β葡聚糖受體抗體 返回列表頁(yè)

英文名稱 beta Glucan Receptor
中文名稱 β葡聚糖受體抗體
別    名 Dectin1; Dectin-1; Dectin 1; CLECSF12; C-type lectin domain family 7 member A; beta Glucan Receptor; Beta GR; BGR; C type calcium dependent carbohydrate recognition domain lectin superfamily member 12; Clec7a; CANDF4; DECTIN1; CLEC7A protein; Clecsf12; Dectin 1; DECTIN 1 receptor; Dectin1; Dendritic cell associated C type lectin 1; Lectin like receptor 1; beta Glucan Receptor; Putative transmembrane protein dectin 1; CLC7A_HUMAN.
 β葡聚糖受體抗體
 
說(shuō) 明 書(shū) 0.1ml  0.2ml  
研究領(lǐng)域 細(xì)胞生物  免疫學(xué)  淋巴細(xì)胞  
抗體來(lái)源 Rabbit
克隆類型 Polyclonal
交叉反應(yīng) Human, Mouse, Rat, 
產(chǎn)品應(yīng)用 WB=1:100-500 ELISA=1:500-1000 IP=1:20-100 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蠟切片需做抗原修復(fù)）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 28kDa
細(xì)胞定位 細(xì)胞膜 
性    狀 Lyophilized or Liquid
濃    度 1mg/1ml
免 疫 原 KLH conjugated synthetic peptide derived from human Dectin-1
亞    型 IgG
純化方法 affinity purified by Protein A
儲(chǔ) 存 液 0.01M PBS, pH 7.4 with 10 mg/ml BSA and 0.1% Sodium azide
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
 β葡聚糖受體抗體
產(chǎn)品介紹 background:
This gene encodes a member of the C-type lectin/C-type lectin-like domain (CTL/CTLD) superfamily. The encoded glycoprotein is a small type II membrane receptor with an extracellular C-type lectin-like domain fold and a cytoplasmic domain with an immunoreceptor tyrosine-based activation motif. It functions as a pattern-recognition receptor that recognizes a variety of beta-1,3-linked and beta-1,6-linked glucans from fungi and plants, and in this way plays a role in innate immune response. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. This gene is closely linked to other CTL/CTLD superfamily members on chromosome 12p13 in the natural killer gene complex region. [provided by RefSeq].

Function:
Lectin that functions as pattern receptor specific for beta-1,3-linked and beta-1,6-linked glucans, such as cell wall constituents from pathogenic bacteria and fungi. Necessary for the TLR2-mediated inflammatory response and for TLR2-mediated activation of NF-kappa-B. Enhances cytokine production in macrophages and dendritic cells. Mediates production of reactive oxygen species in the cell. Mediates phagocytosis of C.albicans conidia. Binds T-cells in a way that does not involve their surface glycans and plays a role in T-cell activation. Stimulates T-cell proliferation (By similarity).

Subunit:
Homodimer. Interacts with SYK; participates in leukocyte activation in presence of fungal pathogens.

Subcellular Location:
Cell membrane; Single-pass type II membrane protein.

Tissue Specificity:
Detected in dendritic cells, in paracortical and medullary regions of lymph nodes, and in spleen red pulp and white pulp.

Post-translational modifications:
on tyrosine residues in response to glucan binding.

Similarity:
Contains 1 C-type lectin domain.

Gene ID:
64581

Database links:

Entrez Gene: 64581 Human

Entrez Gene: 56644 Mouse

Entrez Gene: 502902 Rat

Omim: 606264 Human

SwissProt: Q9BXN2 Human

SwissProt: Q6QLQ4 Mouse

Unigene: 143929 Human

Unigene: 239516 Mouse

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
 β葡聚糖受體抗體
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