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NDP抗體

抗原
Norrie Disease (Pseudoglioma) (NDP)
別名 EVR2, FEVR, ND, evr2, fevr, xnorrin, Ndph, RGD1563968
抗原表位
其他選擇 N-Term
N-Term(8),AA 1-133 (1),AA 25-133 (1),Middle Region (1)
適用
其他選擇 Human
Human(17),Murine (3),Rat ((Rattus)) (3),Chicken (1),Bovine (1),Dog (Canine) (1),Pig (Porcine) (1),Xenopus laevis (1)
宿主
其他選擇 Rabbit
Rabbit(15),Mouse (2)
克隆類型
多克隆
應(yīng)用范圍
其他選擇 Enzyme Immunoassay (EIA), Immunofluorescence (IF), Western Blotting (WB)
Western Blotting (WB)(17),ELISA (10),Immunocytochemistry (ICC) (8),Immunohistochemistry (IHC) (6),Immunoassay (IA) (1),Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) (1)
[Pubmed] 4 references available
規(guī)格 0.1 mg
發(fā)貨至 中國 (更改)
發(fā)貨時間 29至35個工作日

NDP抗體

產(chǎn)品細節(jié)

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產(chǎn)品細節(jié)

顯示 隱藏
免疫原 Norrin antibody was raised against an 18 amino acid peptide from near the amino terminus of human Norrin.
亞型 IgG
特異性 This antibody detects NDP.
交叉反應(yīng) （詳細） Species reactivity (tested):Human
純化方法 Peptide affinity chromatography

目標(biāo)詳細情況

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目標(biāo)詳細情況

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別名 NDP
背景 Norrie disease is an X-linked genetic disorder characterized by progressive atrophy of the eyes, mental disturbances and deafness. The gene responsible for this disease was initially identified through positional cloning. Norrin, the gene product, encodes a small secreted, cysteine-rich protein that is thought to act as a ligand for the Wnt-receptor/b-catenin signal pathway despite having sequence homology with the Wnt family of proteins. Mice lacking this gene have abnormal blood vessel growth in the vitreous and a disorganized retina, transgenic ectopic expression of Norrin restores normal retinal vasculature. Recent evidence shows that Norrin can attenuate tPA and uPA-mediated death of transformed rat retinal ganglion cells (RGC-5) by activating the Wnt/b-catenin pathway and regulating the phosphorylation of LRP-1, a cell surface receptor for tPA and uPA, suggesting the Norrin may function in vivo by regulating kinases which may alter the phosphorylation of LRP-1.Synonyms: EVR2, Norrie disease protein, Norrin
基因ID 4693
NCBI Accession NP_000257
UniProt Q00604
研究領(lǐng)域 Stem Cells, Wnt, Wnt Signaling

使用細節(jié)

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使用細節(jié)

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應(yīng)用備注 ELISA. Western blot. Immunocytochemistry.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
限制 For Research Use only

貯存及處理

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貯存及處理

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緩沖液 PBS containing 0.02?% sodium azide
儲存液 Sodium azide
注意事項 This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
注意事項 Avoid repeated freezing and thawing.
儲存條件 4 °C/-20 °C

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