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PECAM1 抗體

抗原
Plaet/endothelial Cell Adhesion Molecule (PECAM1)
別名 CD31, CD31/EndoCAM, GPIIA', PECA1, PECAM-1, endoCAM, C85791, Cd31, Pecam
抗原表位
其他選擇 AA 1-601
C-Term(54),AA 1-601 (15),pTyr713 (14),AA 511-540 (5),Extracellular Domain (5),Internal Region (5),N-Term (5),AA 425-591 (4),AA 730-734 (4),AA 1-738 (3),AA 199-287 (3),AA 29-738 (2),AA 29-739 (2),AA 508-536 (2),AA 690-718 (2),pTyr702 (2),AA 100-300 (1),AA 18-590 (1),AA 18-90 (1),AA 226-389 (1),AA 231-280 (1),AA 288-552 (1),AA 421-629 (1),AA 459-624 (1),AA 660-709 (1),AA 686-735 (1),AA 78-214 (1),Ala280 (1),Thr224 (1),Thr709 (1)
適用
其他選擇 Human
Human(403),Murine (201),Rat ((Rattus)) (59),Pig (Porcine) (38),Dog (Canine) (26),Bovine (20),Sheep (Ovine) (10),Monkey (5),Hamster (2),Goat (1),Rhesus Monkey (1)
宿主
其他選擇 Mouse
Mouse(295),Rabbit (164),Rat (100),Goat (4),Hamster (3)
克隆類型 (克隆位點)
單克隆 (13)
標(biāo)記
其他選擇 非結(jié)合性
FITC(59),Biotin (49),PE (46),APC (19),PE-Cy7 (5),HRP (4),PerCP (4),Allophycocyanin (3),Alexa Fluor 350 (2),Alexa Fluor 488 (2),Alexa Fluor 555 (2),Alexa Fluor 647 (2),Cy3 (2),Cy5 (2),Cy5.5 (2),Cy7 (2),Cy7,PE (2),DyLight 488 (2),DyLight 550 (2),DyLight 650 (2),EFluor 605NC (2),PE,Cy7 (2),PE-DyLight 594 (2),Alkaline Phosphatase (AP) (1)
應(yīng)用范圍
其他選擇 Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
Flow Cytometry (FACS)(316),Western Blotting (WB) (213),Immunohistochemistry (IHC) (135),Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) (128),ELISA (99),Immunofluorescence (IF) (82),Immunoprecipitation (IP) (64),Immunohistochemistry (Frozen Sections) (IHC (fro)) (62),Immunocytochemistry (ICC) (34),Immunohistochemistry (Frozen Paraffin-embedded Sections) (IHC (frpe)) (21),Immunofluorescence (Paraffin-embedded Sections) (IF (p)) (20),Functional Studies (Func) (19),Enzyme Immunoassay (EIA) (10),Immunofluorescence (Cultured Cells) (IF (cc)) (10),Immunohistochemistry (Formalin-fixed Sections) (IHC (f)) (5),Immunoassay (IA) (4),Blocking Reagent (BR) (2),Fluorescence Microscopy (FM) (1),Immunohistochemistry (Fixed) (IHC (fx)) (1),Intracellular Staining (ICS) (1),Proximity Ligation Assay (PLA) (1)
規(guī)格 50 μg
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PECAM1 抗體

產(chǎn)品細(xì)節(jié)

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產(chǎn)品細(xì)節(jié)

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免疫原 Recombinant Human CD31 protein
克隆位點 13
亞型 IgG1
特異性 Human CD31 / PECAM1
交叉反應(yīng) （詳細(xì)） No cross-reactivity in ELISA with Human CD54 Human CD62 Human CD106 Human cell lysate (293 cell line)
產(chǎn)品特性 This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human CD31 / PECAM1 extracellular domain (rhCD31, Met 1-Lys 601, NP_000433.3). The IgG fraction of the cell culture supernatant was purified by Protein A affinity chromatography.
純化方法 Affinity Purified
過濾 0.2 μm filtered

目標(biāo)詳細(xì)情況

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目標(biāo)詳細(xì)情況

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別名 PECAM1
背景 The CD31 adhesion molecule, also known as plaet-endothelial cell adhesion molecule-1 (PECAM-1), is a 130-kDa transmembrane glycoprotein expressed by endothelial cells, plaets, monocytes, neutrophils, and certain T cell subsets, and is the only known member of the CAM family on plaets. PECAM-1 has six Ig-homology domains that share sequence similarity with cellular adhesion molecules within the extracellular region, and an immunoreceptor tyrosine-based inhibitory motif (ITIM) in the cytoplasmic region. Accordingly, CD31acts as a signaling molecule when appropriay engaged and creates docking sites for the Src homology 2 domain-bearing protein tyrosine phosphatase (SHP)-1 and SHP-2. PECAM-1 mediates the homotypic or heterotypic cell adhesion by binding to itself or the leukocyte integrin αvβ3, and thus plays a role in neutrophil recruitment in inflammatory responses, transendothelial migration of leukocytes, as well as in cardiovascular development. In addition, it has been shown that CD31 expression is up- regulated by LPS stimulation, and might function as a feedback negative regulator of LPS inflammatory response in macrophages.
NCBI Accession NP_000433.3

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使用細(xì)節(jié)

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應(yīng)用備注 Immunochemistry - IHC-P: 5-20 μg/mL
限制 For Research Use only

貯存及處理

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貯存及處理

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緩沖液 PBS with 5% trehalose
儲存液 Without preservative
注意事項 Preservative-Free. Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thawcycles.
儲存條件 4 °C/-20 °C/-80 °C
儲存方法 This antibody can be stored at 2 °C-8 °C for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20 °C to -70 °C.
有效期 12 months

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