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NOTCH1 抗體

抗原
Notch 1 (NOTCH1)
別名 notch1, NOTCH1, hn1, tan1, notch, xotch, xnotch, notch-1, xnotch1, TAN1, hN1, 9930111A19Rik, Mis6, N1, Tan1, lin-12, NOTCH, Xotch, notch1-a
抗原表位
其他選擇 Middle Region
N-Term(30),AA 20-216 (19),C-Term (17),Internal Region (7),AA 2488-2502 (6),AA 19-526 (5),Cleaved-Val1754 (5),AA 2300-2556 (4),AA 1299-1492 (3),AA 2428-2556 (3),Cleaved-Val1744 (3),Middle Region (3),Val1754 (3),AA 1755-1767 (2),AA 2505-2555 (2),Intracellular (2),AA 1601-1619 (1),AA 1721-1815 (1),AA 1735-1784 (1),AA 1754-2556 (1),AA 1955-2177 (1),AA 2272-2488 (1),AA 23-132 (1),AA 2400-2450 (1),AA 2542-2554 (1),AA 381-853 (1),Cleaved-Val744 (1),Val2562 (1)
適用
其他選擇 Rat ((Rattus)), Murine, Zebrafish (Danio rerio), Xenopus laevis, Human, Chicken
Human(128),Murine (105),Rat ((Rattus)) (31),Zebrafish (4),Mammalian (2),Chicken (1),Xenopus laevis (1),Zebrafish (Brachydanio rerio) (1)
宿主
其他選擇 Rabbit
Rabbit(94),Mouse (82),Armenian Hamster (11),Hamster (4),Sheep (4),Goat (3),Rat (2)
克隆類型
多克隆
標(biāo)記
其他選擇 非結(jié)合性
PE(15),Biotin (11),APC (5),FITC (4),Alkaline Phosphatase (AP) (2),PerCP (2),Atto 390 (1),Atto 488 (1),Atto 565 (1),Atto 594 (1),Atto 633 (1),Atto 655 (1),Atto 680 (1),Atto 700 (1),DyLight 488 (1),DyLight 550 (1),DyLight 594 (1),DyLight 650 (1),DyLight 755 (1),HRP (1),Magnetic Particles (1),PE-Atto 594 (1),Sepharose (1),Streptavidin (1)
應(yīng)用范圍
其他選擇 Western Blotting (WB)
Western Blotting (WB)(116),Flow Cytometry (FACS) (65),ELISA (47),Immunohistochemistry (IHC) (43),Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) (37),Immunocytochemistry (ICC) (28),Immunohistochemistry (Frozen Sections) (IHC (fro)) (13),Immunoprecipitation (IP) (10),Immunofluorescence (IF) (9),Immunohistochemistry (Frozen Paraffin-embedded Sections) (IHC (frpe)) (6),Enzyme Immunoassay (EIA) (3),Immunostaining (IS) (2),Chromatin Immunoprecipitation (ChIP) (1),Proximity Ligation Assay (PLA) (1),Reverse Phase Protein Array (RPPA) (1)
[Pubmed] 1 reference available
規(guī)格 50 μg
發(fā)貨至 中國 (更改)
發(fā)貨時(shí)間 9至12個(gè)工作日

NOTCH1 抗體

產(chǎn)品細(xì)節(jié)

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產(chǎn)品細(xì)節(jié)

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免疫原 Synthetic peptide directed towards the middle region of human NOTCH1
序列 EHPFLTPSPE SPDQWSSSSP HSNVSDWSEG VSSPPTSMQS QIARIPEAFK
預(yù)測反應(yīng) Chicken : 92 %, Guinea pig : 92 %, Horse : 92 %, Zebrafish : 92 %, Rat : 82 %, Bovine : 72 %, Dog : 72 %, Mouse : 72 %
產(chǎn)品特性 This is a rabbit polyclonal antibody against NOTCH1. It was validated on Western Blot using a cell lysate as a positive control.
純化方法 Affinity Purified

目標(biāo)詳細(xì)情況

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目標(biāo)詳細(xì)情況

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別名 NOTCH1
背景 NOTCH1 is a member of the Notch family. Notch family members play a role in a variety of developmental processes by controlling cell fate decisions. The Notch signaling network is an evolutionarily conserved intercellular signaling pathway which regulates interactions between physically adjacent cells. This protein is cleaved in the trans-Golgi network, and presented on the cell surface as a heterodimer. This protein functions as a receptor for membrane bound ligands, and may play multiple roles during development.This gene encodes a member of the Notch family. Members of this Type 1 transmembrane protein family share structural characteristics including an extracellular domain consisting of multiple epidermal growth factor-like (EGF) repeats, and an intracellular domain consisting of multiple, different domain types. Notch family members play a role in a variety of developmental processes by controlling cell fate decisions. The Notch signaling network is an evolutionarily conserved intercellular signaling pathway which regulates interactions between physically adjacent cells. In Drosophilia, notch interaction with its cell-bound ligands (delta, serrate) establishes an intercellular signaling pathway that plays a key role in development. Homologues of the notch-ligands have also been identified in human, but precise interactions between these ligands and the human notch homologues remain to be determined. This protein is cleaved in the trans-Golgi network, and presented on the cell surface as a heterodimer. This protein functions as a receptor for membrane bound ligands, and may play multiple roles during development.
分子量 88 kDa
基因ID 4851
NCBI Accession NM_017617, NP_060087
UniProt P46531
研究領(lǐng)域 Receptors, Signaling, Inflammation, Immunology

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應(yīng)用備注 Optimal working dilutions should be determined experimentally by the investigator.
說明

Antigen size: 2555 AA

限制 For Research Use only

貯存及處理

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狀態(tài) Lyophilized
溶解方式 Add 50 µL of distilled water.
濃度 1 mg/mL
緩沖液 PBS buffer with 2 % sucrose
注意事項(xiàng) Avoid repeated freeze-thaw cycles.
儲(chǔ)存條件 -20 °C
儲(chǔ)存方法 For longer periods of storage, store at -20 °Cxy-3238R Phospho-Jak1 (Tyr1022 + Tyr1023)磷酸化蛋白質(zhì)酪氨酸激酶JAK-1抗體
xy-2900R JNK2氨基末端激酶2抗體
xy-7614R JMY連接介導(dǎo)調(diào)節(jié)蛋白抗體
xy-2997R JNK3氨基末端激酶3抗體
xy-11228R Phospho-JunB (Thr102 + Thr104)磷酸化活化蛋白激酶B抗體
xy-13601R JHD1JmjC結(jié)構(gòu)域組蛋白去甲基化酶H3-K36抗體
xy-11860R Jarid2組蛋白去甲基化酶JARID2抗體
xy-6814R JAKMIP2JAK和微管相互作用蛋白2抗體（JAK和微管相互作用蛋白2）
xy-1836R JunB活化蛋白激酶B抗體
xy-2485R phospho-JAK2(Tyr1007+Tyr1008)磷酸化蛋白酪氨酸激酶JAK-2抗體
xy-6842R JMJD6凋亡細(xì)胞清除受體抗體
xy-4601R phospho-c-Jun(Thr91+Thr93)磷酸化原癌基因c-Jun抗體
xy-4244R Jagged 2Notch配體Jagged 2蛋白抗體
xy-8178R Jarid1C組蛋白去甲基化Jarid1C抗體
xy-3824R JMJD1B組蛋白去甲基轉(zhuǎn)移酶JMJD1B抗體
xy-0702R Junctophilin-2親聯(lián)蛋白2抗體
xy-12387R KIF13B驅(qū)動(dòng)蛋白家族蛋白13B抗體
xy-12388R KIF7驅(qū)動(dòng)蛋白家族蛋白7抗體
xy-12395R KAT3ACREB結(jié)合蛋白抗體
xy-10056R KNDC1腦蛋白9抗體
xy-12371R Kindlin 2絲裂原誘導(dǎo)蛋白2抗體
xy-15508R KLF17鋅指蛋白393抗體
xy-3821R KDM1組蛋白賴氨酸特異性脫甲基酶1抗體
xy-8177R KIF11驅(qū)動(dòng)蛋白樣蛋白1抗體（甲狀腺激素受體相互作用蛋白5）
xy-8170R KMT3B組蛋白甲基化KMT3B抗體（雄激素受體激活蛋白）
xy-3762R Kv4.3離子通道蛋白Kv4.3抗體
xy-6893R KLLN Killin-p53調(diào)節(jié)復(fù)制抑制蛋白抗體
xy-6127R Lysyl tRNA synthetase賴氨酸t(yī)RNA的連接酶抗體
xy-7040R Kidins220220kDa蛋白激酶D相互作用蛋白抗體
xy-7041R phospho-Kidins220 (Ser918)磷酸化220kDa蛋白激酶D相互作用蛋白抗體
xy-4642R KRV-VP1 + KRV-VP2 (C-terminus)基爾曼氏細(xì)小病毒VP1/VP2抗體(大鼠潛在病毒KRV)C端
xy-6760R KCNQ1鉀離子通道蛋白家族KCNQ1抗體
xy-5708R KMT1A組蛋白H3 K9甲基轉(zhuǎn)移酶抗體
xy-6346R KAT13D生物鐘KAT13D蛋白抗體
xy-9628R KLHL36Kelch樣蛋白36抗體
xy-12170R KCC4鉀氯離子轉(zhuǎn)運(yùn)蛋白KCC4抗體
xy-12171R phospho-KCNA3(Tyr135)磷酸化離子通道蛋白Kv1.3抗體
xy-12172R KCNE4鉀離子通道蛋白家族成員4抗體