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RUNX1抗體

抗原
Runt-Related Transcription Factor 1 (RUNX1)
別名 RUNX1, runx1, AI462102, AML1, Cbfa2, Pebp2a2, Pebpa2b, AML1-EVI-1, AMLCR1, CBFA2, EVI-1, PEBP2aB, runxa, Runx-1, XAML, Xaml1, aml, aml-1, aml1, aml1-evi-1, amlcr1, cbfa2, evi-1, pebp2ab, Aml1
適用
其他選擇 Human, Murine, Rat ((Rattus)), Dog (Canine), Bovine
Human(224),Murine (111),Rat ((Rattus)) (103),Dog (Canine) (42),Bovine (41),Pig (Porcine) (24),Guinea Pig (12),Xenopus laevis (5),Zebrafish (4),Chicken (3),Rat (Meriones) (2),Zebrafish (Danio rerio) (2),Horse (Equine) (1),Rabbit (1)
宿主
其他選擇 Rabbit
Rabbit(186),Mouse (40),Sheep (3),Goat (2)
克隆類型
多克隆
標記
其他選擇 Cy3
Biotin(6),FITC (6),HRP (5),Alexa Fluor 350 (4),Alexa Fluor 488 (4),Alexa Fluor 555 (4),Alexa Fluor 647 (4),Cy5 (4),Cy5.5 (4),Cy7 (4),Cy3 (3),APC (1),Alkaline Phosphatase (AP) (1),PE (1)
應(yīng)用范圍
其他選擇 Immunofluorescence (Paraffin-embedded Sections) (IF (p))
Western Blotting (WB)(182),ELISA (109),Immunohistochemistry (IHC) (51),Immunofluorescence (Paraffin-embedded Sections) (IF (p)) (39),Immunofluorescence (IF) (37),Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) (36),Immunocytochemistry (ICC) (15),Flow Cytometry (FACS) (11),Enzyme Immunoassay (EIA) (7),Immunohistochemistry (Frozen Paraffin-embedded Sections) (IHC (frpe)) (6),Dot Blot (DB) (2),Immunoprecipitation (IP) (2),Proximity Ligation Assay (PLA) (1)
規(guī)格 100 μL
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RUNX1抗體

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產(chǎn)品細節(jié)

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免疫原 KLH conjugated synthetic peptide derived from human RUNX1
亞型 IgG
特異性 Excitation / Emission Wavelengths: 550nm/570nm
交叉反應(yīng) Rat ((Rattus)), Dog (Canine), Bovine
純化方法 purified by Protein A

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別名 RUNX1
背景 AML1/Runx1 binds DNA as a monomer and through the Runt domain. DNA binding is increased by heterodimerization with CBFB. Isoform AML1L can neither bind DNA nor heterodimerize and interferes with the transactivation activity of AML1/Runx1. CBF binds to the core site, 5'-PYGPYGGT-3', of a number of enhancers and promoters, including murine leukemia virus, polyomavirus enhancer, T cell receptor enhancers, LCK, IL3 and GMCSF promoters. The alpha subunit binds DNA and appears to have a role in the development of normal hematopoiesis. AML1/Runx1 is expressed in a wide variety of tissues and is expressed at the highest levels in thymus, bone marrow and peripheral blood. Defects in AML1/Runx1 are the cause of familial plaet disorder with associated myeloid malignancy, an autosomal dominant disease characterized by qualitative and quantitative plaet defects, and propensity to develop acute myelogenous leukemia.
分子量 49kDa
基因ID 861

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應(yīng)用備注 IF(IHC-P)(1:100-500)
Optimal working dilution should be determined by the investigator.
說明

Excitation / Emission wavelength: 510.550nm / 570.615nm

限制 For Research Use only

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狀態(tài) Liquid
濃度 1 μg/μL
緩沖液 Aqueous buffered solution containing 100 μg/mL BSA, 50 % glycerol and 0.09 % sodium azide.
儲存液 Sodium azide
注意事項 This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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