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LCK抗體

抗原
Lymphocyte-Specific Protein tyrosine Kinase (LCK)
別名 zgc:136695, LCK, Hck-3, Lsk, Lskt, p56, p56Lck, LSK, YT16, p56lck, pp58lck, P56LCK, tkl, Lck1, Lcktkr
抗原表位
其他選擇 N-Term
pTyr505(39),N-Term (29),pTyr394 (21),pTyr393 (20),pTyr192 (11),pSer59 (10),Internal Region (9),AA 22-36 (8),C-Term (8),AA 19-47 (7),Tyr505 (6),AA 1-539 (4),AA 39-52 (3),AA 392-396 (3),AA 480-509 (3),Tyr192 (3),AA 1-225 (2),AA 1-66 (2),AA 20-47 (2),AA 23-52 (2),Ser59 (2),Tyr393 (2),AA 1-100 (1),AA 1-255 (1),AA 1-298 (1),AA 1-58 (1),AA 161-210 (1),AA 21-70 (1),AA 239-489 (1),AA 26-75 (1),AA 311-509 (1),AA 361-410 (1),AA 460-509 (1),AA 59-108 (1),Gly534 (1),Leu186 (1),Leu387 (1),Ser158 (1),Ser736 (1),Ser737 (1),Ser738 (1),Ser742 (1),Ser75 (1),pSer540 (1),phosphospecific (1)
適用
其他選擇 Murine, Rat ((Rattus)), Bovine, Dog (Canine), Pig (Porcine), Human
Human(277),Murine (145),Rat ((Rattus)) (122),Chicken (15),Bovine (12),Dog (Canine) (12),Pig (Porcine) (12)
宿主
其他選擇 Rabbit
Rabbit(226),Mouse (57),Goat (4)
克隆類型
多克隆
標記
其他選擇 非結(jié)合性
Biotin(5),FITC (5),HRP (5),Alexa Fluor 350 (3),Alexa Fluor 488 (3),Alexa Fluor 555 (3),Alexa Fluor 647 (3),Cy3 (3),Cy5 (3),Cy5.5 (3),Cy7 (3),APC (2),Alkaline Phosphatase (AP) (2),PE (2)
應用范圍
其他選擇 Western Blotting (WB)
Western Blotting (WB)(254),ELISA (111),Immunoprecipitation (IP) (48),Immunohistochemistry (IHC) (42),Immunofluorescence (IF) (34),Immunofluorescence (Paraffin-embedded Sections) (IF (p)) (30),Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) (24),Flow Cytometry (FACS) (17),Immunocytochemistry (ICC) (13),Functional Studies (Func) (7),Immunohistochemistry (Frozen Sections) (IHC (fro)) (7),Immunohistochemistry (Frozen Paraffin-embedded Sections) (IHC (frpe)) (5),Enzyme Immunoassay (EIA) (4),RNA Interference (RNAi) (2),Immunoassay (IA) (1),Proximity Ligation Assay (PLA) (1)
[Pubmed] 1 reference available
規(guī)格 50 μg
發(fā)貨至 中國 (更改)
發(fā)貨時間 9至12個工作日

LCK抗體

產(chǎn)品細節(jié)

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產(chǎn)品細節(jié)

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免疫原 Synthetic peptide directed towards the N terminal of human LCK
序列 PSHDGDLGFE KGEQLRILEQ SGEWWKAQSL TTGQEGFIPF NFVAKANSLE
預測反應 Bovine : 100 %, Dog : 100 %, Guinea pig : 100 %, Horse : 100 %, Human : 100 %, Mouse : 100 %, Pig : 100 %, Rabbit : 100 %, Rat : 100 %, Sheep : 90 %
產(chǎn)品特性 This is a rabbit polyclonal antibody against LCK. It was validated on Western Blot using a cell lysate as a positive control.
純化方法 Affinity Purified

目標詳細情況

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目標詳細情況

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別名 LCK
背景 LCK is a member of the Src family of protein tyrosine kinases (PTKs). It is a key signaling molecule in the selection and maturation of developing T-cells. It contains N-terminal sites for myristylation and palmitylation, a PTK domain, and SH2 and SH3 domains which are involved in mediating protein-protein interactions with phosphotyrosine-containing and proline-rich motifs, respectively. LCK localizes to the plasma membrane and pericentrosomal vesicles, and binds to cell surface receptors, including CD4 and CD8, and other signaling molecules.This gene is a member of the Src family of protein tyrosine kinases (PTKs). The encoded protein is a key signaling molecule in the selection and maturation of developing T-cells. It contains N-terminal sites for myristylation and palmitylation, a PTK domain, and SH2 and SH3 domains which are involved in mediating protein-protein interactions with phosphotyrosine-containing and proline-rich motifs, respectively. The protein localizes to the plasma membrane and pericentrosomal vesicles, and binds to cell surface receptors, including CD4 and CD8, and other signaling molecules. Multiple alternatively spliced variants, encoding the same protein, have been described.
分子量 58 kDa
基因ID 3932
NCBI Accession NP_001036236, NM_001042771
UniProt P06239
研究領域 Signaling

使用細節(jié)

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使用細節(jié)

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應用備注 Optimal working dilutions should be determined experimentally by the investigator.
說明

Antigen size: 509 AA

限制 For Research Use only

貯存及處理

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貯存及處理

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狀態(tài) Lyophilized
溶解方式 Add 50 µL of distilled water.
濃度 1 mg/mL
緩沖液 PBS buffer with 2 % sucrose
注意事項 Avoid repeated freeze-thaw cycles.
儲存條件 -20 °C
儲存方法 For longer periods of storage, store at -20 °C

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