive extraskeletal ossification. Heterotopic ossification in FOP begins in childhood and can be induced by trauma or may occur without warning. Bone formation is episodic and progressive, leading to extra-articular ankylosis of all major joints of the axial and appendicular skeleton, rendering movement impossible.

Similarity:
Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family.
TGFB receptor subfamily.
Contains 1 GS domain.
Contains 1 protein kinase domain.

Database links:
UniProtKB/Swiss-Prot: Q04771.1

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.xy-11882R MAGOH增殖相關(guān)蛋白MAGOH抗體
xy-11883R MAP3K4絲裂原活化蛋白激酶激酶激酶4抗體
xy-11884R NEUROD6神經(jīng)細(xì)胞分化因子6抗體
xy-11885R MEIS2同源盒蛋白Meis2抗體
xy-11886R METRNMeteorin神經(jīng)膠質(zhì)細(xì)胞分化調(diào)節(jié)蛋白抗體
xy-11887R MPP5棕櫚?；さ鞍?抗體
xy-11888R MPPED2腦蛋白239抗體
xy-11889R Meis homeobox 3同源盒蛋白MEIS3抗體
xy-11891R Myotrophin顆粒細(xì)胞分化蛋白抗體
xy-11890R Monoamine oxidase A+B單氨氧化酶A+B抗體
xy-12039R MIR16膜蛋白相互作用蛋白R(shí)GS16抗體
xy-8296R Matriptase 2膜型絲氨酸蛋白酶2抗體
xy-7870R MRP8+MRP14多藥耐藥相關(guān)蛋白8/9/14抗體
xy-7914R MOBKL2BMob1同源蛋白MOBKL2B抗體
xy-7915R MOBKL2CMob1同源蛋白MOBKL2C抗體
xy-7880R MEGF5復(fù)合型表皮生長(zhǎng)因子樣結(jié)構(gòu)域蛋白5抗體
xy-9674R MYLIP低密度脂蛋白受體的誘導(dǎo)降解蛋白抗體
xy-9673R ZNF144鋅指蛋白144抗體
xy-6936R MYF5生肌決定因子Myf5抗體
xy-8200R phospho-MYF5 (phospho Ser49)磷酸化生肌決定因子Myf5抗體