精神分裂癥與犰狳重復基因抗體 返回列表頁

英文名稱 ARVCF
中文名稱 精神分裂癥與犰狳重復基因抗體
別    名 Armadillo repeat gene deletes in velocardiofacial syndrome; Armadillo repeat protein; Armadillo repeat protein deleted in velo cardio facial syndrome; Armadillo repeat protein deleted in velo-cardio-facial syndrome; ARVC_HUMAN; Arvcf; FLJ35345; OTTHUMP00000028704; OTTHUMP00000198346; OTTHUMP00000198347; OTTHUMP00000198348.
精神分裂癥與犰狳重復基因抗體
說 明 書 0.2ml  
研究領(lǐng)域 細胞生物  信號轉(zhuǎn)導  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應 Human, Mouse, Rat, Dog, Pig, Horse, Rabbit, 
產(chǎn)品應用 WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蠟切片需做抗原修復）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 105kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/1ml
免 疫 原 KLH conjugated synthetic peptide derived from human ARVCF
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產(chǎn)品介紹 background:
Armadillo Repeat gene deleted in Velo-Cardio-Facial syndrome (ARVCF) is a member of the catenin family. This family plays an important role in the formation of adherens junction complexes, which are thought to facilitate communication between the inside and outside environments of a cell. The ARVCF gene was isolated in the search for the genetic defect responsible for the autosomal dominant Velo-Cardio-Facial syndrome (VCFS), a relatively common human disorder with phenotypic features including cleft palate, conotruncal heart defects and facial dysmorphology. The ARVCF gene encodes a protein containing two motifs, a coiled coil domain in the N-terminus and a 10 armadillo repeat sequence in the midregion. Since these sequences can facilitate protein-protein interactions ARVCF is thought to function in a protein complex. In addition, ARVCF contains a predicted nuclear-targeting sequence suggesting that it may have a function as a nuclear protein. [provided by RefSeq, Jun 2010].

Function:
Involved in protein-protein interactions at adherens junctions.

Subunit:
Interacts (via the extreme C-terminus) with FRMPD2 (via the PDZ 2 domain).

Tissue Specificity:
Found in all the examined tissues including heart, brain, liver and kidney. Found at low level in lung.

Similarity:
Belongs to the beta-catenin family.
Contains 10 ARM repeats.

Gene ID:
421

Database links:

Entrez Gene: 421 Human

Omim: 602269 Human

SwissProt: O00192 Human

Unigene: 699354 Human

Unigene: 713616 Human

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