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TACSTD2抗體

抗原
Tumor-Associated Calcium Signal Transducer 2 (TACSTD2)
別名 Tpm-2, Trop-2, EGP-1, EGP1, GA733-1, GA7331, GP50, M1S1, TROP2, C80403, Ly97, Prp1
抗原表位
其他選擇 AA 1-274
AA 1-274(17),C-Term (10),Internal Region (10),AA 218-246 (7),AA 27-274 (4),AA 1-270 (2),AA 162-190 (2),Extracellular Domain (2),AA 1-47 (1),AA 19-294 (1),AA 275-303 (1),AA 82-268 (1),Center (1),Middle Region (1),N-Term (1),Phe167 (1)
適用
其他選擇 Human
Human(77),Murine (48),Rat ((Rattus)) (34),Bovine (13),Dog (Canine) (13),Chicken (12),Pig (Porcine) (1)
宿主
其他選擇 Mouse
Rabbit(72),Mouse (10),Goat (8),Rat (1)
克隆類型 (克隆位點(diǎn))
單克隆 (8C6C1D7)
標(biāo)記
其他選擇 非結(jié)合性
FITC(7),PE (4),APC (3),Biotin (3),HRP (3),Alexa Fluor 350 (2),Alexa Fluor 488 (2),Alexa Fluor 555 (2),Alexa Fluor 647 (2),CF (2),Cy3 (2),Cy5 (2),Cy5.5 (2),Cy7 (2),Alkaline Phosphatase (AP) (1)
應(yīng)用范圍
其他選擇 Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunocytochemistry (ICC), Immunofluorescence (IF)
Western Blotting (WB)(47),ELISA (38),Immunofluorescence (Paraffin-embedded Sections) (IF (p)) (20),Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) (19),Immunohistochemistry (IHC) (14),Flow Cytometry (FACS) (12),Immunofluorescence (IF) (8),Immunocytochemistry (ICC) (7),Enzyme Immunoassay (EIA) (2),Immunohistochemistry (Frozen Sections) (IHC (fro)) (1)
規(guī)格 50 μg
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TACSTD2抗體

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產(chǎn)品細(xì)節(jié)

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免疫原 Recombinant human TROP2 protein
克隆位點(diǎn) 8C6C1D7
亞型 IgG1
特異性 Human TROP2 / TACSTD2
交叉反應(yīng) （詳細(xì)） No cross-reactivity in WB and ELISA with Human BCAM / CD239 Human VCAM1 / CD106 Human ICAM1 / CD54 Human CD146 / MCAM / MUC18 Human CD171 / NCAML1 / L1CAM Human Cadherin-1 / E-cadherin / CDH1 / CD324 Cross reactivity Does not react with Mouse, RatDoes not react with Mouse, Rat
產(chǎn)品特性 This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, human cell-derived, recombinant human TROP2 extracellular domain (rh TROP2, NP_002344.2, Met 1-Thr 274). The IgG fraction of the cell culture supernatant was purified by Protein A affinity chromatography.
純化方法 Affinity Purified
過(guò)濾 0.2 μm filtered

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別名 TACSTD2
背景 Human TROP2, also referred to as tumor associated calcium signal transducer 2 (TACSTD2), GA733-1 or M1S1, is a cell surface glycoprotein highly expressed by human carcinomas. TROP2 encoding by an intronless gene was originally defined by the monoclonal antibody GA733, and is a member of a family of at least two type I membrane proteins. The other known member is GA733-2, also called EpCAM and TROP1. It has been suggested by studies that the GA733-1 gene was formed by the retroposition of the GA733-2 gene via an mRNA intermediate. The cytoplasmic tail of TROP2 possesses potential serine and tyrosine phosphorylation sites and a conserved phosphatidyl-inositol binding consensus sequence. TROP2 transduces an intracellular calcium signal and acts as a cell surface receptor, meanwhile is involved in the regulation of cell- cell adhesion. Accordingly, as a widespread stimulator of human cancer growth and a unique marker and causal factor of metastatic cancer, TROP2 is a possible candidate for diagnosis and molecular target therapy. Mutations of this gene result in gelatinous drop-like corneal dystrophy, an autosomal recessive disorder characterized by severe corneal amyloidosis leading to blindness.
NCBI Accession NP_002344.2

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應(yīng)用備注 Immunochemistry - IHC-P: 5-15 μg/mL ICC/IF: 15-30 μg/mL
限制 For Research Use only

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緩沖液 PBS with 5% trehalose
儲(chǔ)存液 Without preservative
注意事項(xiàng) Preservative-Free. Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.
儲(chǔ)存條件 4 °C/-20 °C/-80 °C
儲(chǔ)存方法 This antibody can be stored at 2 °C-8 °C for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20 °C to -70 °C.
有效期 12 months

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