ARSA 抗體 返回列表頁(yè)

ARSA 抗體

抗原
Arylsulfatase A (ARSA)
別名 ARSA, zgc:101575, arsa, AS-A, ASA, AW212749, As-2, As2, TISP73, MLD, mld
抗原表位
其他選擇 AA 1-507
C-Term(13),AA 1-507 (10),Internal Region (9),AA 1-506 (6),AA 408-439 (4),N-Term (3),Middle Region (2),AA 10-256 (1),AA 169-405 (1),AA 251-300 (1),AA 301-493 (1),AA 45-249 (1)
適用
其他選擇 Human
Human(84),Murine (51),Rat ((Rattus)) (43),Bovine (15),Dog (Canine) (15),Pig (Porcine) (14),Guinea Pig (1),Rabbit (1),Xenopus laevis (1)
宿主
其他選擇 Rabbit
Rabbit(69),Mouse (15),Goat (7)
克隆類型
多克隆
標(biāo)記
其他選擇 非結(jié)合性
Biotin(3),FITC (3),HRP (3),Alexa Fluor 350 (2),Alexa Fluor 488 (2),Alexa Fluor 555 (2),Alexa Fluor 647 (2),Cy3 (2),Cy5 (2),Cy5.5 (2),Cy7 (2),APC (1),Alkaline Phosphatase (AP) (1),PE (1)
zui低檢測(cè)濃度 0.039 ng/well
應(yīng)用范圍
其他選擇 ELISA
Western Blotting (WB)(64),ELISA (37),Immunohistochemistry (IHC) (20),Immunofluorescence (Paraffin-embedded Sections) (IF (p)) (19),Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) (7),Immunoassay (IA) (3),Immunoprecipitation (IP) (2),Immunofluorescence (IF) (1)
[Pubmed] 1 reference available
規(guī)格 100 μg
發(fā)貨至 中國(guó) (更改)

ARSA 抗體

產(chǎn)品細(xì)節(jié)

引用 貯存及處理 使用細(xì)節(jié) 目標(biāo)詳細(xì)情況 回頁(yè)首

產(chǎn)品細(xì)節(jié)

顯示 隱藏
亞型 IgG
特異性 Human Arylsulfatase-A / ARSA
產(chǎn)品特性 Produced in rabbits immunized with purified, recombinant Human ARSA (rh ARSA, NP_000478.2, Met 1-Ala 507). Total IgG was purified by Protein A affinity chromatography .
純化方法 Affinity Purified
過(guò)濾 0.2 μm filtered

目標(biāo)詳細(xì)情況

引用 貯存及處理 使用細(xì)節(jié) 回頁(yè)首

目標(biāo)詳細(xì)情況

顯示 隱藏
別名 ARSA
背景 Arylsulfatase A (ARSA) is synthesized as a 52KDa lysosomal enzyme. It is a member of the sulfatase family that is required for the lysosomal degradation of cerebroside-3-sulfate, a sphingolipid sulfate ester and a major constituent of the myelin sheet. Arylsulfatase A is activated by a required co- or posttranslational modification with the oxidation of cysteine to formylglycine. Metachromatic leukodystrophy (MLD) is a lysosomal storage disease in the central and peripheral nervous systems with severe and progressive neurological symptoms caused by the deficiency of Arylsulfatase A. Deficiency of this enzyme is also found in apparently healthy individuals, a condition for which the term pseudodeficiency is introduced. ARSA forms dimers after receiving three N-linked oligosaccharides in the endoplasmic reticulum, and then the dimers are transported to the Golgi where they receive mannose 6-phosphate recognition markers. And thus, ARSA is transported and delivered to dense lysosomes in a mannose 6-phosphate receptor-dependent manner. It has been shown that within the lysosomes, the ARSA dimers can oligomerize to an octamer in a pH-dependent manner. The ARSA deficiency leads to metachromatic leucodystrophy (MLD), a lysosomal storage disorder associated with severe and progressive demyelination in he central and peripheral nervous system. Additionally, the serum level of arylsulfatase A might be helpful in diagnosis of lung and central nervous system cancer.
NCBI Accession NP_000478.2
研究領(lǐng)域 Cancer, Organelles

使用細(xì)節(jié)

引用 貯存及處理 目標(biāo)詳細(xì)情況 回頁(yè)首

使用細(xì)節(jié)

顯示 隱藏
應(yīng)用備注 ELISA ELISA: 0.5-1 μg/mL This antibody can be used at 0.5-1 μg/mL with the appropriate secondary reagents to detect Human ARSA. The detection limit for Human ARSA is 0.039 ng/well.
限制 For Research Use only

貯存及處理

引用 使用細(xì)節(jié) 目標(biāo)詳細(xì)情況 回頁(yè)首

貯存及處理

顯示 隱藏
緩沖液 PBS with 5% trehalose
儲(chǔ)存液 Without preservative
注意事項(xiàng) Preservative-Free. Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.
儲(chǔ)存條件 4 °C/-20 °C/-80 °C
儲(chǔ)存方法 This antibody can be stored at 2 °C-8 °C for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20 °C to -70 °C.
有效期 12 months

xy-1516R CNTF Receptor alpha睫狀神經(jīng)營(yíng)養(yǎng)因子受體α抗體
xy-1520R CD7CD7抗體
xy-1620R CDX2尾型同源盒轉(zhuǎn)錄因子2抗體
xy-1432R CD68CD68抗體
xy-1428R Claudin 1緊密連接蛋白1抗體
xy-1539R CD46膜輔蛋白抗體
xy-1441R CXCL16CXC趨化因子16抗體
xy-1533R COX IV細(xì)胞色素c氧化酶IV亞型1抗體
xy-15061R C1orf2271號(hào)染色體開(kāi)放閱讀框227抗體
xy-15158R C2orf712號(hào)染色體開(kāi)放閱讀框71抗體
xy-1453R Caveolin-1細(xì)胞質(zhì)膜微囊蛋白-1抗體
xy-1470R CD82腫瘤轉(zhuǎn)移抑制蛋白1抗體
xy-0967R Caspase-12半胱胺酸蛋白酶蛋白-12抗體
xy-1431R CK17細(xì)胞角蛋白17抗體
xy-0979R CD38CD38抗體
xy-0980R CD38CD38抗體
xy-1592R CA I碳酸酐酶1抗體
xy-1709R CA II碳酸酐酶2抗體
xy-1593R CK II Alpha絲/蘇氨酸蛋白質(zhì)激酶抗體
xy-1594R CTNNA1α-連環(huán)蛋白抗體（鈣粘蛋白相關(guān)蛋白）Catenin α
xy-4299R CNTROB乳腺癌易感基因2相互作用蛋白抗體
xy-4297R CLIP170細(xì)胞質(zhì)連接蛋白1抗體
xy-4194R CD167b盤(pán)狀結(jié)構(gòu)域受體蛋白2抗體
xy-6030R CD200膜糖蛋白CD200抗體
xy-6034R CPA1胰羧肽酶A1抗體
xy-6035R Carboxypeptidase A2羧肽酶A2抗體
xy-6033R Contactin 3腦源性免疫球蛋白超家族蛋白3抗體
xy-6036R Carboxypeptidase B1胰羧肽酶B1抗體