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NUP98 抗體

抗原
Nucleoporin 98kDa (NUP98)
別名
CG10198, CG10201, DmelCG10198, Nup 96, Nup 98, Nup-98, Nup96, Nup98, Nup98-Nup96, Nup98/96, l(3)95BCd, nup145, nup98-96, GB12688, NUP98, 4732457F17, AI849286, im:7151238, zgc:113968, zgc:63593, ADIR ... show more
CG10198, CG10201, DmelCG10198, Nup 96, Nup 98, Nup-98, Nup96, Nup98, Nup98-Nup96, Nup98/96, l(3)95BCd, nup145, nup98-96, GB12688, NUP98, 4732457F17, AI849286, im:7151238, zgc:113968, zgc:63593, ADIR2, NUP196, NUP96 show less
抗原表位
其他選擇 N-Term
AA 1-606(5),N-Term (4),AA 1-110 (3),AA 600-650 (2),AA 900-950 (2),AA 1650-1700 (1),AA 201-250 (1),AA 568-776 (1),AA 629-894 (1),Leu518 (1),Pro671 (1)
適用
其他選擇 Rat ((Rattus)), Murine, Bovine, Dog (Canine), Human, Chicken
Human(30),Murine (5),Rat ((Rattus)) (4),Chicken (2),Bovine (2),Dog (Canine) (2),Xenopus laevis (2),Fruit Fly (Drosophila melanogaster) (1),Zebrafish (1),Zebrafish (Danio rerio) (1)
宿主
其他選擇 Rabbit
Rabbit(20),Mouse (11)
克隆類型
多克隆
應(yīng)用范圍
其他選擇 Western Blotting (WB)
Western Blotting (WB)(27),Immunoprecipitation (IP) (11),ELISA (7),Immunoassay (IA) (4),Immunofluorescence (IF) (4),Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) (4),Immunocytochemistry (ICC) (3),Immunohistochemistry (Frozen Sections) (IHC (fro)) (2),Immunohistochemistry (IHC) (1)
[Pubmed] 1 reference available
規(guī)格 50 μg
發(fā)貨至 中國 (更改)
發(fā)貨時間 9至12個工作日

NUP98 抗體

產(chǎn)品細節(jié)

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產(chǎn)品細節(jié)

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免疫原 Synthetic peptide directed towards the N terminal of human NUP98
序列 EELRLEDYQA NRKGPQNQVG AGTTTGLFGS SPATSSATGL FSSSTTNSGF
預(yù)測反應(yīng) Bovine : 100 %, Horse : 100 %, Human : 100 %, Rabbit : 100 %, Rat : 100 %, Dog : 90 %, Guinea pig : 90 %, Mouse : 90 %, Pig : 90 %
產(chǎn)品特性 This is a rabbit polyclonal antibody against NUP98. It was validated on Western Blot using a cell lysate as a positive control.
純化方法 Affinity Purified

目標詳細情況

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別名 NUP98
背景 The nuclear pore complex (NPC) is comprised of approximay 50 unique proteins collectively known as nucleoporins. The 98 kD nucleoporin is localized to the nucleoplasmic side of the NPC. Rat studies show that the 98 kD nucleoporin functions as one of several docking site nucleoporins of transport substrates. The human gene has been shown to fuse to several genes following chromsome translocatons in acute myelogenous leukemia (AML) and T-cell acute lymphocytic leukemia (T-ALL). This gene is one of several genes located in the imprinted gene domain of 11p15.5, an important tumor-suppressor gene region. Alterations in this region have been associated with the Beckwith-Wiedemann syndrome, Wilms tumor, rhabdomyosarcoma, adrenocortical carcinoma, and lung, ovarian, and breast cancer. Signal-mediated nuclear import and export proceed through the nuclear pore complex (NPC), which is comprised of approximay 50 unique proteins collectively known as nucleoporins. The 98 kD nucleoporin is generated through a biogenesis pathway that involves synthesis and proteolytic cleavage of a 186 kD precursor protein. This cleavage results in the 98 kD nucleoporin as well as a 96 kD nucleoporin, both of which are localized to the nucleoplasmic side of the NPC. Rat studies show that the 98 kD nucleoporin functions as one of several docking site nucleoporins of transport substrates. The human gene has been shown to fuse to several genes following chromsome translocatons in acute myelogenous leukemia (AML) and T-cell acute lymphocytic leukemia (T-ALL). This gene is one of several genes located in the imprinted gene domain of 11p15.5, an important tumor-suppressor gene region. Alterations in this region have been associated with the Beckwith-Wiedemann syndrome, Wilms tumor, rhabdomyosarcoma, adrenocortical carcinoma, and lung, ovarian, and breast cancer. Alternative splicing of this gene results in several transcript variants, however, not all variants have been fully described.
分子量 98 kDa
基因ID 4928
NCBI Accession NM_005387, NP_005378
UniProt A8KA17
研究領(lǐng)域 Chromatin and Nuclear Signaling

使用細節(jié)

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應(yīng)用備注 Optimal working dilutions should be determined experimentally by the investigator.
說明

Antigen size: 937 AA

限制 For Research Use only

貯存及處理

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狀態(tài) Lyophilized
溶解方式 Add 50 µL of distilled water.
濃度 1 mg/mL
緩沖液 PBS buffer with 2 % sucrose
注意事項 Avoid repeated freeze-thaw cycles.
儲存條件 -20 °C
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