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IFNAR2抗體

抗原
Interferon alpha/beta Receptor 2 (IFNAR2)
別名 AI747302, Ifnar-2, IFN-R, IFN-alpha-REC, IFNABR, IFNARB, IFN-R-2, IFNBR
抗原表位
其他選擇 AA 1-243
AA 1-243(9),Internal Region (5),AA 1-331 (2),AA 118-431 (1),AA 24-166 (1),C-Term (1),Chain beta (1)
適用
其他選擇 Human
Human(38),Murine (14),Rat ((Rattus)) (12)
宿主
其他選擇 Rabbit
Rabbit(29),Mouse (15),Goat (7)
克隆類型
多克隆
標(biāo)記
其他選擇 非結(jié)合性
PE(6),FITC (4),Alexa Fluor 350 (1),Alexa Fluor 488 (1),Alexa Fluor 555 (1),Alexa Fluor 647 (1),Biotin (1),Cy3 (1),Cy5 (1),Cy5.5 (1),Cy7 (1),HRP (1)
zui低檢測濃度 0.00245 ng/well
應(yīng)用范圍
其他選擇 ELISA
Western Blotting (WB)(20),ELISA (19),Flow Cytometry (FACS) (12),Immunofluorescence (Paraffin-embedded Sections) (IF (p)) (10),Immunohistochemistry (IHC) (7),Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) (6),Immunoassay (IA) (2),Immunofluorescence (IF) (2),Immunoprecipitation (IP) (2),Enzyme Immunoassay (EIA) (1),Functional Studies (Func) (1),Immunocytochemistry (ICC) (1),Immunohistochemistry (Frozen Paraffin-embedded Sections) (IHC (frpe)) (1),Immunohistochemistry (Frozen Sections) (IHC (fro)) (1)
[Pubmed] 2 references available
規(guī)格 100 μg
發(fā)貨至 中國 (更改)

IFNAR2抗體

產(chǎn)品細(xì)節(jié)

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產(chǎn)品細(xì)節(jié)

顯示 隱藏
亞型 IgG
特異性 Human IFNAR2 / IFNABR
產(chǎn)品特性 Produced in rabbits immunized with purified, recombinant Human IFNAR2 (rh IFNAR2, NP_997468.1, Met 1-Lys 243). Total IgG was purified by Protein A affinity chromatography .
純化方法 Affinity Purified
過濾 0.2 μm filtered

目標(biāo)詳細(xì)情況

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目標(biāo)詳細(xì)情況

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別名 IFNAR2
背景 Interferon-alpha/beta receptor beta chain (IFNAR2) is a type I membrane protein that forms one of the two chains of a receptor for interferons alpha and beta. Binding and activation of the receptor stimulates Janus protein kinases, which in turn phosphorylate several proteins, including STAT1 and STAT2. Initial cell-surface IFNAR2 expression at diagnosis assessed by flow cytometry widely distributed but showed overall significantly higher expression in CML patients when compared with normal controls. In 15 fresh patients who subsequently received IFNα therapy, IFNAR2 expression at diagnosis was significantly higher in cytogenetic good responders than in poor responders. Down-regulation of IFNAR2 expression during IFNα therapy was observed only in good responders but not in poor responders. The encoded protein also functions as an antiviral factor. IFNAR2 may associate with IFNAR1 to form the type I interferon receptor. This protein serves as a receptor for interferons alpha and beta. IFNAR2 is also involved in IFN-mediated STAT1, STAT2 and STAT3 activation. Isoform 1 and isoform 2 are directly involved in signal transduction due to their association with the TYR kinase, JAK1. Isoform 3 is a potent inhibitor of type I IFN receptor activity. Following binding of IFNα2, IFNAR2 is internalized, but, instead of being routed towards degradation as it is when complexed to IFNβ, it recycles back to the cell surface.
NCBI Accession NP_997468.1
研究領(lǐng)域 Cancer, Cytokines, Innate Immunity

使用細(xì)節(jié)

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使用細(xì)節(jié)

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應(yīng)用備注 ELISA ELISA: 0.5-1 μg/mL This antibody can be used at 0.5-1 μg/mL with the appropriate secondary reagents to detect Human IFNaR2. The detection limit for Human IFNaR2 is 0.00245 ng/well.
限制 For Research Use only

貯存及處理

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貯存及處理

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緩沖液 PBS with 5% trehalose
儲存液 Without preservative
注意事項 Preservative-Free. Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.
儲存條件 4 °C/-20 °C/-80 °C
儲存方法 This antibody can be stored at 2 °C-8 °C for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20 °C to -70 °C.
有效期 12 months

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