IL1R1抗體 返回列表頁

IL1R1抗體

抗原
Interleukin 1 Receptor, Type I (IL1R1)
別名 CD121A, D2S1473, IL-1R-alpha, IL1R, IL1RA, P80, CD121a, CD121b, IL-iR, Il1r-1
抗原表位
其他選擇 AA 1-332
Extracellular Domain(20),C-Term (11),AA 1-352 (8),AA 421-450 (7),AA 1-332 (5),pTyr496 (3),AA 1-338 (2),AA 1-569 (2),AA 21-109 (2),AA 474-503 (2),AA 119-217 (1),AA 120-208 (1),AA 18-127 (1),AA 20-338 (1),AA 226-318 (1),AA 275-325 (1),AA 342-558 (1),AA 386-553 (1),AA 505-569 (1)
適用
其他選擇 Human
Human(62),Murine (29),Rat ((Rattus)) (13)
宿主
其他選擇 Rabbit
Rabbit(54),Mouse (21),Rat (17),Hamster (10),Goat (1),Sheep (1)
克隆類型
多克隆
標(biāo)記
其他選擇 非結(jié)合性
Biotin(5),APC (2),Alkaline Phosphatase (AP) (1),CF (1),FITC (1),HRP (1),PE (1)
zui低檢測濃度 0.00245 ng/well
應(yīng)用范圍
其他選擇 ELISA
Western Blotting (WB)(61),ELISA (59),Immunoprecipitation (IP) (20),Flow Cytometry (FACS) (16),Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) (15),Immunohistochemistry (IHC) (14),Radioimmunoassay (RIA) (14),Immunohistochemistry (Frozen Sections) (IHC (fro)) (10),Immunocytochemistry (ICC) (8),Enzyme Immunoassay (EIA) (6),Functional Studies (Func) (6),Neutralization (Neut) (3),Immunoassay (IA) (2),Immunodiffusion (ID) (2),Immunofluorescence (IF) (2),Immunohistochemistry (Frozen Paraffin-embedded Sections) (IHC (frpe)) (2)
[Pubmed] 1 reference available
規(guī)格 100 μg
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IL1R1抗體

產(chǎn)品細(xì)節(jié)

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產(chǎn)品細(xì)節(jié)

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亞型 IgG
特異性 Human IL1R1 / CD121a
產(chǎn)品特性 Produced in rabbits immunized with purified, recombinant Human IL1R1 (rhIL1R1, NP_000868.1, Met 1-Thr 332). Total IgG was purified by Protein A affinity chromatography.
純化方法 Affinity Purified
過濾 0.2 μm filtered

目標(biāo)詳細(xì)情況

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目標(biāo)詳細(xì)情況

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別名 IL1R1
背景 Interleukin 1 receptor, type I (IL-1R1) also known as CD121a (Cluster of Differentiation 121a), is an interleukin receptor. IL-1R1/CD121a is a cytokine receptor that belongs to the interleukin 1 receptor family. This protein is a receptor for interleukin alpha (IL1A), interleukin beta (IL1B), and interleukin 1 receptor, type I (IL1R1/IL1RA). IL-1R1/CD121a is an important mediator involved in many cytokine induced immune and inflammatory responses. This protein has been characterized by pharmacological and molecular techniques in the mouse brain. The spindle-shaped astrocytes enclose the wound, separating the healthy from damaged neural tissue. The shape change and subsequent repair processes are IL-1β activity-dependent, acting through the IL-1 type 1 receptor (IL-1R1), as co-application of the IL-1type 1 receptor antagonist protein (IL-1ra) blocks IL-1β induced effects. In the spleen, a slight increase in IL-1R AcP and IL-1R1 was observed during the first hours following LPS stimulation. In conclusion, IL-1R AcP mRNA is expressed in the brain and in other tissues where IL-1R1/CD121a transcripts are found. However, the regulation of its expression is distinct from IL-1R1/CD121a. The high level of expression and the lack of regulation of IL-1R AcP transcripts in the brain under inflammatory conditions suggest that the protein might be constitutively expressed in excess.
NCBI Accession NP_000868.1
研究領(lǐng)域 Immunology

使用細(xì)節(jié)

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使用細(xì)節(jié)

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應(yīng)用備注 ELISA ELISA: 0.5-1.0 μg/mL This antibody can be used at 0.5-1.0 μg/mL with the appropriate secondary reagents to detect Human IL1R1. The detection limit for Human IL1R1 is 0.00245 ng/well.
限制 For Research Use only

貯存及處理

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貯存及處理

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緩沖液 PBS with 5% trehalose
儲(chǔ)存液 Without preservative
注意事項(xiàng) Preservative-Free. Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.
儲(chǔ)存條件 4 °C/-20 °C/-80 °C
儲(chǔ)存方法 This antibody can be stored at 2 °C-8 °C for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20 °C to -70 °C.
有效期 12 months

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