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NRG1抗體

抗原
Neuregulin 1 (NRG1)
別名
NRG1, wu:fm70e01, DKFZp459A1838, HPRG, HRGP, THPH11, HRG1, ARIA, GGF, GGF2, HGL, HRG, HRGA, MST131, NDF, SMDF, 6030402G23Rik, D230005F13Rik, GGFII, HRGalpha, Hgl, pro-neuregulin-1, NRG-1, heregulin, n ... show more
NRG1, wu:fm70e01, DKFZp459A1838, HPRG, HRGP, THPH11, HRG1, ARIA, GGF, GGF2, HGL, HRG, HRGA, MST131, NDF, SMDF, 6030402G23Rik, D230005F13Rik, GGFII, HRGalpha, Hgl, pro-neuregulin-1, NRG-1, heregulin, nrg1-A show less
抗原表位
其他選擇 Isoform beta 1
Internal Region(12),AA 1-525 (10),N-Term (10),Isoform 10 (7),Middle Region (6),Extracellular Domain (5),AA 1-241 (3),AA 20-241 (3),AA 13-259 (2),AA 198-229 (2),AA 20-242 (2),AA 1-211 (1),AA 1-296 (1),AA 1-50 (1),AA 166-280 (1),AA 264-393 (1),AA 328-640 (1),AA 614-639 (1),C-Term (1),Center (1),Isoform beta 1 (1),Tyr4 (1)
適用
其他選擇 Human
Human(109),Rat ((Rattus)) (47),Murine (35),Chicken (12),Dog (Canine) (12),Guinea Pig (12),Pig (Porcine) (12),Rabbit (1)
宿主
其他選擇 Mouse
Rabbit(101),Mouse (25)
克隆類型 (克隆位點)
單克隆 (3)
標(biāo)記
其他選擇 非結(jié)合性
Biotin(12),FITC (2),HRP (2),APC (1),Alexa Fluor 350 (1),Alexa Fluor 488 (1),Alexa Fluor 555 (1),Alexa Fluor 647 (1),Alkaline Phosphatase (AP) (1),Cy3 (1),Cy5 (1),Cy5.5 (1),Cy7 (1),PE (1)
應(yīng)用范圍
其他選擇 Western Blotting (WB)
Western Blotting (WB)(99),ELISA (47),Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) (38),Immunohistochemistry (IHC) (32),Immunoprecipitation (IP) (13),Immunohistochemistry (Frozen Sections) (IHC (fro)) (11),Immunofluorescence (Paraffin-embedded Sections) (IF (p)) (10),Flow Cytometry (FACS) (9),Immunocytochemistry (ICC) (9),Blocking Reagent (BR) (7),Enzyme Immunoassay (EIA) (5),Immunoassay (IA) (4),Immunofluorescence (IF) (3),Immunohistochemistry (Frozen Paraffin-embedded Sections) (IHC (frpe)) (3),Immunohistochemistry (Formalin-fixed Sections) (IHC (f)) (1),Neutralization (Neut) (1)
規(guī)格 50 μg
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NRG1抗體

產(chǎn)品細(xì)節(jié)

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產(chǎn)品細(xì)節(jié)

顯示 隱藏
免疫原 A synthetic peptide corresponding to the center region of the human NRG1 isoform beta 1.
克隆位點 3
亞型 IgG2b
特異性 Human NRG1-beta 1
交叉反應(yīng) （詳細(xì)） No cross-reactivity in WB with Human NRG1-alpha
產(chǎn)品特性 This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, a synthetic peptide corresponding to the center region of the human NRG1 isoform beta 1. The IgG fraction of the cell culture supernatant was purified by Protein A affinity chromatography.
純化方法 Affinity Purified
過濾 0.2 μm filtered

目標(biāo)詳細(xì)情況

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目標(biāo)詳細(xì)情況

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別名 NRG1
背景 Neuregulin 1 or NRG1 is one of four proteins in the neuregulin family that act on the EGFR family of receptors. This growth factor was originally identified as a 44-kD glycoprotein that interacts with the NEU / ERBB2 receptor tyrosine kinase to increase its phosphorylation on tyrosine residues. NRG1 is a trophic factor that has been implicated in neural development, neurotransmission, and synaptic plasticity. NRG1 has multiple isoforms that are generated by usage of different promoters and alternative splicing of a single gene. Neuregulin 1 (NRG1) is essential for the development and function of multiple organ systems, and its dysregulation has been linked to diseases such as cancer and schizophrenia. NRG1 is a schizophrenia candidate gene and plays an important role in brain development and neural function. Schizophrenia is a complex disorder, with etiology likely due to epistasis.
研究領(lǐng)域 Neurology, Glia marker

使用細(xì)節(jié)

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使用細(xì)節(jié)

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應(yīng)用備注 Western blot - WB: 1-2 μg/mL
限制 For Research Use only

貯存及處理

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貯存及處理

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緩沖液 PBS with 5% trehalose
儲存液 Without preservative
注意事項 Preservative-Free. Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.
儲存條件 4 °C/-20 °C/-80 °C
儲存方法 This antibody can be stored at 2 °C-8 °C for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20 °C to -70 °C.
有效期 12 months

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