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CDK2抗體

抗原
Cyclin-Dependent Kinase 2 (CDK2)
別名 MGC84068, cinp, CINP, p33(CDK2), A630093N05Rik, wu:fa10c02, zgc:56598, zgc:77684, eg1, CDKN2, cdk2L
抗原表位
其他選擇 AA 1-298
pThr160(42),C-Term (36),pThr14 (17),Thr160 (11),AA 1-298 (7),Internal Region (6),Thr14 (4),AA 158-162 (3),AA 94-198 (3),Middle Region (3),AA 230-260 (2),pTyr15 (2),AA 1-269 (1),AA 1-30 (1),AA 211-298 (1),AA 5-346 (1),AA 65-298 (1),AA 94-212 (1),N-Term (1),Ser226 (1),Tyr15 (1)
適用
其他選擇 Human
Human(203),Murine (112),Rat ((Rattus)) (103),Bovine (28),Dog (Canine) (17),Guinea Pig (12),Pig (Porcine) (12),Zebrafish (5),Chicken (4),Xenopus laevis (4),Monkey (3),Rabbit (2),Zebrafish (Danio rerio) (2),Zebrafish (Brachydanio rerio) (1)
宿主
其他選擇 Rabbit
Rabbit(185),Mouse (31),Sheep (1)
克隆類型
多克隆
標記
其他選擇 非結合性
Biotin(6),Alexa Fluor 350 (2),Alexa Fluor 488 (2),Alexa Fluor 555 (2),Alexa Fluor 647 (2),Cy3 (2),Cy5 (2),Cy5.5 (2),Cy7 (2),FITC (2),HRP (2),His tag (2),Biotin,His tag (1),Biotin,His tag,GST tag (1)
zui低檢測濃度 0.039 ng/well
應用范圍
其他選擇 ELISA
Western Blotting (WB)(187),ELISA (73),Immunohistochemistry (IHC) (51),Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) (51),Immunofluorescence (IF) (40),Flow Cytometry (FACS) (22),Immunofluorescence (Paraffin-embedded Sections) (IF (p)) (20),Immunocytochemistry (ICC) (18),Immunohistochemistry (Frozen Paraffin-embedded Sections) (IHC (frpe)) (17),Immunoprecipitation (IP) (17),Immunohistochemistry (Frozen Sections) (IHC (fro)) (10),Enzyme Immunoassay (EIA) (8),Dot Blot (DB) (4),Fluorescence Microscopy (FM) (1),Immunoassay (IA) (1),Immunohistochemistry (Formalin-fixed Paraffin-embedded Sections) (1),Proximity Ligation Assay (PLA) (1),RNA Interference (RNAi) (1)
[Pubmed] 1 reference available
規(guī)格 100 μg
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CDK2抗體

產品細節(jié)

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產品細節(jié)

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亞型 IgG
特異性 Human CDK2 / p33
產品特性 Produced in rabbits immunized with purified, recombinant Human CDK2 (rh CDK2, NP_001789.2, Met 1-Leu 298). Total IgG was purified by Protein A affinity chromatography.
純化方法 Affinity Purified
過濾 0.2 μm filtered

目標詳細情況

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目標詳細情況

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別名 CDK2
背景 CDK2 is a member of the Ser/Thr protein kinase family. This protein kinase is highly similar to the gene products of S. cerevisiae cdc28, and S. pombe cdc2. It is a catalytic subunit of the cyclin-dependent protein kinase complex, whose activity is restricted to the G1-S phase, and essential for cell cycle G1/S phase transition. Cdks (cyclin-dependent kinases) are heteromeric serine/threonine kinases that control progression through the cell cycle in concert with their regulatory subunits, the cyclins. Cdks are constitutively expressed and are regulated by several kinases and phosphastases, including Wee1, CDK-activating kinase and Cdc25 phosphatase. Although there are 12 different cdk genes, only 5 have been shown to directly drive the cell cycle (Cdk1, -2, -3, -4, and -6). Following extracellular mitogenic stimuli, cyclin D gene expression is upregulated. Cdk4 forms a complex with cyclin D and phosphorylates Rb protein, leading to liberation of the transcription factor E2F. E2F induces transcription of genes including cyclins A and E, DNA polymerase and thymidine kinase. Cdk4-cyclin E complexes form and initiate G1/S transition. Subsequently, Cdk1-cyclin B complexes form and induce G2/M phase transition. Cdk1-cyclin B activation induces the breakdown of the nuclear envelope and the initiation of mitosis. CDK2 associates with and regulated by the regulatory subunits of the complex including cyclin A or E, CDK inhibitor p21Cip1 (CDKN1A) and p27Kip1 (CDKN1B). Its activity is also regulated by its protein phosphorylation. CDK2 is involved in the control of the cell cycle. It also interacts with cyclins A, B1, B3, D, or E. Activity of CDK2 is maximal during S phase and G2.
NCBI Accession NP_001789.2
研究領域 Cell Cycle, CD Antigens, Surface Receptors of Immune Cells

使用細節(jié)

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使用細節(jié)

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應用備注 ELISA ELISA: 0.5-1.0 μg/mL This antibody can be used at 0.5-1.0 μg/mL with the appropriate secondary reagents to detect Human CDK2. The detection limit for Human CDK2 is 0.039 ng/well.
限制 For Research Use only

貯存及處理

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貯存及處理

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緩沖液 PBS with 5% trehalose
儲存液 Without preservative
注意事項 Preservative-Free. Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.
儲存條件 4 °C/-20 °C/-80 °C
儲存方法 This antibody can be stored at 2 °C-8 °C for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20 °C to -70 °C.
有效期 12 months

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