長鏈脂肪酸?；o酶A水解酶抗體 返回列表頁

英文名稱 BAAT
中文名稱 長鏈脂肪酸?；o酶A水解酶抗體
別    名 BACAT; BAT; Bile acid CoA:amino acid N acyltransferase; Bile acid Coenzyme A amino acid N acyltransferase glycine N choloyltransferase ; Bile acid Coenzyme A: amino acid N acyltransferase; Glycine N choloyltransferase; Long chain fatty acyl CoA hydrolase; MGC104432; FLJ20300; BAAT; BAAT_HUMAN; Bile acid CoA: amino acid N-acyltransferase (glycine N-choloyltransferase); Bile acid Coenzyme A amino acid N acyltransferase glycine N choloyltransferase.
 長鏈脂肪酸?；o酶A水解酶抗體   
說 明 書 0.2ml  
研究領(lǐng)域 腫瘤  細(xì)胞生物  免疫學(xué)  轉(zhuǎn)錄調(diào)節(jié)因子  轉(zhuǎn)運蛋白  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應(yīng) Human, Mouse, Rat, Horse, Rabbit, 
產(chǎn)品應(yīng)用 WB=1:100-500 ELISA=1:500-1000 IP=1:20-100 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蠟切片需做抗原修復(fù)）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 46kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/1ml
免 疫 原 KLH conjugated synthetic peptide derived from human BAAT
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.01M PBS, pH 7.4 with 10 mg/ml BSA and 0.1% Sodium azide
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
 產(chǎn)品介紹 background:
BAAT (bile acid Coenzyme A: amino acid N-acyltransferase) is involved in bile acid metabolism. In liver hepatocytes BAAT catalyzes the transfer of the bile acid moiety from the acyl-CoA thioester to glycine and taurine, before excretion into bile canaliculi. This is the second step in the formation of bile acid-amino acid conjugates. The conjugation increases the detergent properties of bile acids in the intestine, which facilitates lipid and fat-soluble vitamin absorption. BAAT may also act as an acyl-CoA thioesterase that regulates intracellular levels of free fatty acids.

Function:
Involved in bile acid metabolism. In liver hepatocytes catalyzes the second step in the conjugation of C24 bile acids (choloneates) to glycine and taurine before excretion into bile canaliculi. The major components of bile are cholic acid and chenodeoxycholic acid. In a first step the bile acids are converted to an acyl-CoA thioester, either in peroxisomes (primary bile acids deriving from the cholesterol pathway), or cytoplasmic at the endoplasmic reticulum (secondary bile acids). May catalyze the conjugation of primary or secondary bile acids, or both. The conjugation increases the detergent properties of bile acids in the intestine, which facilitates lipid and fat-soluble vitamin absorption. In turn, bile acids are deconjugated by bacteria in the intestine and are recycled back to the liver for reconjugation (secondary bile acids). May also act as an acyl-CoA thioesterase that regulates intracellular levels of free fatty acids. In vitro, catalyzes the hydrolysis of long- and very long-chain saturated acyl-CoAs to the free fatty acid and coenzyme A (CoASH), and conjugates glycine to these acyl-CoAs.

Subcellular Location:
Cytoplasm.

Tissue Specificity:
Expressed in liver, gallbladder mucosa and pancreas.

DISEASE:
Defects in BAAT are involved in familial hypercholanemia (FHCA) [MIM:607748]. FHCA is a disorder characterized by elevated serum bile acid concentrations, itching, and fat malabsorption.

Similarity:
Belongs to the C/M/P thioester hydrolase family.

Database links:

Entrez Gene: 570 Human

Entrez Gene: 12012 Mouse

Entrez Gene: 29725 Rat

Omim: 602938 Human

SwissProt: Q14032 Human

SwissProt: Q91X34 Mouse

SwissProt: Q63276 Rat

Unigene: 284712 Human

Unigene: 2859 Mouse

Unigene: 11129 Rat

Important Note:
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