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TLR7抗體

抗原
Toll-Like Receptor 7 (TLR7)
別名 TLR7A, TLR7-like, RGD1563357
抗原表位
其他選擇 N-Term, AA 714-736
C-Term(15),AA 451-500 (11),Middle Region (8),N-Term (8),Internal Region (7),AA 27-126 (6),AA 706-728 (6),AA 898-927 (5),AA 465-483 (4),AA 650-700 (4),AA 360-516 (3),AA 900-950 (3),AA 562-839 (2),AA 750-800 (2),AA 899-926 (2),AA 98-128 (2),Extracellular Domain (2),AA 1-1049 (1),AA 274-377 (1),AA 415-513 (1),AA 421-660 (1),AA 871-1020 (1),AA 887-1036 (1),AA 890-1037 (1),Internal Domain (1)
適用
其他選擇 Cat, Human, Murine, Pig (Porcine)
Human(131),Murine (62),Rat ((Rattus)) (25),Dog (Canine) (15),Bovine (14),Pig (Porcine) (13),Cat (1),Horse (Equine) (1),Mammalian (1),Monkey (1)
宿主
其他選擇 Rabbit
Rabbit(109),Mouse (33),Chicken (3),Goat (1)
克隆類型
多克隆
標(biāo)記
其他選擇 非結(jié)合性
Biotin(6),FITC (5),HRP (5),APC (3),Alkaline Phosphatase (AP) (3),PE (3),Alexa Fluor 350 (1),Alexa Fluor 488 (1),Alexa Fluor 555 (1),Alexa Fluor 647 (1),CF (1),Cy3 (1),Cy5 (1),Cy5.5 (1),Cy7 (1)
應(yīng)用范圍
其他選擇 Dot Blot (DB), Enzyme Immunoassay (EIA), Western Blotting (WB)
Western Blotting (WB)(107),ELISA (48),Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) (28),Flow Cytometry (FACS) (21),Immunohistochemistry (IHC) (20),Immunocytochemistry (ICC) (13),Immunohistochemistry (Frozen Sections) (IHC (fro)) (13),Immunofluorescence (Paraffin-embedded Sections) (IF (p)) (10),Immunofluorescence (IF) (7),Enzyme Immunoassay (EIA) (5),Immunohistochemistry (Frozen Paraffin-embedded Sections) (IHC (frpe)) (5),Immunohistochemistry (Formalin-fixed Sections) (IHC (f)) (1),Immunoprecipitation (IP) (1)
[Pubmed] 5 references available
規(guī)格 0.1 mg
發(fā)貨至 中國 (更改)
發(fā)貨時(shí)間 29至35個(gè)工作日

TLR7抗體

產(chǎn)品細(xì)節(jié)

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產(chǎn)品細(xì)節(jié)

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免疫原 Synthetic peptide selected from Human TLR7 corresponding to amino acids 714-736 form the amino terminal end of the protien (aa: lsh nql ttv per lsn csr slk nl)
亞型 IgG
特異性 The antibody labels a band of around 101?kDa in Western blot positive control samples for TLR5 and several other tissues.
純化方法 Affinity Chromatography using immobilized antigen

目標(biāo)詳細(xì)情況

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別名 TLR7
背景 The mammalian host defense system is essentially regulated by highly conserved Toll-like receptor (TLR) family of proteins. At least 13 TLRs have been identified and cloned in mammalian cells which recognize molecular products/signals from all the major classes of pathogens and activation of innate immunity. The Toll signaling to NF-Kb starts form conserved Toll-IL-1-resistance (TIR) domain, which mediated the coupling of TIR adaptor molecules (MyD88, Mal, TICAM and TRAM) and caused production of inflammatory cytokines such as IL-1, IL-6, IL-8 , TNFa, and IL-12, chemokines and co-stimulatory molecules such as CD40, CD80 and CD86. In the presence of inflammatory cytokines and binding of adaptor molecule, MyD88 that binds FADD and triggers apoptosis through the caspase cascade. TLR induced apoptosis pathway appears to be a repertoire of defense mechanism utilized by innate defense mechanism. The constitutive expression of many human TLRs (1, 2, 3) have been shown on the surface of myeloid lineage cells by RT-PCR and use of specific monoclonal antibodies. Upon activation of these receptors by their respective chemokines and ligands have been shown in literature on various cell lines including endothelial, epithelial and other cells. The expression of TLR 3, 7, 8 and 9 are mainly found on endosomal lysosomal compartments. Human TLR3 is expressed in human fibroblasts cells and TLR 9 in in-vitro derived DC cells. There is significant evidence of TLR involvement is many systemic disorders following bacterial infection including sepsis, peridontitis, cardiac ischemia, cerebral palsy and others, understanding the TLRs involvement in these conditions will allow therapeutic interventions at the receptor level for treatment of these disorders. The TLR are highly conserved protein and share structural and functional domains across species. These receptors recognize pathogen associated molecular patters (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines needed for production of immediate immunity. The cell-surface TLRs, including TLR1, TLR2, TLR4, and TLR6, recognize microbial membrane lipids, whereas TLR3, TLR7, TLR8, and TLR9 recognize pathogen-derived nucleotides in intracellular compartments. TLR7 and TLR9 respond to host-derived nucleotides as well, and they have been implicated in a variety of autoimmune diseases. TLR2 and TLR5 mRNA was detected in the CD8(+) T cells from cord blood. The expression of TLR4 and TLR5 are reduced in asthmatic patients which may be partly responsible for immunopathological mechanism of asthma by reducing the release of Th1 anti-inflammatory cytokines (4). TLR7 is a membrane bound protein with two TMD. The first human toll like receptor to be identified, TLR4, senses lipopolysaccharide (LPS) while TLR2 on the other hand senses diacylated or triacylated lipopeptides after heterodimerizing with either TLR6 or TLR1, respectively. The conserved cytoplasmic TIR (Toll/IL-1 receptor) domains of the IL-1 and Toll-like receptors are the critical focal point for the generation of ligand-induced cytoplasmic signaling cascades. For signaling all the TLRs utilize one or more of the four known TIR-containing adaptor molecules: MyD88, TIRAP/MAL, TRIF, and TRAM. Human TLR2 is a 839 amino acid (105 kDa) type I trans-membrane receptor protein characterized by extracellular domains with leucine-rich repeats and a cytoplasmic domain with type I IL-1 receptor. The TLR 2 and 4 are pattern recognition receptors and signaling molecules in response to bacterial lipoproteins and is involved in innate immunity. TLR4 is expressed on peripheral blood and together with MD-2 and CD14 is responsible for LPS signaling recognition. Many specific adapter molecules (TICAM, MyD88, ICAM2, TRAM, TIRAP, TRIF) are involved in signaling of several other TLRs.Synonyms: Toll-like receptor 7
基因ID 51284
NCBI Accession NP_057646
UniProt Q9NYK1
研究領(lǐng)域 Immunology, Innate Immunity, Transcription Factors, Signaling, Inflammation

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使用細(xì)節(jié)

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應(yīng)用備注 ELISA/Dot blot: 1/20,000. Western Blot: 1/500.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
限制 For Research Use only

貯存及處理

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貯存及處理

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濃度 0.78-0.80 mg/mL
緩沖液 Stabilization buffer
注意事項(xiàng) Avoid repeated freezing and thawing.
儲(chǔ)存條件 -20 °C
儲(chǔ)存方法 Store the antibody undiluted (in aliquots) at-20 °C.

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