神經(jīng)細(xì)胞分化相關(guān)蛋白AHNAK抗體 返回列表頁(yè)

英文名稱 AHNAK
中文名稱 神經(jīng)細(xì)胞分化相關(guān)蛋白AHNAK抗體
別    名 AHNAK; AHNAK nucleoprotein (desmoyokin); AHNAKRS; AHNK_HUMAN; Desmoyokin; Fragments; MGC5395; Neuroblast differentiation associated protein AHNAK; Neuroblast differentiation-associated protein AHNAK; PM227.
神經(jīng)細(xì)胞分化相關(guān)蛋白AHNAK抗體    
說(shuō) 明 書 0.1ml  0.2ml  
研究領(lǐng)域 心血管  神經(jīng)生物學(xué)  細(xì)胞分化  
抗體來(lái)源 Rabbit
克隆類型 Polyclonal
交叉反應(yīng) Human, Mouse, Rat, Dog, Pig, Cow, Sheep, 
產(chǎn)品應(yīng)用 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蠟切片需做抗原修復(fù)）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 629kDa
細(xì)胞定位 細(xì)胞核 
性    狀 Lyophilized or Liquid
濃    度 1mg/1ml
免 疫 原 KLH conjugated synthetic peptide derived from human AHNAK
亞    型 IgG
純化方法 affinity purified by Protein A
儲(chǔ) 存 液 Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產(chǎn)品介紹 background:
AHNAK is a 5,890 amino acid protein encoded by the human gene AHNAK. The intronless AHNAK gene is located on human chromosome 11q12 and has three main structural regions: the 251 amino acid N-terminus, a large central region of 4390 amino acids with multiple repeated units of about 128 amino acids in length, and the 1002 amino acid C-terminus. The central region seems to have antiparallel beta-strands connected by intervening loops. Several putative regulatory elements are clustered within the C-terminal region, including nuclear export localization signals, a leucine zipper, and potential phosphorylation sites for Akt1 and PKC. AHNAK is believed to be an important signalling molecule involved in a wide range of physiological activities and may be required for neuronal cell differentiation.. AHNAK also appears to influence b-adrenergic regulation of cardiac L-type Ca2+ channel function.

Function:
May be required for neuronal cell differentiation.

Subunit:
Interacts with DYSF; the interaction is direct and Ca(2+)-independent.

Subcellular Location:
Nucleus.

Similarity:
Contains 1 PDZ (DHR) domain.

Gene ID:
79026

Database links:

Entrez Gene: 79026 Human

Entrez Gene: 66395 Mouse

Entrez Gene: 191572 Rat

Entrez Gene: 718802 Rhesus monkey

Omim: 103390 Human

SwissProt: Q09666 Human

Unigene: 502756 Human

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

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