MC3R抗體 返回列表頁

MC3R抗體

抗原
Melanocortin 3 Receptor (MC3R)
別名 zgc:194235, MC3-R, BMIQ9, MC3, OB20, OQTL
適用
其他選擇 Human, Murine, Rat ((Rattus))
Human(23),Murine (3),Rat ((Rattus)) (3),Chimpanzee (1)
宿主
其他選擇 Rabbit
Rabbit(19),Goat (5),Mouse (1)
克隆類型
多克隆
標記
其他選擇 非結(jié)合性
APC(1),Alkaline Phosphatase (AP) (1),Biotin (1),FITC (1),HRP (1),PE (1)
應(yīng)用范圍
其他選擇 Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunoprecipitation (IP), Western Blotting (WB)
Western Blotting (WB)(23),ELISA (15),Flow Cytometry (FACS) (4),Immunohistochemistry (Frozen Sections) (IHC (fro)) (2),Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) (2),Immunoprecipitation (IP) (2),Enzyme Immunoassay (EIA) (1),Immunohistochemistry (IHC) (1)
[Pubmed] 4 references available
規(guī)格 0.1 mg
發(fā)貨至 中國 (更改)
發(fā)貨時間 29至35個工作日

MC3R抗體

產(chǎn)品細節(jié)

引用 貯存及處理 使用細節(jié) 目標詳細情況 回頁首

產(chǎn)品細節(jié)

顯示 隱藏
免疫原 Synthetic peptide from mid region of MC3R protein
特異性 This antibody detects a diffuse band at 55?kDa of MC3R. It does not cross react with any other MC receptors.
交叉反應(yīng) （詳細） Species reactivity (tested):Human, mouse, rat
純化方法 Affinity chromatography

目標詳細情況

引用 貯存及處理 使用細節(jié) 回頁首

目標詳細情況

顯示 隱藏
別名 MC3-R
背景 The Proopiomelanocortin (POMC) is expressed in the arcuate nucleus of the hypothalamus (ARC) and the commissural nucleus of the solitary tract (cNTS) is post-translational processed to produce two melanocortin receptor ligands, alpha- and gamma-melanocyte-stimulating hormone (MSH). These endogenous peptides have long been reported topossess anti-inflammatory effects in many experimental modelsof acute and chronic inflammation, including experimental boweldisease, allergy, and chronic (mycobacterium-induced arthritis)and systemic inflammation (endotoxemia) (1). Melanocortins are ligands for a subgroup of GPCRs positively coupled to Adenylate cylcases, termed as melanocortin receptor (MC1-R, MC2R, MC3R, MC4R amd MC5R). These receptors are widely expressed at varied density throughoutthe body. Specific physioological actions have been implecated to specific MC recpetors such as skin pigmentation to MC1C, stimulation of adrenal steriodogenesis to MC2R, obesity ralted effects to MC4R and anti-inflammatory effects to MC3R (2) Two melanocortin receptors (MC3R, MC4R) are expressed in brain regions receiving projections of POMC fibers, most of which also receive projections from a population of arcuate neurons that co-express neuropeptide Y (NPY) and the MC3R/MC4R antagonist agouti-related peptide (AgRP). Recent dta suggest that MC3R knock out mice exhibit reduced linear growth and lean mass and are hyperleptinemic and hyperinsulinemic. The MC3R knock out mice did not show type 2 diabetes contract to a common finding in MC4R knock out mice (3).Synonyms: MC3R, Melanocortin receptor 3
基因ID 4159
NCBI Accession NP_063941
UniProt P41968

使用細節(jié)

引用 貯存及處理 目標詳細情況 回頁首

使用細節(jié)

顯示 隱藏
應(yīng)用備注 Immunohistochemistry on frozen sections. Immunoprecipitation. Western blot: > 1: 500.
限制 For Research Use only

貯存及處理

引用 使用細節(jié) 目標詳細情況 回頁首

貯存及處理

顯示 隱藏
濃度 0.5 - 0.6 mg/mL
緩沖液 Stabilization buffer with 0.02?% sodium azide as preservative
儲存液 Sodium azide
注意事項 This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
注意事項 Avoid repeated freezing and thawing.
儲存條件 4 °C/-20 °C
儲存方法 Store at 2 - 8 °C for up to one month or (in aliquots) at -20 °C.

xy-3099R Phospho-Cofilin (Ser3)磷酸化絲切蛋白抗體
xy-2760R Cortactin皮層肌動蛋白抗體
xy-2792R CRHR2促腎上腺皮質(zhì)釋放激素受體2抗體
xy-3241R Phospho-c-Kit(Tyr703)磷酸化原癌基因c-kit抗體
xy-3242R Phospho-c-Kit(Tyr721)磷酸化原癌基因c-kit抗體
xy-2727R CRLF2胸腺基質(zhì)淋巴細胞生成素受體抗體
xy-4083R phospho-c-Abl (Tyr134)磷酸化非受體酪氨酸激酶c-Abl抗體
xy-4084R phospho-c-Abl (Tyr253)磷酸化非受體酪氨酸激酶c-Abl抗體
xy-5149R CPI17 alpha蛋白磷酸激酶PKC/CPI-17抗體
xy-4085R phospho-c-Abl(Tyr272)磷酸化非受體酪氨酸激酶c-Abl抗體
xy-4086R phospho-c-Abl(Tyr276)磷酸化非受體酪氨酸激酶c-Abl抗體
xy-10088R CLPS胰輔脂酶抗體
xy-9681R C19orf4519號染色體開放閱讀框45抗體
xy-9692R C20orf111過氧化氫誘導(dǎo)轉(zhuǎn)錄蛋白1抗體
xy-6202R CIKS核因子NFκB激活蛋白1抗體
xy-6987R C12orf23第12號染色體開放閱讀框23抗體
xy-6990R γ-Cateninγ-連環(huán)素/連接蛋白γ抗體
xy-9767R C10orf410號染色體開放閱讀框4抗體
xy-9768R C10orf4710號染色體開放閱讀框47抗體
xy-9770R C10orf8110號染色體開放閱讀框81抗體
xy-9683R C19orf4719號染色體開放閱讀框47抗體
xy-9684R C19orf5419號染色體開放閱讀框54抗體
xy-9685R C1GALT1N-乙酰半乳糖胺糖蛋白3、β-半乳糖轉(zhuǎn)移酶1抗體
xy-9677R C19orf1819號染色體開放閱讀框18抗體
xy-9678R C19orf2119號染色體開放閱讀框21抗體
xy-9679R C19orf2419號染色體開放閱讀框24抗體
xy-4851R Collagen alpha-1(II) chain Ⅱ型膠原α1蛋白/軟骨鈣素抗體