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MET抗體

抗原
MET
別名 MET, Hgfr, c-Met, HGFR, c-met, C-MET, RG7MT1, hCMT1c, 5730455C01Rik, 5730555F13Rik, 9130215G10Rik, Met
抗原表位
其他選擇 AA 1-932
pTyr1349(43),pTyr1234 (42),pTyr1235 (21),pTyr1003 (16),AA 1-932 (13),AA 1-935 (8),pTyr1356 (7),C-Term (6),Catalytic Domain (5),Tyr1234 (4),AA 1001-1005 (3),AA 1232-1236 (3),AA 1347-1351 (3),Internal Region (3),Ser9 (3),AA 1232-1237 (2),N-Term (2),pTyr1232 (2),pTyr1347 (2),pTyr1350 (2),AA 1231-1240 (1),AA 1361-1379 (1),Ser90 (1),Tyr1003 (1),Tyr1234/Tyr1235 (1),Tyr1235 (1),Tyr1349 (1),phosphorylated (1)
適用
其他選擇 Human
Human(193),Murine (121),Rat ((Rattus)) (112),Dog (Canine) (44),Bovine (36),Guinea Pig (24),Pig (Porcine) (24),Chicken (12),Horse (Equine) (12),Sheep (Ovine) (12),Monkey (1)
宿主
其他選擇 Mouse
Rabbit(192),Mouse (10)
克隆類型 (克隆位點)
單克隆 (1A4G4H7)
標(biāo)記
其他選擇 非結(jié)合性
FITC(7),PE (4),Alexa Fluor 350 (3),Alexa Fluor 488 (3),Alexa Fluor 555 (3),Alexa Fluor 647 (3),Biotin (3),Cy3 (3),Cy5 (3),Cy5.5 (3),Cy7 (3),HRP (3)
zui低檢測濃度 0.078 ng/well
應(yīng)用范圍
其他選擇 ELISA
Western Blotting (WB)(139),ELISA (61),Immunofluorescence (Paraffin-embedded Sections) (IF (p)) (30),Immunohistochemistry (IHC) (24),Immunofluorescence (IF) (15),Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) (13),Flow Cytometry (FACS) (8),Dot Blot (DB) (2),Immunocytochemistry (ICC) (2),Immunoprecipitation (IP) (2)
[Pubmed] 2 references available
規(guī)格 50 μg
發(fā)貨至 中國 (更改)

MET抗體

產(chǎn)品細(xì)節(jié)

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產(chǎn)品細(xì)節(jié)

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克隆位點 1A4G4H7
亞型 IgG1
特異性 Human c-MET / HGFR
交叉反應(yīng) （詳細(xì)） No cross-reactivity with Human cell lysate (293 cell line) in WB and ELISA.
產(chǎn)品特性 This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human c-Met (rh c-Met, NP_000236, Met 1-Thr 932). The IgG fraction of the cell culture supernatant was purified by Protein A affinity chromatography.
過濾 0.2 μm filtered

目標(biāo)詳細(xì)情況

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目標(biāo)詳細(xì)情況

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背景 Hepatocyte growth factor receptor (HGFR), also known as c-Met or mesenchymal-epithelial transition factor (MET), is a receptor tyrosine kinase (RTK) that has been shown to be overexpressed and/or mutated in a variety of malignancies. HGFR protein is produced as a single-chain precursor, and HGF is the only known ligand. Normal HGF/HGFR signaling is essential for embryonic development, tissue repair or wound healing, whereas aberrantly active HGFR has been strongly implicated in tumorigenesis, particularly in the development of invasive and metastatic phenotypes. HGFR protein is a multifaceted regulator of growth, motility, and invasion, and is normally expressed by cells of epithelial origin. Preclinical studies suggest that targeting aberrant HGFR signaling could be an attractive therapy in cancer.
NCBI Accession NP_000236

使用細(xì)節(jié)

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使用細(xì)節(jié)

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應(yīng)用備注 ELISA ELISA: 0.5-1 μg/mL This antibody can be used at 0.5-1 μg/mL with the appropriate secondary reagents to detect Human c-Met. The detection limit for Human c-Met is 0.078 ng/well.
限制 For Research Use only

貯存及處理

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貯存及處理

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緩沖液 PBS with 5% trehalose
儲存液 Without preservative
注意事項 Preservative-Free. Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.
儲存條件 4 °C/-20 °C/-80 °C
儲存方法 This antibody can be stored at 2 °C-8 °C for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20 °C to -70 °C.
有效期 12 months

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