AU RNA Binding Protein/enoyl-CoA Hydratase (AUH) (C-Term) 抗體

抗原
AU RNA Binding Protein/enoyl-CoA Hydratase (AUH)
別名 5033405N08Rik, wu:fb81b10, zgc:101057, C77140, W91705
抗原表位
 其他選擇C-Term
適用
 其他選擇Murine, Rat ((Rattus)), Dog (Canine), Human, Chicken
宿主
 其他選擇Rabbit
克隆類型
多克隆
應(yīng)用范圍
 其他選擇Immunohistochemistry (IHC), Western Blotting (WB)
[Pubmed] 1 reference available
規(guī)格 50 μg
發(fā)貨至 中國(guó) (更改)
發(fā)貨時(shí)間 9至12個(gè)工作日

AU RNA Binding Protein/enoyl-CoA Hydratase (AUH) (C-Term) 抗體

產(chǎn)品細(xì)節(jié)

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免疫原 Synthetic peptide directed towards the C terminal of human AUH
序列 IGMSLAKELI FSARVLDGKE AKAVGLISHV LEQNQEGDAA YRKALDLARE
預(yù)測(cè)反應(yīng) Bovine : 100 %, Human : 100 %, Mouse : 100 %, Pig : 100 %, Rabbit : 100 %, Rat : 100 %, Guinea pig : 90 %, Chicken : 70 %
產(chǎn)品特性 This is a rabbit polyclonal antibody against AUH. It was validated on Western Blot and immunohistochemistry.
純化方法 Affinity Purified

AU RNA Binding Protein/enoyl-CoA Hydratase (AUH) (C-Term) 抗體目標(biāo)詳細(xì)情況

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別名 AUH
背景 AU-specific RNA-binding enoyl-CoA hydratase (AUH) protein binds to the AU-rich element (ARE), a common element found in the 3' UTR of rapidly decaying mRNA such as c-fos, c-myc and granulocyte/ macrophage colony stimulating factor. ARE elements are involved in directing RNA to rapid degradation and deadenylation. AUH is also homologous to enol-CoA hydratase, an enzyme involved in fatty acid degradation, and has been shown to have intrinsic hydratase enzymatic activity. AUH is thus a bifunctional chimera between RNA binding and metabolic enzyme activity. A possible subcellular localization in the mitochondria has been demonstrated for the mouse homolog of this protein which shares 92 % identity with the human protein. It has been suggested that AUH may have a novel role as a mitochondrial located AU-binding protein. Human AUH is expressed as a single mRNA species of 1.8 kb, and translated as a 40-kDa precursor protein which is subsequently processed to a 32-kDa mature form.AU-specific RNA-binding enoyl-CoA hydratase (AUH) protein binds to the AU-rich element (ARE), a common element found in the 3' UTR of rapidly decaying mRNA such as c-fos, c-myc and granulocyte/ macrophage colony stimulating factor. ARE elements are involved in directing RNA to rapid degradation and deadenylation. AUH is also homologous to enol-CoA hydratase, an enzyme involved in fatty acid degradation, and has been shown to have intrinsic hydratase enzymatic activity. AUH is thus a bifunctional chimera between RNA binding and metabolic enzyme activity. A possible subcellular localization in the mitochondria has been demonstrated for the mouse homolog of this protein which shares 92 % identity with the human protein. It has been suggested that AUH may have a novel role as a mitochondrial located AU-binding protein. Human AUH is expressed as a single mRNA species of 1.8 kb, and translated as a 40-kDa precursor protein which is subsequently processed to a 32-kDa mature form.
分子量 37 kDa
基因ID 549
NCBI Accession NP_001689, NM_001698
UniProt Q13825
研究領(lǐng)域 Chromatin and Nuclear Signaling, Chromatin Binding Proteins, Metabolism, Organelles

AU RNA Binding Protein/enoyl-CoA Hydratase (AUH) (C-Term) 抗體使用細(xì)節(jié)

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應(yīng)用備注 Optimal working dilutions should be determined experimentally by the investigator.
說(shuō)明

Antigen size: 339 AA

限制 For Research Use only

貯存及處理

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狀態(tài) Lyophilized
溶解方式 Add 50 µL of distilled water.
濃度 1 mg/mL
緩沖液 PBS buffer with 2 % sucrose
注意事項(xiàng) Avoid repeated freeze-thaw cycles.
儲(chǔ)存條件 -20 °C
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