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ICAM3抗體

抗原
Intercellular Adhesion Molecule 3 (ICAM3)
別名 ICAM3, CD50, CDW50, ICAM-R, ICAM-3, Icam3, TLN, Tlcn
抗原表位
其他選擇 AA 1-485
AA 1-485(15),pSer518 (10),AA 281-310 (7),C-Term (7),Internal Region (7),Ser518 (3),AA 30-485 (2),AA 259-491 (1),AA 30-547 (1),AA 30-548 (1),AA 312-547 (1),AA 484-533 (1),AA 497-547 (1),Domain D2 (1),Extracellular Domain (1),Gln514 (1)
適用
其他選擇 Human
Human(160)
宿主
其他選擇 Rabbit
Mouse(96),Rabbit (62),Sheep (1)
克隆類型
多克隆
標(biāo)記
其他選擇 非結(jié)合性
FITC(20),PE (14),Biotin (12),APC (3),HRP (2),Alexa Fluor 350 (1),Alexa Fluor 488 (1),Alexa Fluor 555 (1),Alexa Fluor 647 (1),Alkaline Phosphatase (AP) (1),Cy3 (1),Cy5 (1),Cy5.5 (1),Cy7 (1)
zui低檢測(cè)濃度 0.00245 ng/well
應(yīng)用范圍
其他選擇 ELISA
Flow Cytometry (FACS)(92),Western Blotting (WB) (54),ELISA (53),Immunoprecipitation (IP) (25),Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) (23),Immunofluorescence (IF) (16),Immunohistochemistry (IHC) (14),Immunofluorescence (Paraffin-embedded Sections) (IF (p)) (10),Neutralization (Neut) (10),Immunohistochemistry (Frozen Sections) (IHC (fro)) (8),Immunocytochemistry (ICC) (5),Functional Studies (Func) (4),Immunohistochemistry (Frozen Paraffin-embedded Sections) (IHC (frpe)) (2),Blocking Antibody (Inhibition) (1),Enzyme Immunoassay (EIA) (1),Intracellular Staining (ICS) (1),Radioimmunoassay (RIA) (1)
[Pubmed] 1 reference available
規(guī)格 100 μg
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ICAM3抗體

產(chǎn)品細(xì)節(jié)

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產(chǎn)品細(xì)節(jié)

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亞型 IgG
特異性 Human ICAM3 / CD50
產(chǎn)品特性 Produced in rabbits immunized with purified, recombinant Human ICAM3 / CD50 (rh ICAM3 / CD50, NP_002153.2, Met 1-His 485). Total IgG was purified by Protein A affinity chromatography.
純化方法 Affinity Purified
過(guò)濾 0.2 μm filtered

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目標(biāo)詳細(xì)情況

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別名 ICAM3
背景 The protein ICAM-3, also known as CD50, is a member of the intercellular adhesion molecule (ICAM) family consisting three members. It is a DC- SIGN ligand that is constitutively expressed on resting leukocytes, and is thus an important molecule for the first immune response. ICAM-3 comprises of five immunoglobulin-like domains, and binds LFA-1 through its two N-terminal domains. It functions not only as an adhesion molecule, but also as a potent signalling molecule. ICAM-3 binds to LFA-1 on antigen-presenting cells (APC) stabilizing the T cell-APC interaction, facilitating signaling through the CD3/TCR complex. However, recent evidence using cultured and transformed T cells suggests ICAM-3 may also function in signaling. It has been reported that CD50 molecule can play a role in developing functionally mature T lymphocytes and its expression increases during the maturation process of T lymphocytes. In addition, the interactions of ICAM-3 and LFA-1 facilitate HIV-1- induced virological synapse formation between T cells. ICAM-3 is associated with an increase of cellular radio-resistance and cancer cell proliferation. It could be considered as a candidate for anti-cancer drug development and as a cancer diagnostic marker.
NCBI Accession NP_002153.2
研究領(lǐng)域 Immunology, CD Antigens

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使用細(xì)節(jié)

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應(yīng)用備注 ELISA ELISA: 0.5-1 μg/mL This antibody can be used at 0.5-1 μg/mL with the appropriate secondary reagents to detect ICAM3. The detection limit for Human ICAM3 is approximay 0.00245 ng/well.
限制 For Research Use only

貯存及處理

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貯存及處理

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緩沖液 PBS with 5% trehalose
儲(chǔ)存液 Without preservative
注意事項(xiàng) Preservative-Free. Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.
儲(chǔ)存條件 4 °C/-20 °C/-80 °C
儲(chǔ)存方法 This antibody can be stored at 2 °C-8 °C for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20 °C to -70 °C.
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