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PLK1抗體

抗原
Polo-Like Kinase 1 (PLK1)
別名
PLK-1, Plx1, plk, stpk13, 0256/04, 1324/08, CG12306, Dmel\CG12306, PLK1, POLO, POLO/PLK1, Polo, Polo kinase, anon-WO0172774.3, l(3)01673, l(3)77Aa, l(3)S025604, l(3)S132408, PLK, STPK13, Plk, cb525, c ... show more
PLK-1, Plx1, plk, stpk13, 0256/04, 1324/08, CG12306, Dmel\CG12306, PLK1, POLO, POLO/PLK1, Polo, Polo kinase, anon-WO0172774.3, l(3)01673, l(3)77Aa, l(3)S025604, l(3)S132408, PLK, STPK13, Plk, cb525, cb636, ik:tdsubc_2d1, wu:fb37g11, wu:fb76g03, xx:tdsubc_2d1, Snk show less
抗原表位
其他選擇 AA 331-508
pThr210(36),pSer137 (22),C-Term (13),Internal Region (9),AA 1-603 (6),AA 1-604 (6),AA 574-603 (6),AA 100-200 (3),AA 205-214 (3),AA 325-375 (3),AA 331-508 (3),AA 1-50 (2),AA 573-603 (2),N-Term (2),pSer482 (2),pSer486 (2),pSer490 (2),AA 161-440 (1),AA 161-470 (1),AA 176-225 (1),AA 267-603 (1),AA 287-298 (1),AA 300-603 (1),AA 344-360 (1),AA 402-603 (1),Asp204 (1),Ser137 (1),Ser482 (1),Ser486 (1),Ser490 (1),Thr255 (1),Thr256 (1)
適用
其他選擇 Human
Human(185),Murine (81),Rat ((Rattus)) (75),Dog (Canine) (46),Pig (Porcine) (38),Bovine (30),Chicken (14),Xenopus laevis (10),Zebrafish (Danio rerio) (5),Monkey (4),Frog (2),Chimpanzee (1),Fruit Fly (Drosophila melanogaster) (1),Mammalian (1),Non Human Primates (1),Primate (1),Zebrafish (1)
宿主
其他選擇 Mouse
Rabbit(130),Mouse (62),Goat (2)
克隆類型 (克隆位點)
單克隆 (1D1)
標(biāo)記
其他選擇 非結(jié)合性
FITC(5),HRP (5),Biotin (4),Alexa Fluor 350 (3),Alexa Fluor 488 (3),Alexa Fluor 555 (3),Alexa Fluor 647 (3),Cy3 (3),Cy5 (3),Cy5.5 (3),Cy7 (3),APC (2),Alkaline Phosphatase (AP) (2),PE (2)
應(yīng)用范圍
其他選擇 ELISA, Western Blotting (WB), Immunocytochemistry (ICC)
Western Blotting (WB)(152),ELISA (69),Immunohistochemistry (IHC) (49),Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) (43),Immunofluorescence (Paraffin-embedded Sections) (IF (p)) (30),Immunoprecipitation (IP) (30),Immunofluorescence (IF) (27),Immunocytochemistry (ICC) (11),Flow Cytometry (FACS) (9),Immunohistochemistry (Frozen Paraffin-embedded Sections) (IHC (frpe)) (6),Proximity Ligation Assay (PLA) (3),Enzyme Immunoassay (EIA) (2),Immunoassay (IA) (2),Chromatin Immunoprecipitation (ChIP) (1),Fluorescence Microscopy (FM) (1)
[Pubmed] 2 references available
規(guī)格 0.1 mg
發(fā)貨至 中國 (更改)
發(fā)貨時間 24至29個工作日

PLK1抗體

產(chǎn)品細(xì)節(jié)

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產(chǎn)品細(xì)節(jié)

顯示 隱藏
免疫原 Purified recombinant fragment of human PLK1 (AA 331-508) expressed in E. coli.
克隆位點 1D1
亞型 IgG1
純化方法 Purified

目標(biāo)詳細(xì)情況

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目標(biāo)詳細(xì)情況

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別名 PLK1
背景 Synonyms:
PLK, STPK13
PLK1 is critical for the initiation of centrosome maturation. Polo-like kinases (PLKs) are a family of four serine/threonine protein kinases that are critical regulators of cell cycle progression, mitosis, cytokinesis, and the DNA damage response. PLK1, -2 and -3 are ubiquitously expressed, whereas PLK4 is restricted to a few tissues including the testes and the thymus. The mRNA and protein expression of PLK1, -2 and -4 are coordinay regulated during cell cycle progression, but PLK3 levels are independent of the other three family members. Furthermore, PLK3 is a much more stable protein than PLK1, -2 or -4. PLK1 is the most well characterized member of this family and strongly promotes the progression of cells through mitosis. During the various stages of mitosis PLK1 localizes to the centrosomes, kinetochores and central spindle. PLKs are dysregulated in a variety of human cancers. PLK1 overexpression correlates with cellular proliferation and poor prognosis. PLK2 and PLK3 are involved in checkpoint-mediated cell cycle arrest to ensure genetic stability. Loss-of-function mutations in these enzymes can lead to oncogenic transformation.
分子量 68 kDa
基因ID 5347
研究領(lǐng)域 Cancer, Cell Cycle, Kinases/Phosphatases

使用細(xì)節(jié)

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使用細(xì)節(jié)

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應(yīng)用備注 Recommended Dilution:
ELISA: 1/10000, WB: 1/500 - 1/2000, ICC: 1/50
Not yet tested in other applications.
Determining optimal working dilutions by titration test.
限制 For Research Use only

貯存及處理

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貯存及處理

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狀態(tài) Liquid
緩沖液 PBS with 0.05 % sodium azide and 0.5 % protein stabilizer
儲存液 Sodium azide
注意事項 This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
儲存條件 4 °C/-20 °C
儲存方法 Store at 4 °C or at -20 °C for long term.

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