磷酸化Bcl-xL（Ser62）抗體 返回列表頁

英文名稱 phospho-Bcl-xL (Ser62)
中文名稱 磷酸化Bcl-xL(Ser62)抗體
別    名 BCL2L1 (phospho S62); p-BCL2L1 (phospho S62);Apoptosis regulator Bcl X; BclX; Bcl-X; Bcl 2 like 1; Bcl 2 like 1 protein; Bcl xL; BCL X/L; BCL XL/S; Bcl xS; Bcl2 like1; BCL2-related gene; BCL2-related protein, long isoform, included; BCLXL, included; BCL2-related protein, short isoform, included; BCLXS, included; BCL2L; BCL2L1; Bclx; DKFZp781P2092; MGC113803; MGC99998; B2CL1_HUMAN.
磷酸化Bcl-xL(Ser62)抗體說 明 書 0.1ml  
產(chǎn)品類型 磷酸化抗體 
研究領(lǐng)域 腫瘤  細(xì)胞生物  神經(jīng)生物學(xué)  信號轉(zhuǎn)導(dǎo)  細(xì)胞凋亡  新陳代謝  線粒體  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應(yīng) Human, Mouse, Rat, Dog, Pig, Cow, Horse, Sheep, 
產(chǎn)品應(yīng)用 WB=1:100-500 ELISA=1:500-1000 IP=1:20-100 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蠟切片需做抗原修復(fù)）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 26kDa
細(xì)胞定位 細(xì)胞核 細(xì)胞漿 細(xì)胞膜 線粒體
性    狀 Lyophilized or Liquid
濃    度 1mg/1ml
免 疫 原 KLH conjugated Synthesised phosphopeptide derived from human Bcl-xL around the phosphorylation site of Ser62
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.01M PBS, pH 7.4 with 10 mg/ml BSA and 0.1% Sodium azide
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
磷酸化Bcl-xL(Ser62)抗體產(chǎn)品介紹 background:
The protein encoded by this gene belongs to the BCL-2 protein family. BCL-2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. The proteins encoded by this gene are located at the outer mitochondrial membrane, and have been shown to regulate outer mitochondrial membrane channel (VDAC) opening. VDAC regulates mitochondrial membrane potential, and thus controls the production of reactive oxygen species and release of cytochrome C by mitochondria, both of which are the potent inducers of cell apoptosis. Two alternatively spliced transcript variants, which encode distinct isoforms, have been reported. The longer isoform acts as an apoptotic inhibitor and the shorter form acts as an apoptotic activator. [provided by RefSeq, Jul 2008].

Function:
Potent inhibitor of cell death. Inhibits activation of caspases (By similarity). Appears to regulate cell death by blocking the voltage-dependent anion channnel (VDAC) by binding to it and preventing the release of the caspase activator, CYC1, from the mitochondrial membrane.
Isoform Bcl-X(S) promotes apoptosis.

Subunit:
Homodimer. Isoform Bcl-X(L) forms heterodimers with BAX, BAK or BCL2. Heterodimerization with BAX does not seem to be required for anti-apoptotic activity. Interacts with BCL2L11. Interacts with DMN1L; the interaction stimulates the GTPase activity of DMN1L in synapses and increases the number of axonal mitochondria and the size and number of synaptic vesicle clusters. Interacts with BAD and BBC3. Interacts (isoform Bcl-X(L)) with SIVA1 (isoform 1); the interaction inhibits the anti-apoptotic activity. Interacts with BECN1 and PGAM5. Interacts (isoform Bcl-X(L)) with BAX (isoform Sigma). Isoform Bcl-X(L) interacts with IKZF3. Interacts with HEBP2.

Subcellular Location:
Mitochondrion membrane; Single-pass membrane protein. Nucleus membrane; Single-pass membrane protein; Cytoplasmic side. Cytoplasm, cytoskeleton, centrosome. Note=Mitochondrial membranes and perinuclear envelope. Localizes to the centrosome when phosphorylated at Ser-49.

Tissue Specificity:
Bcl-X(S) is expressed at high levels in cells that undergo a high rate of turnover, such as developing lymphocytes. In contrast, Bcl-X(L) is found in tissues containing long-lived postmitotic cells, such as adult brain.

Post-translational modifications:
Proteolytically cleaved by caspases during apoptosis. The cleaved protein, lacking the BH4 motif, has pro-apoptotic activity.
Phosphorylated on Ser-62 by CDK1. This phosphorylation is partial in normal mitotic cells, but complete in G2-arrested cells upon DNA-damage, thus promoting subsequent apoptosis probably by triggering caspases-mediated proteolysis. Phosphorylated by PLK3, leading to regulate the G2 checkpoint and progression to cytokinesis during mitosis. Phosphorylation at Ser-49 appears during the S phase and G2, disappears rapidly in early mitosis during prometaphase, metaphase and early anaphase, and re-appears during ophase and cytokinesis.

Similarity:
Belongs to the Bcl-2 family.

Gene ID:
598

Database links:

Entrez Gene: 598 Human

Entrez Gene: 12048 Mouse

Entrez Gene: 24888 Rat磷酸化Bcl-xL(Ser62)抗體xy-0917R BrdU溴脫氧尿苷抗體
xy-9114R BAGE2腫瘤/睪丸抗原2.2抗體
xy-9115R BAGE3腫瘤/睪丸抗原2.3抗體
xy-9116R BAGE4腫瘤/睪丸抗原2.4抗體
xy-0044R BNP腦鈉素/利鈉肽抗體
xy-1089R B-RafB Raf抗體
xy-0802R BRCA1乳腺癌易感基因1抗體
xy-1210R FANCB乳腺癌易感基因2抗體
xy-0489R BrdU溴脫氧尿苷抗體
xy-0031R BTG2B細(xì)胞遷移基因2抗體
xy-1012R BMP2骨形態(tài)發(fā)生蛋白2抗體
xy-2242R BMP7骨形態(tài)發(fā)生蛋白7抗體
xy-1090R Beta cateninβ-連環(huán)蛋白/β-連環(huán)素/β鏈接素抗體
xy-1165R Beta cateninβ-連環(huán)蛋白/β-連環(huán)素/β鏈接素抗體
xy-7679R BCCIP乳腺癌易感基因2和p21蛋白抑制因子抗體
xy-7589R Blood Group Antigen Precursor血型抗原前體蛋白抗體
xy-7590R CD238凱爾血型糖蛋白CD238抗體
xy-7700R BTN2A2嗜乳脂蛋白亞家族2成員A2抗體
xy-9447R BMP10骨形態(tài)發(fā)生蛋白10抗體
xym-0917M BrdU (A7)溴脫氧尿苷單克隆抗體（增殖標(biāo)志物）
xy-9551R BEND2BEND2蛋白抗體
xy-4729R Bone Sialoprotein骨涎蛋白
xy-8876R Vibrio Parahemolyticus Polar flagellin B/D副溶血性弧菌菌體鞭毛蛋白抗體
xy-8159R BTBD6BTBD6蛋白抗體
xy-6910R BMPERBMP內(nèi)皮細(xì)胞調(diào)節(jié)蛋白抗體
xy-8158R HCV NS5A transactivated protein 8丙肝病毒NS5A反轉(zhuǎn)錄蛋白8抗體
xy-6401R BMP1骨形態(tài)發(fā)生蛋白1/膠原C蛋白肽鏈內(nèi)切酶抗體
xy-6909R BMP9骨形態(tài)發(fā)生蛋白9抗體
xy-7849R Beta tubulin cofactor D微管蛋白β輔助因子D抗體

Omim: 600039 Human

SwissProt: Q07817 Human

SwissProt: Q64373 Mouse

SwissProt: P53563 Rat

Unigene: 516966 Human

Unigene: 238213 Mouse

Unigene: 10323 Rat

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.