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CSF1R 抗體

抗原
Colony Stimulating Factor 1 Receptor (CSF1R)
別名 MGC89146, C-FMS, CD115, CSF-1R, CSFR, FIM2, FMS, HDLS, M-CSF-R, AI323359, Csfmr, Fim-2, Fms, M-CSFR, CSF-1-R, c-fms, mrfms, CSF1, M-CSF, csf1r, fms, panther
抗原表位
其他選擇 AA 1-512
C-Term(32),pTyr699 (19),pTyr723 (18),pTyr809 (14),AA 1-512 (9),pTyr561 (9),AA 894-923 (7),Internal Region (7),AA 1-511 (6),Tyr809 (6),Extracellular Domain (5),pTyr708 (5),AA 700-710 (3),AA 20-511 (2),AA 20-512 (2),AA 21-120 (2),AA 344-497 (2),AA 543-922 (2),AA 734-744 (2),AA 781-830 (2),AA 895-923 (2),Ser276 (2),Tyr561 (2),Tyr699 (2),Tyr708 (2),Tyr723 (2),pTyr559 (2),pTyr706 (2),AA 531-580 (1),AA 646-939 (1),AA 669-718 (1),AA 691-740 (1),AA 940-971 (1),Asn805 (1),Gln718 (1),Glu557 (1),Ile803 (1),Ser274 (1),Ser275 (1),Ser278 (1)
適用
其他選擇 Human
Human(204),Murine (143),Rat ((Rattus)) (62),Dog (Canine) (28),Bovine (15),Zebrafish (7),Cat (4),Horse (Equine) (2),Guinea Pig (1),Pig (Porcine) (1)
宿主
其他選擇 Mouse
Rabbit(195),Rat (76),Mouse (14),Goat (9),Sheep (3)
克隆類型 (克隆位點(diǎn))
單克隆 (1H10A7A4)
標(biāo)記
其他選擇 非結(jié)合性
Biotin(21),PE (21),APC (9),FITC (7),HRP (7),Alkaline Phosphatase (AP) (3),Alexa Fluor 350 (2),Alexa Fluor 488 (2),Alexa Fluor 555 (2),Alexa Fluor 647 (2),Allophycocyanin (2),Cy3 (2),Cy5 (2),Cy5.5 (2),Cy7 (2)
zui低檢測(cè)濃度 0.0195 ng/well
應(yīng)用范圍
其他選擇 ELISA
Western Blotting (WB)(166),ELISA (148),Flow Cytometry (FACS) (85),Immunohistochemistry (IHC) (84),Immunofluorescence (IF) (33),Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) (25),Immunofluorescence (Paraffin-embedded Sections) (IF (p)) (20),Immunocytochemistry (ICC) (13),Immunofluorescence (Cultured Cells) (IF (cc)) (10),Immunohistochemistry (Frozen Sections) (IHC (fro)) (10),Immunoprecipitation (IP) (8),Functional Studies (Func) (7),Immunohistochemistry (Frozen Paraffin-embedded Sections) (IHC (frpe)) (4),Blocking Reagent (BR) (3),Enzyme Immunoassay (EIA) (3),Proximity Ligation Assay (PLA) (2),Fluorescence Microscopy (FM) (1),Neutralization (Neut) (1)
[Pubmed] 1 reference available
規(guī)格 50 μg
發(fā)貨至 中國(guó) (更改)

CSF1R 抗體

產(chǎn)品細(xì)節(jié)

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產(chǎn)品細(xì)節(jié)

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克隆位點(diǎn) 1H10A7A4
亞型 IgG1
特異性 Human M-CSFR / CSF1R / CD115
交叉反應(yīng) （詳細(xì)） No cross-reactivity in ELISA with Human GCSFR / CSF3R / CD114 Human GMCSFR-alpha / CSF2RA / CD116 Human PDGFR-beta / CD140b
產(chǎn)品特性 This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human M-CSFR extracellular domain (rh M- CSFR, Met 1-Glu 512, NP_005202.2). The IgG fraction of the cell culture supernatant was purified by Protein A affinity chromatography.
過(guò)濾 0.2 μm filtered

目標(biāo)詳細(xì)情況

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目標(biāo)詳細(xì)情況

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別名 CSF1R
背景 M-CSFR encoded by the proto-oncogene c-fms is the receptor for colony stimulating factor 1 (CSF1R), a cytokine involved in the proliferation, differentiation, and activation of macrophages. This cell surface glycoprotein is consisted by an extracellular ligand-binding domain, a single membrane-spanning segment, and an intracellular tyrosine kinase domain. Binding of CSF1 activates the receptor kinase, leading to "autophosphorylation" of receptor subunits and the concomitant phosphorylation of a series of cellular proteins on tyrosine residues. CSF1R is a tyrosine kinase receptor that is absoluy required for macrophage differentiation and thus occupies a central role in hematopoiesis. CSF1 and its receptor (CSF1R, product of c-fms proto-oncogene) were initially implicated as essential for normal monocyte development as well as for trophoblastic implantation. This apparent role for CSF1/CSF1R in normal mammary gland development is very intriguing because this receptor/ligand pair has also been found to be important in the biology of breast cancer in which abnormal expression of CSF1 and its receptor correlates with tumor cell invasiveness and adverse clinical prognosis. Tumor cell expression of CSF1R is under the control of several steroid hormones (glucocorticoids and progestins) and the binding of several bHLH transcription factors, while tumor cell expression of CSF-1 appears to be regulated by other hormones, some of which are involved in normal lactogenic differentiation. However, studies have demonstrated that CSF1 and CSF1R have additional roles in mammary gland development during pregnancy and lactation. The role of CSF1 and CSF1R in normal and neoplastic mammary development that may elucidate potential relationships of growth factor-induced biological changes in the breast during pregnancy and tumor progression.
NCBI Accession NP_005202.2

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使用細(xì)節(jié)

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應(yīng)用備注 ELISA ELISA: 0.5-1 μg/mL This antibody can be used at 0.5-1 μg/mL with the appropriate secondary reagents to detect MCSFR. The detection limit for MCSFR is approximay 0.0195 ng/well.
限制 For Research Use only

貯存及處理

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緩沖液 PBS with 5% trehalose
儲(chǔ)存液 Without preservative
注意事項(xiàng) Preservative-Free. Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.
儲(chǔ)存條件 4 °C/-20 °C/-80 °Cxy-11653R BHLHB9/p60TRPp60TRP蛋白抗體
xy-11654R BLMH博萊霉素水解酶抗體
xy-11655R Aggrecan短蛋白聚糖抗體
xy-8397R BTBD3BTB/POZ結(jié)構(gòu)域蛋白3抗體
xy-11505R BBS12巴爾得-別德?tīng)柧C合征相關(guān)蛋白12抗體
xy-12903R BZW1堿性亮氨酸拉鏈蛋白BZW1抗體
xy-6639R BMPR1B骨形態(tài)發(fā)生蛋白受體1B抗體
xy-6681R BNIP1Bcl2相互作用蛋白1抗體（轉(zhuǎn)化相關(guān)基因8蛋白）
xy-6614R BMP5骨形態(tài)發(fā)生蛋白5抗體
xy-6612R BMP15骨形態(tài)發(fā)生蛋白15抗體
xy-5903R Bcl2L2Bcl-2樣蛋白2抗體
xy-4292R BPI殺菌/通透性增強(qiáng)蛋白抗體
xy-4563R Bcl-2Bcl-2抗體
xy-8202R BRN4腦轉(zhuǎn)錄因子4蛋白抗體
xy-5042R Bile salt-activated lipase膽鹽激活脂肪酶抗體
xy-5041R BDH13-羥丁酸脫氫酶抗體
xy-5040R BAAT長(zhǎng)鏈脂肪酸?；o酶A水解酶抗體
xy-8444R Phospho-BRCA1(Ser988)磷酸化乳腺癌易感基因1抗體
xy-5215R phospho-BACE1 (Ser498)磷酸化β分泌酶抗體
xy-5216R Phospho-Bad (Ser118)磷酸化相關(guān)死亡促進(jìn)因子抗體
xy-5217R Phospho-Bad (Ser134)磷酸化相關(guān)死亡促進(jìn)因子抗體
xy-5220R Phospho-Bcl-2(Thr129)磷酸化Bcl-2抗體
xy-5221R Phospho-BRCA1 (Ser1189)磷酸化乳腺癌易感基因1抗體
xy-5222R Phospho-BRCA1 (Ser1423)磷酸化乳腺癌易感基因1抗體
xy-5223R Phospho-BMX (Tyr556)磷酸化非受體性蛋白酪氨酸激酶ETK抗體
xy-5224R phospho-B-Raf (Thr401)磷酸化B-Raf抗體
xy-4092R BACH1乳腺癌易感基因相互作用蛋白1抗體
xy-5226R phospho-BACH1 (Ser990)磷酸化乳腺癌易感基因相互作用蛋白1抗體
xy-5219R phospho-BAD (Ser99)磷酸化相關(guān)死亡促進(jìn)因子抗體
儲(chǔ)存方法 This antibody can be stored at 2 °C-8 °C for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20 °C to -70 °C.
有效期 12 months